Výsledky vyhledávání - "Mónica Pascual-García"

Akademický článek

LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

LIF is a pleiotropic cytokine that promotes an immunosuppressive microenvironment and has critical functions in embryonic development. Here, the authors show that LIF regulates CD8+ T cell tumor infiltration in cancer by repressing CXCL19 and promoti

Externí odkaz: https://doaj.org/article/eafd754e38d148f4af2177cb43fd4fa5

Zobrazit plný text záznamu

Akademický článek

The Nuclear Receptor LXR Limits Bacterial Infection of Host Macrophages through a Mechanism that Impacts Cellular NAD Metabolism

Publikováno v: Cell Reports, Vol 18, Iss 5, Pp 1241-1255 (2017)

Macrophages exert potent effector functions against invading microorganisms but constitute, paradoxically, a preferential niche for many bacterial strains to replicate. Using a model of infection by Salmonella Typhimurium, we have identified a molecu

Externí odkaz: https://doaj.org/article/439542872a5e4778b31f8b15c628ff56

Zobrazit plný text záznamu

Repression of endogenous retroviruses prevents antiviral immune response and is required for mammary gland development

Autor: Alexandra Van Keymeulen, Andrés Castellanos, Salvador Aznar Benitah, Mónica Pascual-García, Carmelo Laudanna, Juan M. Vaquerizas, Uxue Urdiroz-Urricelqui, Domenica Marchese, Magdolna Djurec, Quirze Rovira, Neus Prats, Holger Heyn, Alexandra Avgustinova

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona

The role of heterochromatin in cell fate specification during development is unclear. We demonstrate that loss of the lysine 9 of histone H3 (H3K9) methyltransferase G9a in the mammary epithelium results in de novo chromatin opening, aberrant formati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73f3f397ee7b67cf4721704b117dfc9
http://hdl.handle.net/2445/178649

Zobrazit plný text záznamu

LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy

Publikováno v: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Scientia
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Nature Communications
Recercat. Dipósit de la Recerca de Catalunya
instname
Repisalud
Instituto de Salud Carlos III (ISCIII)

Cancer response to immunotherapy depends on the infiltration of CD8+ T cells and the presence of tumor-associated macrophages within tumors. Still, little is known about the determinants of these factors. We show that LIF assumes a crucial role in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3562526c931f1c9279325cea163e8e9b
https://hdl.handle.net/20.500.12105/8322

Zobrazit plný text záznamu

CD8 down-regulation on cytotoxic T lymphocytes of patients with endometrioid endometrial carcinomas

Autor: Jaime Prat, Neus Serrat, Mónica Pascual-García, Silvia Vidal, Juan C. Nieto, Emanuela D'Angelo, Inigo Espinosa, Ramón Rovira, Raquel Muñoz, Cristina Bértolo

Publikováno v: HUMAN PATHOLOGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

Carcinogenesis is a multistep process in which cancer cells and tumor stroma cells play important roles. T lymphocytes are immune constituents of tumor stoma and play a crucial function in anti-tumor response. By immunohistochemistry and flow cytomet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e272464b9bf96f60cc3b43d3259630c
https://doi.org/10.1016/j.humpath.2016.05.025

Zobrazit plný text záznamu

Migrated T lymphocytes into malignant pleural effusions: an indicator of good prognosis in lung adenocarcinoma patients

Autor: Ana M. Muñoz-Fernandez, Mónica Pascual-García, Virginia Pajares, Silvia Bielsa, Nuria Calvo, Carlos Zamora, Inigo Espinosa, Silvia Vidal, Juan C. Nieto, Maria Mulet, José M. Porcel

Publikováno v: Scientific Reports
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Repositorio Abierto de la UdL
Universitad de Lleida
Recercat. Dipósit de la Recerca de Catalunya
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)

The presence of leukocyte subpopulations in malignant pleural effusions (MPEs) can have a different impact on tumor cell proliferation and vascular leakiness, their analysis can help to understand the metastatic microenvironment. We analyzed the rela

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b579b2eef4f26941e07987f4995736
https://pubmed.ncbi.nlm.nih.gov/30816121

Zobrazit plný text záznamu

Biological Roles of Liver X Receptors in Immune Cells

Autor: Mónica Pascual-García, Annabel F. Valledor

Publikováno v: Archivum Immunologiae et Therapiae Experimentalis. 60:235-249

Liver X receptors (LXRs) are members of the nuclear receptor superfamily that are activated by specific oxysterols. LXRs heterodimerize with retinoid X receptors to regulate positively the expression of a variety of target genes, many of which are in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd6b4484ab95dd4cb18b6d64687dbe6
https://doi.org/10.1007/s00005-012-0179-9

Zobrazit plný text záznamu

Liver X Receptors Inhibit Macrophage Proliferation through Downregulation of Cyclins D1 and B1 and Cyclin-Dependent Kinases 2 and 4

Autor: Annabel F. Valledor, Theo J.C. Van Berkel, Theresa E. Leon, Francisco Lozano, Maria-Rosa Sarrias, José M. Carbó, Ruud Out, Jonathan Matalonga, Antonio Celada, Mónica Pascual-García

Publikováno v: The Journal of Immunology. 186:4656-4667

Macrophages serve essential functions as regulators of immunity and homeostasis, and their proliferation contributes to pathogenesis of certain disorders. In this report, we show that induction of macrophage proliferation by the growth factor M-CSF i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8423a1bbf2f0bcea3cfe811d71e59be
https://doi.org/10.4049/jimmunol.1000585

Zobrazit plný text záznamu

Reciprocal negative cross-talk between liver X receptors (LXRs) and STAT1: effects on IFN-γ-induced inflammatory responses and LXR-dependent gene expression

Autor: Jonathan Matalonga, José M. Carbó, Joan Carles Escolà-Gil, Mónica Pascual-García, Annabel F. Valledor, Josep Julve, Knut R. Steffensen, Esther Pérez-Navarro, Laura Rué, Herbert Auer, Antonio Celada, Theresa E. Leon

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 190(12)

Liver X receptors (LXRs) exert key functions in lipid homeostasis and in control of inflammation. In this study we have explored the impact of LXR activation on the macrophage response to the endogenous inflammatory cytokine IFN-γ. Transcriptional p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622c3e938abd10e653e923acfb0482f9
https://pubmed.ncbi.nlm.nih.gov/23686490

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání