The Mithralog EC-7072 Induces Chronic Lymphocytic Leukemia Cell Death by Targeting Tonic B-Cell Receptor Signaling

Autor: Seila Lorenzo-Herrero, Christian Sordo-Bahamonde, Gabriel Bretones, Ángel R. Payer, Ana P. González-Rodríguez, Esther González-García, Jhudit Pérez-Escuredo, Mónica Villa-Álvarez, Luz-Elena Núñez, Francisco Morís, Segundo Gonzalez, Alejandro López-Soto

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

B-cell receptor (BCR)-dependent signaling is central for leukemia B-cell homeostasis, as underscored by the promising clinical results obtained in patients with chronic lymphocytic leukemia (CLL) treated with novel agents targeting components of this

Externí odkaz: https://doaj.org/article/c9308b239ec243ad9b6907c1bcabb68e

Ig-like transcript 2 (ILT2) suppresses T cell function in chronic lymphocytic leukemia

Autor: Mónica Villa-Álvarez, Seila Lorenzo-Herrero, Ana P. Gonzalez-Rodriguez, Alejandro López-Soto, Angel R. Payer, Esther Gonzalez-Garcia, Leticia Huergo-Zapico, Segundo Gonzalez

Publikováno v: OncoImmunology, Vol 6, Iss 10 (2017)

Chronic lymphocytic leukemia (CLL) is associated with a profound dysregulation of the immune system. Loss of T cell function is frequently caused in cancer by sustained signaling of inhibitory receptors. Here, we analyzed the role of the novel inhibi

Externí odkaz: https://doaj.org/article/523b813c33e24422bcd9885b4fbdffcf

NK Cells in the Treatment of Hematological Malignancies

Autor: Segundo Gonzalez, Ana P Gonzalez-Rodriguez, Mónica Villa-Álvarez, Christian Sordo-Bahamonde, Seila Lorenzo-Herrero

Publikováno v: Journal of Clinical Medicine, Vol 8, Iss 10, p 1557 (2019)
WOS:000498398500055
RUO. Repositorio Institucional de la Universidad de Oviedo
Scipedia SL
Journal of Clinical Medicine

Natural killer (NK) cells have the innate ability to kill cancer cells, however, tumor cells may acquire the capability of evading the immune response, thereby leading to malignancies. Restoring or potentiation of this natural antitumor activity of N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2972127d82bc4de80bc4e9c53bd4b6e
https://www.mdpi.com/2077-0383/8/10/1557

NKG2D signaling in cancer immunosurveillance

Autor: Segundo Gonzalez, Mónica Villa-Álvarez, Leticia Huergo-Zapico, Andrea Acebes-Huerta, Alejandro López-Soto

Publikováno v: International Journal of Cancer. 136:1741-1750

The immune system is able to detect and eliminate transformed cells. The activating receptor NKG2D is particularly relevant for cancer immunosurveillance. NKG2D ligand expression renders tumor cells more susceptible to be killed by NK and T cells, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b05c6284b7d52fd88487a6e6b509a155
https://doi.org/10.1002/ijc.28775

Expansion of NK Cells and Reduction of NKG2D Expression in Chronic Lymphocytic Leukemia. Correlation with Progressive Disease

Autor: Esther González-García, Segundo Gonzalez, Angel Ramirez Payer, Andrea Acebes-Huerta, Azahara Fernández-Guizán, Ana P Gonzalez-Rodriguez, Juan Contesti, Alejandro López-Soto, Leticia Huergo-Zapico, Mónica Villa-Álvarez

Publikováno v: PLoS ONE
Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
PLoS ONE, Vol 9, Iss 10, p e108326 (2014)

The immune system may mediate anti-tumor responses in chronic lymphocytic leukemia (CLL) which may affect disease progression and survival. In this study, we analyzed the immune characteristics of 99 consecutive previously diagnosed CLL patients and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41782390ff688106beee0e0cd2886f69
https://doi.org/10.1371/journal.pone.0108326