Adaptive Mistranslation Accelerates the Evolution of Fluconazole Resistance and Induces Major Genomic and Gene Expression Alterations in Candida albicans

Autor: Tobias Weil, Rodrigo Santamaría, Wanseon Lee, Johan Rung, Noemi Tocci, Darren Abbey, Ana R. Bezerra, Laura Carreto, Gabriela R. Moura, Mónica Bayés, Ivo G. Gut, Attila Csikasz-Nagy, Duccio Cavalieri, Judith Berman, Manuel A. S. Santos

Publikováno v: mSphere, Vol 2, Iss 4 (2017)

ABSTRACT Regulated erroneous protein translation (adaptive mistranslation) increases proteome diversity and produces advantageous phenotypic variability in the human pathogen Candida albicans. It also increases fitness in the presence of fluconazole,

Externí odkaz: https://doaj.org/article/27634fd55d184dabb3cf213225caa91a

Colorectal adenomas contain multiple somatic mutations that do not coincide with synchronous adenocarcinoma specimens.

Autor: José P Vaqué, Nerea Martínez, Ignacio Varela, Fidel Fernández, Marta Mayorga, Sophia Derdak, Sergi Beltrán, Thaidy Moreno, Carmen Almaraz, Gonzalo De Las Heras, Mónica Bayés, Ivo Gut, Javier Crespo, Miguel A Piris

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0119946 (2015)

We have performed a comparative ultrasequencing study of multiple colorectal lesions obtained simultaneously from four patients. Our data show that benign lesions (adenomatous or hyperplastic polyps) contain a high mutational load. Additionally multi

