Clinical Translation and Implementation of a Bioartificial Pancreas Therapy: A Qualitative Study Exploring the Perspectives of People With Type 1 Diabetes

Autor: Dide de Jongh, MSc, Silke Lapré, BSc, Behiye Özcan, MD, PhD, Robert Zietse, MD, PhD, Eline M. Bunnik, PhD, Emma K. Massey, PhD, the VANGUARD consortium, Ekaterine Berishvili, Laura Mar Fonseca, Fanny Lebreton, Kevin Bellofatto, Juliette Bignard, Jochen Seissler, Leila Wolf-van Buerck, Mohsen Honarpisheh, Yichen Zhang, Yutian Lei, Monika Pehl, Antonia Follenzi, Christina Olgasi, Alessia Cucci, Chiara Borsotti, Simone Assanelli, Lorenzo Piemonti, Antonio Citro, Silvia Pellegrini, Cataldo Pignatelli, Francesco Campo, Olivier Thaunat, Morgane Fouché, Devi Mey, Chiara Parisotto, Giovanna Rossi, Patrick Kugelmeier, Markus Mühlemann, Karolina Pal-Kutas, Marco Cavallaro, Julia Götz, Jeanette Müller

Publikováno v: Transplantation Direct, Vol 10, Iss 10, p e1711 (2024)

Background. The development of a hybrid beta-cell replacement approach, referred to as a personalized, transplantable bioartificial pancreas (BAP), holds promise to treat type 1 diabetes (T1D). This interview study aimed to explore patients’ expect

Externí odkaz: https://doaj.org/article/d25283e0f39a46eabdc19900a2a18f8e

Challenges of COVID-19 Case Forecasting in the US, 2020-2021.

Autor: Velma K Lopez, Estee Y Cramer, Robert Pagano, John M Drake, Eamon B O'Dea, Madeline Adee, Turgay Ayer, Jagpreet Chhatwal, Ozden O Dalgic, Mary A Ladd, Benjamin P Linas, Peter P Mueller, Jade Xiao, Johannes Bracher, Alvaro J Castro Rivadeneira, Aaron Gerding, Tilmann Gneiting, Yuxin Huang, Dasuni Jayawardena, Abdul H Kanji, Khoa Le, Anja Mühlemann, Jarad Niemi, Evan L Ray, Ariane Stark, Yijin Wang, Nutcha Wattanachit, Martha W Zorn, Sen Pei, Jeffrey Shaman, Teresa K Yamana, Samuel R Tarasewicz, Daniel J Wilson, Sid Baccam, Heidi Gurung, Steve Stage, Brad Suchoski, Lei Gao, Zhiling Gu, Myungjin Kim, Xinyi Li, Guannan Wang, Lily Wang, Yueying Wang, Shan Yu, Lauren Gardner, Sonia Jindal, Maximilian Marshall, Kristen Nixon, Juan Dent, Alison L Hill, Joshua Kaminsky, Elizabeth C Lee, Joseph C Lemaitre, Justin Lessler, Claire P Smith, Shaun Truelove, Matt Kinsey, Luke C Mullany, Kaitlin Rainwater-Lovett, Lauren Shin, Katharine Tallaksen, Shelby Wilson, Dean Karlen, Lauren Castro, Geoffrey Fairchild, Isaac Michaud, Dave Osthus, Jiang Bian, Wei Cao, Zhifeng Gao, Juan Lavista Ferres, Chaozhuo Li, Tie-Yan Liu, Xing Xie, Shun Zhang, Shun Zheng, Matteo Chinazzi, Jessica T Davis, Kunpeng Mu, Ana Pastore Y Piontti, Alessandro Vespignani, Xinyue Xiong, Robert Walraven, Jinghui Chen, Quanquan Gu, Lingxiao Wang, Pan Xu, Weitong Zhang, Difan Zou, Graham Casey Gibson, Daniel Sheldon, Ajitesh Srivastava, Aniruddha Adiga, Benjamin Hurt, Gursharn Kaur, Bryan Lewis, Madhav Marathe, Akhil Sai Peddireddy, Przemyslaw Porebski, Srinivasan Venkatramanan, Lijing Wang, Pragati V Prasad, Jo W Walker, Alexander E Webber, Rachel B Slayton, Matthew Biggerstaff, Nicholas G Reich, Michael A Johansson

Publikováno v: PLoS Computational Biology, Vol 20, Iss 5, p e1011200 (2024)

During the COVID-19 pandemic, forecasting COVID-19 trends to support planning and response was a priority for scientists and decision makers alike. In the United States, COVID-19 forecasting was coordinated by a large group of universities, companies

Externí odkaz: https://doaj.org/article/d7c7eeeba3c3436d9f9bb67e5878ebf7

Characterization of intrinsic and effective fitness changes caused by temporarily fixed mutations in the SARS-CoV-2 spike E484 epitope and identification of an epistatic precondition for the evolution of E484A in variant Omicron

Autor: Simon Schröder, Anja Richter, Talitha Veith, Jackson Emanuel, Luca Gudermann, Kirstin Friedmann, Lara M. Jeworowski, Barbara Mühlemann, Terry C. Jones, Marcel A. Müller, Victor M. Corman, Christian Drosten

Publikováno v: Virology Journal, Vol 20, Iss 1, Pp 1-13 (2023)

Abstract Background Intrinsic fitness costs are likely to have guided the selection of lineage-determining mutations during emergence of variants of SARS-CoV-2. Whereas changes in receptor affinity and antibody neutralization have been thoroughly map

Externí odkaz: https://doaj.org/article/faa93fcd2deb4a35b9efcfc3602c8045

Isotonic regression for functionals of elicitation complexity greater than one

Autor: Mühlemann, Anja, Ziegel, Johanna F.

We study the non-parametric isotonic regression problem for bivariate elicitable functionals that are given as an elicitable univariate functional and its Bayes risk. Prominent examples for functionals of this type are (mean, variance) and (Value-at-

Externí odkaz: http://arxiv.org/abs/2106.15369

US National Institutes of Health Prioritization of SARS-CoV-2 Variants

Autor: Sam Turner, Arghavan Alisoltani, Debbie Bratt, Liel Cohen-Lavi, Bethany L. Dearlove, Christian Drosten, Will M. Fischer, Ron A.M. Fouchier, Ana Silvia Gonzalez-Reiche, Lukasz Jaroszewski, Zain Khalil, Eric LeGresley, Marc Johnson, Terry C. Jones, Barbara Mühlemann, David O’Connor, Mayya Sedova, Maulik Shukla, James Theiler, Zachary S. Wallace, Hyejin Yoon, Yun Zhang, Harm van Bakel, Marciela M. Degrace, Elodie Ghedin, Adam Godzik, Tomer Hertz, Bette Korber, Jacob Lemieux, Anna M. Niewiadomska, Diane J. Post, Morgane Rolland, Richard Scheuermann, Derek J. Smith

Publikováno v: Emerging Infectious Diseases, Vol 29, Iss 5, Pp 1-9 (2023)

Since late 2020, SARS-CoV-2 variants have regularly emerged with competitive and phenotypic differences from previously circulating strains, sometimes with the potential to escape from immunity produced by prior exposure and infection. The Early Dete

Externí odkaz: https://doaj.org/article/9c8ff4d1df5c4feb8b350093d5bc9d12