Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Mônica M. Bastos"'
Autor:
Francisco V. C. Mello, Alcione S. Carvalho, Mônica M. Bastos, Nubia Boechat, Claudia A. F. Aiub, Israel Felzenszwalb
Publikováno v:
The Scientific World Journal, Vol 2013 (2013)
Chagas disease is responsible for a large number of human infections and many are also at risk of infection. There is no effective drug for Chagas disease treatment. The Institute of Pharmaceutical Technology at Fiocruz, Brazil, has designed three ni
Externí odkaz:
https://doaj.org/article/fcc8128e7a6b47adbf95a3b4fc1b6894
Publikováno v:
Química Nova, Vol 40, Iss 7, Pp 791-809
The chronic myeloid leukemia (CML) is characterized by presence of the Philadelphia chromosome (Ph), originated from the translocation between chromosomes 9 and 22. This chromosome generates an abnormal protein tyrosine kinase which is responsible fo
Externí odkaz:
https://doaj.org/article/120d3b07229949f9b70c3dc8c0dc2330
Autor:
Fernanda P Z Passos, Jéssica V. Faria, Frederico Silva Castelo-Branco, Mônica M. Bastos, Nubia Boechat, Alice M. R. Bernardino, Silvane M. F. Murta, Maria C.S. Lourenço, Policarpo Ademar Sales Junior, Andressa Paula de Oliveira, Yasmin O D da Cruz, Paulo H A da Costa
Publikováno v:
Medicinal Chemistry. 18:701-709
Background: Tuberculosis (TB) is one of the top ten causes of death worldwide, while Chagas disease (CD) is the parasitic disease that kills the largest number of people in the Americas. TB is the leading cause of death for patients with AIDS; it kil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f49ddccdcab8aa6289c910f66e32772
https://doi.org/10.2174/1573406418666211116144952
https://doi.org/10.2174/1573406418666211116144952
Autor:
Camila R. R. Pão, Thomas Tuschl, Aitor Garzia, Lucas Villas Bôas Hoelz, Felipe Betoni Saraiva, Suelen da Silva Gomes Dias, Dumith Chequer Bou-Habib, Frederico Silva Castelo Branco, Wei Xie, Jingyue Ju, Chuanjuan Tao, Vinicius Cardoso Soares, André C. Ferreira, Stevens K. Rehen, Jairo R. Temerozo, Caroline S. de Freitas, Carine dos Santos da Silva, Carolina Q. Sacramento, Marília Zaluar P. Guimarães, Andrew Owen, Thiago Moreno L. Souza, Patrícia T. Bozza, Xuanting Wang, Nubia Boechat, Mayara Mattos, Rajith K. R. Rajoli, Dinshaw J. Patel, Steffen Jockusch, Marcelo Alves Ferreira, Fernando A. Bozza, Natalia Fintelman-Rodrigues, Gabriela Vitória, Livia Goto-Silva, Tácio Vinício Amorim Fernandes, Aline de Paula Dias Da Silva, Mônica M. Bastos, Carolina da S. G. Pedrosa, Leticia R. Q. Souza, James J. Russo, Minchen Chien
Publikováno v:
Journal of Antimicrobial Chemotherapy
Background Current approaches of drug repurposing against COVID-19 have not proven overwhelmingly successful and the SARS-CoV-2 pandemic continues to cause major global mortality. SARS-CoV-2 nsp12, its RNA polymerase, shares homology in the nucleotid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba3878b9eb5f2dd7bdc20ace00f834b
https://doi.org/10.1093/jac/dkab072
https://doi.org/10.1093/jac/dkab072
Autor:
Debora Inacio Leite Firmino Marinho, Anna C. Cunha, Henayle Fernandes Canzian, Lucas Villas Bôas Hoelz, Mônica M. Bastos, Nubia Boechat, Luiz Claudio Ferreira Pimentel
Publikováno v:
Current Topics in Medicinal Chemistry. 20:227-243
The phenylamino-pyrimidine (PAP) nucleus has been demonstrated to be useful for the development of new drugs and is present in a wide variety of antiretroviral agents and tyrosine kinase inhibitors (TKIs). This review aims to evaluate the application
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98542fb8d5db2e7884ed0d69ecb0e7b7
https://doi.org/10.2174/1568026620666200124094949
https://doi.org/10.2174/1568026620666200124094949
Autor:
Lucas Villas Bôas Hoelz, Anna C. Cunha, Frederico Silva Castelo Branco, Mônica M. Bastos, Henayle Fernandes Canzian, Nubia Boechat, Andressa Paula de Oliveira, Jackson A. L. C. Resende, Luiz Claudio Ferreira Pimentel, Vinícius R. Campos, Rafael Ferreira Dantas, Floriano Paes Silva Junior
Publikováno v:
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 2260-2269 (2021)
Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 2260-2269 (2021)
The enzyme tyrosine kinase BCR-Abl-1 is the main molecular target in the treatment of chronic myeloid leukemia and can be competitively inhibited by tyrosine kinase inhibitors such as imatinib. New potential competitive inhibitors were synthesized us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676ba28896d90ba5557acef9e2060dee
https://pubmed.ncbi.nlm.nih.gov/34621389
https://pubmed.ncbi.nlm.nih.gov/34621389
Autor:
Elaine Cruz Rosas, Maria de Lourdes G. Ferreira, Nubia Boechat, Paula M. Sa, Leonardo N. Seito, Rita de C. C. Carvalho, Julia Penna Coutinho, Antoniana U. Krettli, Mônica M. Bastos, Luiz C. S. Pinheiro
Publikováno v:
Bioorganicmedicinal chemistry. 28(24)
Malaria is a disease that requires new drugs not only to fight Plasmodium but also to reduce symptoms of infection such as fever and inflammation. A series of 21 hybrid compounds were designed from chloroquine (CQ) and primaquine (PQ) linked to the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0de9d7803fab45f78e39bbd4c56e35
https://pubmed.ncbi.nlm.nih.gov/33166927
https://pubmed.ncbi.nlm.nih.gov/33166927
Autor:
José Daniel Figueroa Villar, Lucas Villas Bôas Hoelz, Maria de Nazaré Correia Soeiro, Aline Nefertiti Silva da Gama, Fábio de Vasconcellos Fontes, D. G. J. Batista, Patrícia Bernardino da Silva, Cristiane França da Silva, Nubia Boechat, Débora Inácio Leite, Maria da Conceição Avelino Dias Bianco, Mônica M. Bastos, Raiza Brandão Peres, Andressa Paula de Oliveira
Publikováno v:
Chemical Biology & Drug Design. 92:1670-1682
Chagas disease has spread throughout the world mainly because of the migration of infected individuals. In Brazil, only benznidazole (Bnz) is used; however, it is toxic and not active in the chronic phase, and cases of resistance are described. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3978d0a0855a1a8b655b3c7c50cdc842
https://doi.org/10.1111/cbdd.13333
https://doi.org/10.1111/cbdd.13333
Autor:
Debora Inacio Leite Firmino Marinho, Mônica M. Bastos, Nubia Boechat, Maria da Conceição Avelino Dias Bianco, Lucas Villas Bôas Hoelz
Publikováno v:
Pharmaceuticals, Vol 14, Iss 893, p 893 (2021)
Pharmaceuticals
Pharmaceuticals
Acquired immunodeficiency syndrome (AIDS) is caused by human immunodeficiency virus (HIV) and remains a global health problem four decades after the report of its first case. Despite success in viral load suppression and the increase in patient survi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf87c16a253c6e12680e54623e72b64
https://doi.org/10.3390/ph14090893
https://doi.org/10.3390/ph14090893
Autor:
Lucas Villas Bôas Hoelz, Nubia Boechat, Larissa C. Gomes, Flavia da Cunha Vasconcelos, Liviane D. de Azevedo, Mônica M. Bastos, Andressa Paula de Oliveira, Ana C. M. de Almeida, Rafael Ferreira Dantas, Floriano Paes Silva Junior, Raquel Ciuvalschi Maia
Publikováno v:
Medicinal Chemistry Research. 26:2929-2941
Imatinib was the first representative of the class of Breakpoint cluster region-Abelson murine leukemia viral oncogene homolog (BCR-ABL) tyrosine kinase inhibitors used for the treatment of chronic myeloid leukemia. Second-generation and third-genera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ebf34b17a4948dbf7e36c82594da46c
https://doi.org/10.1007/s00044-017-1993-8
https://doi.org/10.1007/s00044-017-1993-8