Extrastriatal monoaminergic dysfunction and enhanced microglial activation in idiopathic rapid eye movement sleep behaviour disorder

Autor: Morten Gersel Stokholm, Alex Iranzo, Karen Østergaard, Mónica Serradell, Marit Otto, Kristina Bacher Svendsen, Alicia Garrido, Dolores Vilas, Peter Parbo, Per Borghammer, Joan Santamaria, Arne Møller, Carles Gaig, David J. Brooks, Eduardo Tolosa, Nicola Pavese

Publikováno v: Neurobiology of Disease, Vol 115, Iss , Pp 9-16 (2018)

Background: The majority of patients diagnosed with idiopathic rapid eye movement sleep behaviour disorder (iRBD) progress over time to a Lewy-type α-synucleinopathy such as Parkinson's disease or dementia with Lewy bodies. This in vivo molecular im

Externí odkaz: https://doaj.org/article/fe8be94c085543cf8701d69a6a62cecd

Former participation in professional football as an occupation in patients with isolated REM sleep behavior disorder leading to a synucleinopathy: a case–control study

Autor: Alejandra Collía, Alex Iranzo, Mónica Serradell, Amaia Muñoz-Lopetegi, Gerard Mayà, Joan Santamaría, Raquel Sánchez-Valle, Carles Gaig

Publikováno v: Journal of Neurology. 270:3234-3242

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02ab6804cce7720f414a5b53fee3bfde
https://doi.org/10.1007/s00415-023-11591-8

Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study

Autor: Ellen Gelpi, Alison Green, Mónica Serradell, Eduard Tolosa, Renata L. Riha, Raquel Sánchez-Valle, Joan Santamaria, Anutra Chumbala Na Ayudhaya, Alex Iranzo, Graham Fairfoul, Isabel Vilaseca, Carles Gaig

Publikováno v: Iranzo, A, Fairfoul, G, Ayudhaya, A C N, Serradell, M, Gelpi, E, Vilaseca, I, Sanchez-valle, R, Gaig, C, Santamaria, J, Tolosa, E, Riha, R L & Green, A J E 2021, ' Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study ', The Lancet Neurology, vol. 20, no. 3, pp. 203-212 . https://doi.org/10.1016/S1474-4422(20)30449-X

Summary Background Isolated rapid-eye-movement (REM) sleep behaviour disorder (IRBD) can be part of the prodromal stage of the α-synucleinopathies Parkinson's disease and dementia with Lewy bodies. Real-time quaking-induced conversion (RT-QuIC) anal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec5d1407d902d94b19bacba1e54fe57
https://doi.org/10.1016/s1474-4422(20)30449-x

Imaging dopamine function and microglia in asymptomatic LRRK2 mutation carriers

Autor: Per Borghammer, Karen Østergaard, Peter Parbo, Arne Møller, Kristian Stær, David J. Brooks, Nicola Pavese, Alicia Garrido, Eduardo Tolosa, Morten Gersel Stokholm, Mónica Serradell, María José Martí, Alex Iranzo

Publikováno v: Stokholm, M G, Garrido, A, Tolosa, E, Serradell, M, Iranzo, A, Ostergaard, K, Borghammer, P, Moller, A, Parbo, P, Staer, K, Brooks, D J, Jose Marti, M & Pavese, N 2020, ' Imaging dopamine function and microglia in asymptomatic LRRK2 mutation carriers ', Journal of Neurology, vol. 267, no. 8, pp. 2296-2300 . https://doi.org/10.1007/s00415-020-09830-3
Journal of Neurology

Neuroinflammation (microglial activation) and subclinical nigrostriatal dysfunction have been reported in subjects at risk of Parkinsonism. Eight non-manifesting carriers (NMCs) of LRRK2 G2019S mutation had 11C-PK11195 and 18F-DOPA PET to assess micr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d9ae05a56f269dd603e6775f67cce3
https://doi.org/10.1007/s00415-020-09830-3

Monocyte markers correlate with immune and neuronal brain changes in REM sleep behavior disorder

Autor: Karen Østergaard, Carles Gaig, David J. Brooks, Kristine Farmen, Eduardo Tolosa, Mónica Serradell, Per Borghammer, Kristina Bacher Svendsen, Alicia Garrido, Morten Gersel Stokholm, Marit Otto, Alex Iranzo, Sara K. Nissen, Arne Møller, Nicola Pavese, Joan Santamaria, Dolores Vilas, Marina Romero-Ramos

Publikováno v: Farmen, K, Nissen, S K, Stokholm, M G, Iranzo, A, Østergaard, K, Serradell, M, Otto, M, Svendsen, K B, Garrido, A, Vilas, D, Borghammer, P, Santamaria, J, Møller, A, Gaig, C, Brooks, D J, Tolosa, E, Pavese, N & Romero-Ramos, M 2021, ' Monocyte markers correlate with immune and neuronal brain changes in REM sleep behavior disorder ', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 10, e2020858118 . https://doi.org/10.1073/pnas.2020858118
Proc Natl Acad Sci U S A

Synucleinopathies are neurodegenerative diseases with both central and peripheral immune responses. However, whether the peripheral immune changes occur early in disease and their relation to brain events is yet unclear. Isolated rapid-eye-movement (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2becded01064f4f976e0f987f5c183a5
https://doi.org/10.1073/pnas.2020858118