Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Mélia Magnen"'
Autor:
Daniel R. Calabrese, Tasha Tsao, Mélia Magnen, Colin Valet, Ying Gao, Beñat Mallavia, Jennifer J. Tian, Emily A. Aminian, Kristin M. Wang, Avishai Shemesh, Elman B. Punzalan, Aartik Sarma, Carolyn S. Calfee, Stephanie A. Christenson, Charles R. Langelier, Steven R. Hays, Jeffrey A. Golden, Lorriana E. Leard, Mary Ellen Kleinhenz, Nicholas A. Kolaitis, Rupal Shah, Aida Venado, Lewis L. Lanier, John R. Greenland, David M. Sayah, Abbas Ardehali, Jasleen Kukreja, S. Samuel Weigt, John A. Belperio, Jonathan P. Singer, Mark R. Looney
Publikováno v:
JCI Insight, Vol 7, Iss 24 (2022)
Clinical outcomes after lung transplantation, a life-saving therapy for patients with end-stage lung diseases, are limited by primary graft dysfunction (PGD). PGD is an early form of acute lung injury with no specific pharmacologic therapies. Here, w
Externí odkaz:
https://doaj.org/article/1ce137fa246e4f4d9647ad53ba99ced1
Autor:
Colin Valet, Mélia Magnen, Longhui Qiu, Simon J. Cleary, Kristin M. Wang, Serena Ranucci, Elodie Grockowiak, Rafik Boudra, Catharina Conrad, Yurim Seo, Daniel R. Calabrese, John R. Greenland, Andrew D. Leavitt, Emmanuelle Passegué, Simón Méndez-Ferrer, Filip K. Swirski, Mark R. Looney
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 7 (2022)
Platelets have a wide range of functions including critical roles in hemostasis, thrombosis, and immunity. We hypothesized that during acute inflammation, such as in life-threatening sepsis, there are fundamental changes in the sites of platelet prod
Externí odkaz:
https://doaj.org/article/c6be936c86a64996bba945d179a280f3
Autor:
Catharina Conrad, Daniela Yildiz, Simon J. Cleary, Andreas Margraf, Lena Cook, Uwe Schlomann, Barry Panaretou, Jessica L. Bowser, Harry Karmouty-Quintana, Jiwen Li, Nathaniel K. Berg, Samuel C. Martin, Ahmad Aljohmani, S. Farshid Moussavi-Harami, Kristin M. Wang, Jennifer J. Tian, Mélia Magnen, Colin Valet, Longhui Qiu, Jonathan P. Singer, Holger K. Eltzschig, CAPSys Study Group, Wilhelm Bertrams, Susanne Herold, Norbert Suttorp, Bernd Schmeck, Zachary T. Ball, Alexander Zarbock, Mark R. Looney, Jörg W. Bartsch
Publikováno v:
JCI Insight, Vol 7, Iss 3 (2022)
Acute respiratory distress syndrome (ARDS) results in catastrophic lung failure and has an urgent, unmet need for improved early recognition and therapeutic development. Neutrophil influx is a hallmark of ARDS and is associated with the release of ti
Externí odkaz:
https://doaj.org/article/254cf7c552124bd6aa63f41af70b7891
Autor:
Yurim Seo, Longhui Qiu, Mélia Magnen, Catharina Conrad, S. Farshid Moussavi-Harami, Mark R Looney, Simon J Cleary
Publikováno v:
bioRxiv
Microbes, toxins, therapeutics and cells are often instilled into lungs of mice to model diseases and test experimental interventions. Consistent pulmonary delivery is critical for experimental power and reproducibility, but we observed variation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f3b90ff21318f1aaa70cf90aa53232
https://doi.org/10.1101/2023.02.01.526706
https://doi.org/10.1101/2023.02.01.526706
Autor:
Clive P. Page, Mark R. Looney, Mélia Magnen, Elaine Gray, Richard T. Amison, Simon J. Cleary, Simon C. Pitchford, C. Lorena Robaina Cabrera, Robert Carrington
Publikováno v:
British Journal of Pharmacology
The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 infections has led to a substantial unmet need for treatments, many of which will require testing in appropriate animal models of this disease. Vaccine trials are already underway,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3462f390ec2a55f66ec0186db2eb3786
https://doi.org/10.1111/bph.15143
https://doi.org/10.1111/bph.15143
Autor:
Yambasu A. Brewah, Thomas Baranek, Damien Sizaret, Fabien Gueugnon, Agnès Petit-Courty, Mélia Magnen, Mustapha Si-Tahar, Alison A. Humbles, Yves Courty
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology
