Discovery of novel thiosemicarbazone-acridine targeting butyrylcholinesterase with antioxidant, metal complexing and neuroprotector abilities as potential treatment of Alzheimer's disease: In vitro, in vivo, and in silico studies.

Autor: Silva Sousa GL; Institute of Chemistry, Universidade Federal Rural do Rio de Janeiro, Seropédica, 23897-000, Brazil., Nadur NF; Institute of Chemistry, Universidade Federal Rural do Rio de Janeiro, Seropédica, 23897-000, Brazil., de Almeida Peixoto Ferreira L; Institute of Chemistry, Universidade Federal Rural do Rio de Janeiro, Seropédica, 23897-000, Brazil., da Silva Honório T; Cell Culture Laboratory (LabCel), Department of Drugs and Pharmaceutics, Faculty of Pharmacy, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil., Simon A; Cell Culture Laboratory (LabCel), Department of Drugs and Pharmaceutics, Faculty of Pharmacy, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil., Cabral LM; Cell Culture Laboratory (LabCel), Department of Drugs and Pharmaceutics, Faculty of Pharmacy, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil., Móra Santos ML; Institute of Biomedical Sciences, Universidade Federal do Rio de Janeiro, 21941-902, Brazil., Andrade B; Institute of Biomedical Sciences, Universidade Federal do Rio de Janeiro, 21941-902, Brazil., de Lima EV; Institute of Biomedical Sciences, Universidade Federal do Rio de Janeiro, 21941-902, Brazil., Clarke JR; Institute of Biomedical Sciences, Universidade Federal do Rio de Janeiro, 21941-902, Brazil., Castro RN; Institute of Chemistry, Universidade Federal Rural do Rio de Janeiro, Seropédica, 23897-000, Brazil., Olímpio de Moura R; Department of Chemistry, Universidade Estadual da Paraíba, Campina Grande, 58429-500, Brazil., Kümmerle AE; Institute of Chemistry, Universidade Federal Rural do Rio de Janeiro, Seropédica, 23897-000, Brazil. Electronic address: akummerle@ufrrj.br.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2024 Nov 07; Vol. 281, pp. 117030. Date of Electronic Publication: 2024 Nov 07.