Externí odkaz: https://doaj.org/article/52d4f8cd1a1141338de6770213a8d573

International network of cancer genome projects

Autor: Thomas J, Hudson, Warwick, Anderson, Axel, Artez, Anna D, Barker, Cindy, Bell, Rosa R, Bernabé, M K, Bhan, Fabien, Calvo, Iiro, Eerola, Daniela S, Gerhard, Alan, Guttmacher, Mark, Guyer, Fiona M, Hemsley, Jennifer L, Jennings, David, Kerr, Peter, Klatt, Patrik, Kolar, Jun, Kusada, David P, Lane, Frank, Laplace, Lu, Youyong, Gerd, Nettekoven, Brad, Ozenberger, Jane, Peterson, T S, Rao, Jacques, Remacle, Alan J, Schafer, Tatsuhiro, Shibata, Michael R, Stratton, Joseph G, Vockley, Koichi, Watanabe, Huanming, Yang, Matthew M F, Yuen, Bartha M, Knoppers, Martin, Bobrow, Anne, Cambon-Thomsen, Lynn G, Dressler, Stephanie O M, Dyke, Yann, Joly, Kazuto, Kato, Karen L, Kennedy, Pilar, Nicolás, Michael J, Parker, Emmanuelle, Rial-Sebbag, Carlos M, Romeo-Casabona, Kenna M, Shaw, Susan, Wallace, Georgia L, Wiesner, Nikolajs, Zeps, Peter, Lichter, Andrew V, Biankin, Christian, Chabannon, Lynda, Chin, Bruno, Clément, Enrique, de Alava, Françoise, Degos, Martin L, Ferguson, Peter, Geary, D Neil, Hayes, Amber L, Johns, Arek, Kasprzyk, Hidewaki, Nakagawa, Robert, Penny, Miguel A, Piris, Rajiv, Sarin, Aldo, Scarpa, Marc, van de Vijver, P Andrew, Futreal, Hiroyuki, Aburatani, Mónica, Bayés, David D L, Botwell, Peter J, Campbell, Xavier, Estivill, Sean M, Grimmond, Ivo, Gut, Martin, Hirst, Carlos, López-Otín, Partha, Majumder, Marco, Marra, John D, McPherson, Zemin, Ning, Xose S, Puente, Yijun, Ruan, Hendrik G, Stunnenberg, Harold, Swerdlow, Victor E, Velculescu, Richard K, Wilson, Hong H, Xue, Liu, Yang, Paul T, Spellman, Gary D, Bader, Paul C, Boutros, Paul, Flicek, Gad, Getz, Roderic, Guigó, Guangwu, Guo, David, Haussler, Simon, Heath, Tim J, Hubbard, Tao, Jiang, Steven M, Jones, Qibin, Li, Nuria, López-Bigas, Ruibang, Luo, Lakshmi, Muthuswamy, B F Francis, Ouellette, John V, Pearson, Victor, Quesada, Benjamin J, Raphael, Chris, Sander, Terence P, Speed, Lincoln D, Stein, Joshua M, Stuart, Jon W, Teague, Yasushi, Totoki, Tatsuhiko, Tsunoda, Alfonso, Valencia, David A, Wheeler, Honglong, Wu, Shancen, Zhao, Guangyu, Zhou, Mark, Lathrop, Gilles, Thomas, Teruhiko, Yoshida, Myles, Axton, Chris, Gunter, Linda J, Miller, Junjun, Zhang, Syed A, Haider, Jianxin, Wang, Christina K, Yung, Anthony, Cros, Anthony, Cross, Yong, Liang, Saravanamuttu, Gnaneshan, Jonathan, Guberman, Jack, Hsu, Don R C, Chalmers, Karl W, Hasel, Terry S H, Kaan, William W, Lowrance, Tohru, Masui, Laura Lyman, Rodriguez, Catherine, Vergely, David D L, Bowtell, Nicole, Cloonan, Anna, deFazio, James R, Eshleman, Dariush, Etemadmoghadam, Brooke B, Gardiner, Brooke A, Gardiner, James G, Kench, Robert L, Sutherland, Margaret A, Tempero, Nicola J, Waddell, Peter J, Wilson, Steve, Gallinger, Ming-Sound, Tsao, Patricia A, Shaw, Gloria M, Petersen, Debabrata, Mukhopadhyay, Ronald A, DePinho, Sarah, Thayer, Kamran, Shazand, Timothy, Beck, Michelle, Sam, Lee, Timms, Vanessa, Ballin, Youyong, Lu, Jiafu, Ji, Xiuqing, Zhang, Feng, Chen, Xueda, Hu, Qi, Yang, Geng, Tian, Lianhai, Zhang, Xiaofang, Xing, Xianghong, Li, Zhenggang, Zhu, Yingyan, Yu, Jun, Yu, Jörg, Tost, Paul, Brennan, Ivana, Holcatova, David, Zaridze, Alvis, Brazma, Lars, Egevard, Egor, Prokhortchouk, Rosamonde Elizabeth, Banks, Mathias, Uhlén, Juris, Viksna, Fredrik, Ponten, Konstantin, Skryabin, Ewan, Birney, Ake, Borg, Anne-Lise, Børresen-Dale, Carlos, Caldas, John A, Foekens, Sancha, Martin, Jorge S, Reis-Filho, Andrea L, Richardson, Christos, Sotiriou, Giles, Thoms, Laura, van't Veer, Daniel, Birnbaum, Hélène, Blanche, Pascal, Boucher, Sandrine, Boyault, Jocelyne D, Masson-Jacquemier, Iris, Pauporté, Xavier, Pivot, Anne, Vincent-Salomon, Eric, Tabone, Charles, Theillet, Isabelle, Treilleux, Paulette, Bioulac-Sage, Thomas, Decaens, Dominique, Franco, Marta, Gut, Didier, Samuel, Jessica, Zucman-Rossi, Roland, Eils, Benedikt, Brors, Jan O, Korbel, Andrey, Korshunov, Pablo, Landgraf, Hans, Lehrach, Stefan, Pfister, Bernhard, Radlwimmer, Guido, Reifenberger, Michael D, Taylor, Christof, von Kalle, Partha P, Majumder, Paolo, Pederzoli, Rita A, Lawlor, Massimo, Delledonne, Alberto, Bardelli, Thomas, Gress, David, Klimstra, Giuseppe, Zamboni, Yusuke, Nakamura, Satoru, Miyano, Akihiro, Fujimoto, Elias, Campo, Silvia, de Sanjosé, Emili, Montserrat, Marcos, González-Díaz, Pedro, Jares, Heinz, Himmelbauer, Heinz, Himmelbaue, Silvia, Bea, Samuel, Aparicio, Douglas F, Easton, Francis S, Collins, Carolyn C, Compton, Eric S, Lander, Wylie, Burke, Anthony R, Green, Stanley R, Hamilton, Olli P, Kallioniemi, Timothy J, Ley, Edison T, Liu, Brandon J, Wainwright

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
ResearcherID
Nature, 464(7291), 993-998. Nature Publishing Group
Nature
Nature, Nature Publishing Group, 2010, 464 (7291), pp.993-8. ⟨10.1038/nature08987⟩
Nature; Vol 464
Nature, 464, 993-998
Nature, 464, 7291, pp. 993-998
Dipòsit Digital de la UB
Universidad de Barcelona
Nature, 2010, 464 (7291), pp.993-8. ⟨10.1038/nature08987⟩

International audience; The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumors from 50 different cancer types and/or subtypes that are of clinical and societal importance across the gl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a7f730dcbbde4106a1821bd757c3669
http://hdl.handle.net/10230/36597