A novel method to detect hPG80 (human circulating progastrin) in the blood

Autor: Berengere Vire, Julien Soulé, Veronique Saywell, Lucile Canterel-Thouennon, Sylvia Tigrett, Erika Ortiz, Mélina Blairvacq, Emilie Blanc, Dominique Joubert, Alexandre Prieur, Maud Flacelière, Sophie Poupeau, Fanny Belouin, Pierre Liaud, Monica Cappellini

Publikováno v: Analytical Methods. 13:4468-4477

hPG80 (human circulating progastrin) is produced and released by cancer cells. We recently reported that hPG80 is detected in the blood of patients with cancers from different origins, suggesting its potential utility for cancer detection. To accurat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1edc1e9d0fef2f0710c13012fd8cfc81
https://doi.org/10.1039/d1ay00986a

Prognostic Value of Plasma hPG80 (Circulating Progastrin) in Metastatic Renal Cell Carcinoma

Autor: Daniel Rouison, Manish Kohli, Thierry Cousin, Pierre Liaud, George Garnier, Frederic Berthier, Mélina Blairvacq, Dominique Joubert, Berengere Vire, Léa Payen, Winston Tan, Alexandre Prieur

Publikováno v: Cancers
Volume 13
Issue 3
Cancers, Vol 13, Iss 375, p 375 (2021)

Precise management of kidney cancer requires the identification of prognostic factors. hPG80 (circulating progastrin) is a tumor promoting peptide present in the blood of patients with various cancers, including renal cell carcinoma (RCC). In this st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55203daeb0428300383f23a97d4db325

Further investigation of Paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors

Autor: Mélina Blairvacq, Olivier Lozach, Christophe Labrière, Laurent Meijer, Catherine Guillou

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2016, 124, pp.920-934. ⟨10.1016/j.ejmech.2016.08.069⟩
European Journal of Medicinal Chemistry, 2016, 124, pp.920-934. ⟨10.1016/j.ejmech.2016.08.069⟩

International audience; Starting from a known compound, identified as the first inhibitor of the kinesin MKLP-2 and named Paprotrain, we have investigated its reactivity to produce through photochemistry a potent nanomolar inhibitor of the kinase DYR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3fd3248a79d43ef381e4337bccb7c6c
https://hal.univ-brest.fr/hal-01517780

Novel 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitrile derivatives as dual cyclin-dependent kinase 1 (CDK1)/glycogen synthase kinase-3 (GSK-3) inhibitors: Synthesis, biological evaluation and molecular modeling studies

Autor: Alexandra Testard, Cédric Logé, Olivier Lozach, Laurent Meijer, Mélina Blairvacq, Thierry Besson, Jean-Michel Robert, Valérie Thiéry

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2008, 43 (7), pp.1469-1477. ⟨10.1016/j.ejmech.2007.09.020⟩

Continuous efforts in microwave-assisted synthesis and the structure-activity relationships' (SARs) studies of novel modified 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitriles, allowed identification of new amidine and imidate derivatives as potent an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::089eb8121f3b422138e99a715209101c
https://doi.org/10.1016/j.ejmech.2007.09.020

Synthesis of novel 5-substituted indirubins as protein kinases inhibitors

Autor: Anne Beauchard, Olivier Lozach, Thierry Besson, Laurent Meijer, Mélina Blairvacq, Valérie Thiéry, Yoan Ferandin, Stéphane Frère

Publikováno v: Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, 2006, 14 (18), pp.6434-43. ⟨10.1016/j.bmc.2006.05.036⟩
Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2006, 14 (18), pp.6434-6443. ⟨10.1016/j.bmc.2006.05.036⟩
Bioorganic and Medicinal Chemistry Letters, 2006, 14 (18), pp.6434-6443. ⟨10.1016/j.bmc.2006.05.036⟩
Bioorganic and Medicinal Chemistry, Elsevier, 2006, 14 (18), pp.6434-43. ⟨10.1016/j.bmc.2006.05.036⟩

In an effort to identify new pharmacological inhibitors of disease-relevant protein kinases with increased potency and selectivity, we synthesized and evaluated new 5-substituted indirubins. The effects of 34 indirubin derivatives on CDK1/cyclin B, C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d965ae963876b84e60cc84b3e8b79b7
https://doi.org/10.1016/j.bmc.2006.05.036