American Journal of Physiology-Lung Cellular and Molecular Physiology, American Physiological Society, 2019, 316 (6), pp.L1127-L1140. ⟨10.1152/ajplung.00379.2018⟩
American Journal of Physiology-Lung Cellular and Molecular Physiology, American Physiological Society, 2019, 316 (6), pp.L1127-L1140. ⟨10.1152/ajplung.00379.2018⟩
International audience; Host cell proteases are involved in influenza pathogenesis. We examined the role of tissue kallikrein 1 (KLK1) by comparing wild-type (WT) and KLK1-deficient mice infected with influenza H3N2 virus. The levels of KLK1 in lung
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299d162c015d17a94fca0bba8947ecad
https://doi.org/10.1152/ajplung.00379.2018
https://doi.org/10.1152/ajplung.00379.2018
Autor:
Kwok W. Im, Wandi S Zhu, Carolyn S. Calfee, Sidney A. Carrillo, Colin R. Zamecnik, Nayvin W. Chew, Aleksandra Leligdowicz, Jessica Tsui, Gabriella C Reeder, Charles Langelier, Mélia Magnen, Yang Sun, David Lee, Nicholas F. Kuhn, Nina K. Serwas, William S. Chen, Simon J. Cleary, Carolyn M. Hendrickson, David J. Erle, Mark R. Looney, Alexis J. Combes, Alan Shen, Kirsten N. Kangelaris, Kenneth H. Hu, Arja Ray, Arjun A. Rao, Alyssa Ward, Michael A. Matthay, Lauren Rodriguez, Gabriela K. Fragiadakis, Ran You, Chun Jimmie Ye, Priscila Muñoz-Sandoval, Kamir J Hiam-Galvez, Vincent Chan, Divyashree Kushnoor, Michael R. Wilson, Matthew F. Krummel, Prescott G. Woodruff, Rita P. Loudermilk, Tristan Courau
Publikováno v:
Nature
Although infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has pleiotropic and systemic effects in some individuals1-3, many others experience milder symptoms. Here, to gain a more comprehensive understanding of the distinct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f02e5306407636edf6c7084f7d2d3999
Autor:
Carolyn S. Calfee, Wandi S Zhu, Nicholas F. Kuhn, Aleksandra Leligdowicz, Mark R. Looney, Alexis J. Combes, Alyssa Ward, Divyashree Kushnoor, Michael R. Wilson, David Lee, Kenneth H. Hu, Arja Ray, William S. Chen, Carolyn M. Hendrickson, Lauren Rodriguez, David J. Erle, Kirsten N. Kangelaris, Colin R. Zamecnik, Nayvin W. Chew, Jessica Tsui, Gabriella C Reeder, Arjun A. Rao, Kamir J Hiam-Galvez, Yang Sun, Prescott G. Woodruff, Simon J. Cleary, Michael A. Matthay, Chun Jimmie Ye, Ran You, Gabriela K. Fragiadakis, Sidney A. Carrillo, Alan Shen, Priscila Muñoz-Sandoval, Tristan Courau, Charles Langelier, Vincent Chan, Rita P. Loudermilk, Mélia Magnen, Matthew F. Krummel
Publikováno v:
bioRxiv
Research Square
article-version (status) pre
article-version (number) 1
Research Square
article-version (status) pre
article-version (number) 1
While SARS-CoV-2 infection has pleiotropic and systemic effects in some patients, many others experience milder symptoms. We sought a holistic understanding of the severe/mild distinction in COVID-19 pathology, and its origins. We performed a whole-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7154dfd5941d35d9842e8ebca64017d
https://europepmc.org/articles/PMC7605559/
https://europepmc.org/articles/PMC7605559/
Publikováno v:
Br J Pharmacol
British Journal of Pharmacology
British Journal of Pharmacology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2afe369010c5ef921bc96052429b8718
https://pubmed.ncbi.nlm.nih.gov/33140409
https://pubmed.ncbi.nlm.nih.gov/33140409
Autor:
Elaine Gray, Simon C. Pitchford, Simon J. Cleary, Robert Carrington, C. Lorena Robaina Cabrera, Mark R. Looney, Richard T. Amison, Mélia Magnen, Clive P. Page
The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 infections has led to substantial unmet need for treatments, many of which will require testing in appropriate animal models of this disease. Vaccine trials are already underway, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::730aa26044636eb50251d2829b95b422
https://doi.org/10.22541/au.158861365.54417186
https://doi.org/10.22541/au.158861365.54417186