CDK contribution to DSB formation and recombination in fission yeast meiosis.

Autor: Luisa F Bustamante-Jaramillo, Celia Ramos, Leticia Alonso, Aroa Sesmero, Mónica Segurado, Cristina Martín-Castellanos

Publikováno v: PLoS Genetics, Vol 15, Iss 1, p e1007876 (2019)

CDKs (cyclin-dependent kinases) associate with different cyclins to form different CDK-complexes that are fundamental for an ordered cell cycle progression, and the coordination of this progression with different aspects of the cellular physiology. D

Externí odkaz: https://doaj.org/article/fde918d50a224268af4b5a5007af880a

Exo1 phosphorylation inhibits exonuclease activity and prevents fork collapse in rad53 mutants independently of the 14-3-3 proteins

Autor: María Fernández, Cristina Martín-Castellanos, Esther C. Morafraile, Raquel Carreira, Miguel G. Blanco, Mónica Segurado, Alberto Bugallo

Publikováno v: Minerva: Repositorio Institucional de la Universidad de Santiago de Compostela
Universidad de Santiago de Compostela (USC)
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
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Nucleic Acids Research
Digital.CSIC. Repositorio Institucional del CSIC

The S phase checkpoint is crucial to maintain genome stability under conditions that threaten DNA replication. One of its critical functions is to prevent Exo1-dependent fork degradation, and Exo1 is phosphorylated in response to different genotoxic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021f8e7a87b12b1ef05522c9875f4675
http://hdl.handle.net/10347/24486

Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks

Autor: John F.X. Diffley, Mónica Segurado

Publikováno v: Genes & Development. 22:1816-1827

The DNA damage checkpoint plays a crucial role in maintaining functional DNA replication forks when cells are exposed to genotoxic agents. In budding yeast, the protein kinases Mec1 (ATR) and Rad53 (Chk2) are especially important in this process. How

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633de16f3a8e16b28f23f5845256092c
https://doi.org/10.1101/gad.477208

Different nucleosomal architectures at early and late replicating origins in Saccharomyces cerevisiae

Autor: Esther C. Morafraile, Mónica Segurado, Ignacio Soriano, Enrique Vázquez, Francisco Antequera

Publikováno v: BMC Genomics
Digital.CSIC. Repositorio Institucional del CSIC
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License.
[Background]: Eukaryotic genomes are replicated during S phase according to a temporal program. Several determinants control the timing of or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345882fe69aea15f3ca7c86fb9b860b2
http://hdl.handle.net/10261/103027

Structural diversity and dynamics of genomic replication origins in Schizosaccharomyces pombe

Autor: Mónica Segurado, Francisco Antequera, Cristina Cotobal

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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El pdf del artículo es la versión pre-print.
DNA replication origins (ORI) in Schizosaccharomyces pombe colocalize with adenine and thymine (A+T)-rich regions, and earlier analyses have established a size from 0.5 to over 3 kb for a DNA fragme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3996011423c2e4bf89950c8b3b5cde3
http://hdl.handle.net/10261/49619