Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Mélissa Arbour"'
Autor:
Sébastien Gagné, Amandine Chefson, Sylvie Toulmond, Patrick Lacombe, Mélissa Arbour, Austin Chen, Dan McKay, Elizabeth Cauchon, Erich L. Grimm, Yeeman K. Ramtohul, M. David Percival, Jean-François Lévesque, Yves Ducharme, Dwight Macdonald, Yongxin Han, René St-Jacques, Robert Houle, Bruce Mackay, Jean-Pierre Falgueyret, Pierre-André Fournier
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2670-2674
The design and optimization of a novel isoxazole S(1) linker for renin inhibitor is described herein. This effort culminated in the identification of compound 18, an orally bioavailable, sub-nanomolar renin inhibitor even in the presence of human pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb21bf0f8aa1b021cd6fbd529e12bdc
https://doi.org/10.1016/j.bmcl.2012.03.014
https://doi.org/10.1016/j.bmcl.2012.03.014
Publikováno v:
The Journal of Organic Chemistry. 74:3806-3814
We describe the syntheses of (+)-euphococcinine and (-)-adaline, two naturally occurring alkaloids containing a quaternary carbon bearing a nitrogen atom. Key features of the syntheses are a 3,3-sigmatropic rearrangement to give an all-carbon quatern
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f789c2cbb397faa9d05b697d08bde8
https://doi.org/10.1021/jo9001992
https://doi.org/10.1021/jo9001992
Autor:
Weitao Pan, Dan Sherman, Raphael Rios, Sang-phyo Hong, Farah Dhun, Matthew A. J. Duncton, Marc Labelle, Hai-Ying He, Mélissa Arbour, Yong-Jiang Xu, Hu Liu, Joel Kawakami
Publikováno v:
Tetrahedron Letters. 48:8943-8946
Differential reactivity of the amine functionality in a number of common 1,2-diamine starting materials is exploited to undertake an expedient synthesis of unsymmetrical 2,3,6-trisubstituted quinoxaline and unsymmetrical 2,3,7-trisubstituted pyridopy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d9005c303036bb3c81fdb5ed334ad98
https://doi.org/10.1016/j.tetlet.2007.10.117
https://doi.org/10.1016/j.tetlet.2007.10.117
Autor:
Mélissa Arbour, Gavin Chit Tsui, Jean-Pierre Falgueyret, Pierre-André Fournier, Yongxin Han, Michel Gallant, Patrick Lacombe, Daniel Dube, Daniel Simard, Elizabeth Cauchon, Austin Chen, Renee Aspiotis, Suzanna Liu, René St-Jacques, Christophe Mellon, Erich L. Grimm, Yeeman K. Ramtohul, Helene Juteau
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(5)
The discovery and SAR of a series of potent renin inhibitors possessing a novel 3,4-diarylpiperidine scaffold are described herein. The resulting compound 38 exhibit low nanomolar plasma renin IC(50), had a clean CYP 3A4 profile and displayed micromo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72bbcef3547c253b1c7b45e16084feb3
https://pubmed.ncbi.nlm.nih.gov/22325946
https://pubmed.ncbi.nlm.nih.gov/22325946
Publikováno v:
The Journal of organic chemistry. 70(15)
Highly hindered and sensitive isocyanates react with alcohols under mild catalysis by titanium tetra-t-butoxide to give high yields of the corresponding carbamates.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90bc74947f7a55d988017703a3860601
https://pubmed.ncbi.nlm.nih.gov/16018715
https://pubmed.ncbi.nlm.nih.gov/16018715