Hacd2 deficiency in mice leads to an early and lethal mitochondrial disease

Autor: Nahed Khadhraoui, Alexandre Prola, Aymeline Vandestienne, Jordan Blondelle, Laurent Guillaud, Guillaume Courtin, Maxime Bodak, Bastien Prost, Hélène Huet, Mélody Wintrebert, Christine Péchoux, Audrey Solgadi, Frédéric Relaix, Laurent Tiret, Fanny Pilot-Storck

Publikováno v: Molecular Metabolism, Vol 69, Iss , Pp 101677- (2023)

Objective: Mitochondria fuel most animal cells with ATP, ensuring proper energetic metabolism of organs. Early and extensive mitochondrial dysfunction often leads to severe disorders through multiorgan failure. Hacd2 gene encodes an enzyme involved i

Externí odkaz: https://doaj.org/article/6744384a329344d9a39e57dd6832e45f

Exo1 recruits Cdc5 polo kinase to MutLγ to ensure efficient meiotic crossover formation

Autor: Damarys Loew, Mélody Wintrebert, Franz Klein, Xiaojing Mu, Petr Cejka, Bérangère Lombard, Alba Guarné, Scott Keeney, Chun-Long Chen, Jean-Baptiste Charbonnier, Valérie Borde, Lepakshi Ranjha, Yann Duroc, Aurore Sanchez, Stefano Gnan, Céline Adam, Felix Rauh, Raphael Guerois

Publikováno v: Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2020, ⟨10.1073/pnas.2013012117⟩
Proc Natl Acad Sci U S A

International audience; Crossovers generated during the repair of programmed meiotic double-strand breaks must be tightly regulated to promote accurate homolog segregation without deleterious outcomes, such as aneuploidy. The Mlh1-Mlh3 (MutLγ) endon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a94ca3af93779c6105085b1c30ca16d5