Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Mónica Söllhuber"'
Autor:
María Carmen Bravo-Llatas, Juan Domingo Sánchez Cebrián, Marta Hortelano Morales, Marcello Capacchione, Andrés Rafael Alcántara León, Carmen del Campo Pérez, Olmo Martín Cámara, María Fernández Fernández, Loreto Salazar Martínez de Pisón, Pilar Cledera Crespo, Pilar López-Alvarado Gutiérrez, Giorgio Giorgi, Carmen Freire, Mónica Söllhuber Kretzer
Publikováno v:
INTED Proceedings.
Publikováno v:
Tetrahedron: Asymmetry. 12:3019-3028
The 1-methyl(iso-propyl)-2-benzyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-diones 8 and 9 could be regio- and diastereoselectively alkylated at C(4) with retention of configuration at both stereocentres.
Publikováno v:
Synlett. 2001:1387-1390
Publikováno v:
Tetrahedron: Asymmetry. 9:4275-4284
The substitution of the 4-methyl group by a 4-isopropyl group in the 2-benzyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-dione system allows a notable improvement in the stereoselective alkylation at C-1. The configuration of the newly introduced
Publikováno v:
Tetrahedron: Asymmetry. 9:483-501
Alkyl halides behave differently to benzyl halides in C-1 alkylation of the title compounds. The syn and anti 1,4-disubstituted diastereomers thus obtained show different regioselectivity by further alkylation leading to the 1,4,4- and 1,1,4-trisubst
Publikováno v:
Tetrahedron: Asymmetry. 9:249-258
Acylation of 1 leads to the syn derivatives 2 . Traces of the anti isomers equilibrate to the syn isomers when stored in CHCl 3 . Aldol condensation showed great diastereoselectivity, but racemization could not be avoided. The configuration of the ne
Autor:
Félix L. Buenadicha, Carmen Avendaño, Modesta Espada, Sonsoles Martín-Santamaría, Mónica Söllhuber
Publikováno v:
The Journal of Organic Chemistry. 62:6424-6428
Publikováno v:
Tetrahedron. 53:3231-3242
Michael addition of lithiated 2,5-dimethoxypivaloylaniline to diisopropyl arylidenmalonates, followed by acid cyclization, affords 5,8-dimethoxy-4-aryl-3,4-dihydro-2(1 H )quinolinones ( 5 ). These compounds are very inert to the 3,4-dehydrogenation,
Publikováno v:
Liebigs Annalen. 1995:1895-1899
The title compounds 12, which are key intermediates for antitumoral diazaquinomycin A analogues, are obtained by intramolecular Wittig reaction of 1‐[3′,6′‐dimethoxy‐2′‐(α‐oxoacylamino)phenyl]alkyltriphenylphosphonium salts 11, which
Publikováno v:
Journal of Heterocyclic Chemistry. 29:1541-1544
The synthesis of 6β‐hydroxy‐ and 6β,7β‐dihydroxy‐8‐alkyl‐8‐azabicyclo[3.2.1]octane‐3‐spiro‐5′‐hydantoins was stereoselectively achieved by Bucherer‐Bergs reaction of the corresponding ketones. An α configuration on C3 wa