Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Mónica A, Costas"'
1
Akademický článek
RAC3 influences the chemoresistance of colon cancer cells through autophagy and apoptosis inhibition
Autor: María Fernanda Rubio, María Cecilia Lira, Francisco Damián Rosa, Adrían Dario Sambresqui, María Cecilia Salazar Güemes, Mónica Alejandra Costas
Publikováno v: Cancer Cell International, Vol 17, Iss 1, Pp 1-17 (2017)
Abstract Background RAC3 coactivator overexpression has been implicated in tumorigenesis, contributing to inhibition of apoptosis and autophagy. Both mechanisms are involved in resistance to treatment with chemotherapeutic agents. The aim of this stu
Externí odkaz: https://doaj.org/article/61f4631d344e46d0b06ebff5714c4736
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2
Akademický článek
The levels of RAC3 expression are up regulated by TNF in the inflammatory response
Autor: Cecilia Viviana Alvarado, María Fernanda Rubio, Pablo Nicolas Fernández Larrosa, Laura Carolina Panelo, Pablo Javier Azurmendi, Marina Ruiz Grecco, Giselle Astrid Martínez-Nöel, Mónica Alejandra Costas
Publikováno v: FEBS Open Bio, Vol 4, Iss C, Pp 450-457 (2014)
RAC3 is a coactivator of glucocorticoid receptor and nuclear factor-κB (NF-κB) that is usually over-expressed in tumors and which also has important functions in the immune system. We investigated the role of the inflammatory response in the contro
Externí odkaz: https://doaj.org/article/1f0b0417a8c6465f853a0c3f31924b5a
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3
Functional relationship between CFTR and RAC3 expression for maintaining cancer cell stemness in human colorectal cancer
Autor: Alejandra Graciela, Palma, Mileni, Soares Machado, María Cecilia, Lira, Francisco, Rosa, María Fernanda, Rubio, Gabriela, Marino, Basilio Aristidis, Kotsias, Mónica Alejandra, Costas
Publikováno v: Cellular oncology (Dordrecht). 44(3)
CFTR mutations not only cause cystic fibrosis, but also increase the risk of colorectal cancer. A putative role of CFTR in colorectal cancer patients without cystic fibrosis has so far, however, not been investigated. RAC3 is a nuclear receptor coact
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2eb4c4cd5b07305941934472ac3a99f4
https://pubmed.ncbi.nlm.nih.gov/33616840
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4
Megakaryocyte-stromal cell interactions: Effect on megakaryocyte proliferation, proplatelet production, and survival
Autor: Nora P. Goette, Francisco R. Borzone, Ailen D. Discianni Lupi, Norma A. Chasseing, María F. Rubio, Mónica A. Costas, Paula G. Heller, Rosana F. Marta, Paola R. Lev
Publikováno v: Experimental hematology. 107
Bone marrow stromal cells provide a proper environment for the development of hematologic lineages. The incorporation of different stromal cells into in vitro culture systems would be an attractive model to study megakaryopoiesis and thrombopoiesis.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0363851127914b63780487307ff20a09
https://pubmed.ncbi.nlm.nih.gov/35032592
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5
Autophagy. A strategy for cell survival
Autor: Mónica A. Costas, María F. Rubio
Publikováno v: Medicina (Buenos Aires), Vol 77, Iss 4, Pp 314-320 (2017)
Autophagy is a process of recycling parts of the cell. As described in this review, it occurs naturally in order to preserve cells from the accumulation of toxins, damaged molecules and organelles, and to allow processes of tissue development and dif
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::e9b75724ef9f82c4365087beba4931d7
http://www.medicinabuenosaires.com/PMID/28825576.pdf
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6
Extract from
Autor: Mileni, Soares Machado, Alejandra, Palma, Laura C, Panelo, Leonardo A, Paz, Francisco, Rosa, María Cecilia, Lira, Pablo, Azurmendi, María F, Rubio, Guido, Lenz, Alejandro J, Urtreger, Mónica A, Costas
Publikováno v: Nutrition and cancer. 72(6)
Cancer stem cells (CSCs) are an important player in the resistance of cancers to therapy. In this work, we determined the flavonoids composition and biological action of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::58e32197aaf244c09e5cb07d39441173
https://pubmed.ncbi.nlm.nih.gov/31573355
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7
Efectos de la rapamicina en los procesos de senescencia y autofagia en líneas celulares humanas
Autor: Pablo N. Fernández Larrosa, Marina Ruiz Grecco, Cecilia V. Alvarado, Sabrina Micenmacher, Cristina Aguirre, Giselle Martínez Nöel, Mónica A. Costas, María Fernanda Rubio
Publikováno v: Medicina (Buenos Aires), Vol 71, Iss 3, Pp 238-242 (2011)
Tanto la autofagia como la senescencia celular son procesos que, en principio, evitan el desarrollo tumoral impidiendo la proliferación de células dañadas. Sin embargo, la autofagia no siempre lleva a la muerte celular, sino que puede ser un mecan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::2eef93288b0ad9aeb618c97697fede4b
http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0025-76802011000500007&lng=en&tlng=en
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8
La sobreexpresión de RAC3 es una señal transformante y proliferativa que contribuye al desarrollo tumoral
Autor: Cecilia V. Alvarado, Sabrina Micenmacher, Marina Ruiz Grecco, María F. Rubio, Nicolás Fernández Larrosa, Mónica A. Costas
Publikováno v: Medicina (Buenos Aires), Vol 71, Iss 1, Pp 33-38 (2011)
RAC3 fue caracterizado originalmente como un coactivador de receptores nucleares que se encuentra en cantidades limitantes en células normales, aunque sobreexpresado en tumores y es además coactivador de NF-?B. Si bien se desconocen los mecanismos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::ad18e216de654cb6e86e665a2daabfe1
http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0025-76802011000100006&lng=en&tlng=en
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9
La actividad transcripcional de NF-kB es diferencialmente regulada por dominios especificos del coactivador TIF2 Different enzymatic activities recruitment by specific domains of TIF2 are involved in NF-kB transactivation
Autor: Ignacio M. Nojek, Santiago E. Werbajh, Georgina P. Colo, Fernanda M. Rubio, Lorena D. Franco, Víctor E. Nahmod, Mónica A. Costas
Publikováno v: Medicina (Buenos Aires), Vol 64, Iss 2, Pp 135-138 (2004)
Demostramos previamente que la sobreexpresión de coactivadores de receptores nucleares aumenta la actividad NF-kB en forma dosis dependiente. Se estudió el mecanismo por el cual el coactivador TIF2 regula la actividad de NF-kB. Determinamos que: 1)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::6828e8fef1f9b70e895acef3fb7ab433
http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0025-76802004000200008
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10
RAC-3 is a NF-κB coactivator
Autor: Santiago E. Werbajh, Mónica A. Costas, Rainer B. Lanz, Ignacio Nojek
Publikováno v: FEBS Lett. 2000;485(2-3):195-199
Biblioteca Digital (UBA-FCEN)
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN
It has been shown that the molecular mechanism by which cytokines and glucocorticoids mutually antagonize their functions involves a mutual glucocorticoid receptor (GR)/nuclear factor-κB (NF-κB) transrepression. Here we report a role for the nuclea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b70519cc8841ce45faba02b3613776
https://doi.org/10.1016/s0014-5793(00)02223-7
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