Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Mélissanne de Wispelaere"'
Autor:
Mélissanne de Wispelaere, Guangyan Du, Katherine A. Donovan, Tinghu Zhang, Nicholas A. Eleuteri, Jingting C. Yuan, Joann Kalabathula, Radosław P. Nowak, Eric S. Fischer, Nathanael S. Gray, Priscilla L. Yang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Targeted protein degradation (TPD) is a promising strategy for drug development. In this proof-of-concept study, the authors use telaprevir, which binds hepatitis C virus (HCV) NS3/4A protease, to target the protease for protein degradation, and show
Externí odkaz:
https://doaj.org/article/5d5842f94e6549918072db60b50a3ebb
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 1, p e0005294 (2017)
BACKGROUND:Japanese encephalitis virus (JEV) is the causative agent of Japanese encephalitis, the leading cause of viral encephalitis in Asia. JEV transmission cycle involves mosquitoes and vertebrate hosts. The detection of JEV RNA in a pool of Cule
Externí odkaz:
https://doaj.org/article/4634721c946e4014b7a96b876b52239e
Autor:
Mélissanne de Wispelaere, Meret Ricklin, Philippe Souque, Marie-Pascale Frenkiel, Sylvie Paulous, Obdulio Garcìa-Nicolàs, Artur Summerfield, Pierre Charneau, Philippe Desprès
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 10, p e0004081 (2015)
BACKGROUND:Japanese encephalitis virus (JEV) is the major cause of viral encephalitis in Southeast Asia. Vaccination of domestic pigs has been suggested as a "one health" strategy to reduce viral disease transmission to humans. The efficiency of two
Externí odkaz:
https://doaj.org/article/d1fb7a2e2d8943b5836fa9a5571aedd9
Publikováno v:
Protein Homeostasis in Drug Discovery. :465-490
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84dcf29752b0350b6135c625b20116f6
https://doi.org/10.1002/9781119774198.ch14
https://doi.org/10.1002/9781119774198.ch14
Publikováno v:
Phytopathology®. 110:228-236
A hallmark feature of (+)-strand RNA viruses of eukaryotic cells is that progeny (+)-strands are accumulated 100-fold over (−)-strands. Previous experimental evidence suggests that, in Brome mosaic virus (BMV), a plant-infecting member of the alpha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed3e082705520482608d6d28e05c5e55
https://doi.org/10.1094/phyto-07-19-0236-fi
https://doi.org/10.1094/phyto-07-19-0236-fi
Autor:
Jared D. Pitts, Jaebong Jang, Nicholas Kwiatkowski, Pi-Chun Li, Nathanael S. Gray, Wenlong Lian, Chih-Yun Hsia, Mélissanne de Wispelaere, Jinhua Wang, Priscilla L. Yang, Patrice V Groomes
Publikováno v:
ACS infectious diseases. 5(3)
Vaccines and antivirals to combat dengue, Zika, and other flavivirus pathogens present a major, unmet medical need. Vaccine development has been severely challenged by the antigenic diversity of these viruses and the propensity of non-neutralizing, c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08f292792371ebfd823cb6e339601698
https://pubmed.ncbi.nlm.nih.gov/30608640
https://pubmed.ncbi.nlm.nih.gov/30608640
Publikováno v:
Antiviral Research. 147:124-130
The rapid spread of Zika virus (ZIKV) in recent years has highlighted the severe diseases associated with ZIKV infection, such as Guillain-Barré syndrome in adults and microcephaly in newborns; yet no vaccines or antivirals currently exist to preven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bfc208e2c53c08662f7e6dd7be5096b
https://doi.org/10.1016/j.antiviral.2017.10.014
https://doi.org/10.1016/j.antiviral.2017.10.014
Autor:
Nathanael S. Gray, Calla M. Olson, Imme Roggenbach, Margot Carocci, Mélissanne de Wispelaere, Jinhua Wang, Yanke Liang, William J. Neidermyer, Priscilla L. Yang, Sean P. J. Whelan, Dominique J. Burri
Publikováno v:
The Journal of Biological Chemistry
Small-molecule inhibitors of translation are critical tools to study the molecular mechanisms of protein synthesis. In this study, we sought to characterize how QL47, a host-targeted, small-molecule antiviral agent, inhibits steady-state viral protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3435c26a4856db6ba2203993e846bd8d
https://pubmed.ncbi.nlm.nih.gov/31914414
https://pubmed.ncbi.nlm.nih.gov/31914414
Publikováno v:
Phytopathology. 110(1)
A hallmark feature of (+)-strand RNA viruses of eukaryotic cells is that progeny (+)-strands are accumulated 100-fold over (-)-strands. Previous experimental evidence suggests that, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::67a5f03fccb383a1adba2be4df6225e8
https://pubmed.ncbi.nlm.nih.gov/31411546
https://pubmed.ncbi.nlm.nih.gov/31411546
Autor:
Scott B. Ficarro, Jared D. Pitts, Jinhua Wang, Thomas E. Wales, Xuling Zhu, Nathanael S. Gray, Priscilla L. Yang, Wenlong Lian, Mélissanne de Wispelaere, Margaret J. Clark, John R. Engen, Jarrod A. Marto, Jaebong Jang, Jenifer B. Kaplan, Supanee Potisopon, Pi-Chun Li
Viral envelope proteins are required for productive viral entry and initiation of infection. Although the humoral immune system provides ample evidence for targeting envelope proteins as an antiviral strategy, there are few pharmacological interventi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::031e6eb4a07a44ac65d46cecba787d86
https://europepmc.org/articles/PMC6097893/
https://europepmc.org/articles/PMC6097893/
