Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Mélanie Vivancos"'
1
Akademický článek
Freely Behaving Mice Can Brake and Turn During Optogenetic Stimulation of the Mesencephalic Locomotor Region
Autor: Cornelis Immanuel van der Zouwen, Joël Boutin, Maxime Fougère, Aurélie Flaive, Mélanie Vivancos, Alessandro Santuz, Turgay Akay, Philippe Sarret, Dimitri Ryczko
Publikováno v: Frontiers in Neural Circuits, Vol 15 (2021)
A key function of the mesencephalic locomotor region (MLR) is to control the speed of forward symmetrical locomotor movements. However, the ability of freely moving mammals to integrate environmental cues to brake and turn during MLR stimulation is p
Externí odkaz: https://doaj.org/article/1b93e52767c84c2288bd16fe32f2df48
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2
Akademický článek
Insightful Backbone Modifications Preventing Proteolytic Degradation of Neurotensin Analogs Improve NTS1-Induced Protective Hypothermia
Autor: Santo Previti, Mélanie Vivancos, Emmanuelle Rémond, Sabrina Beaulieu, Jean-Michel Longpré, Steven Ballet, Philippe Sarret, Florine Cavelier
Publikováno v: Frontiers in Chemistry, Vol 8 (2020)
Therapeutic hypothermia represents a brain-protective strategy for multiple emergency situations, such as stroke or traumatic injury. Neurotensin (NT), which exerts its effects through activation of two G protein-coupled receptors, namely NTS1 and NT
Externí odkaz: https://doaj.org/article/839615fc8b2141cbb06a47c9cfe1d1fc
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3
Optimized Opioid-Neurotensin Multitarget Peptides: From Design to Structure-Activity Relationship Studies
Autor: Simon Gonzalez, Dirk Tourwé, Philippe Sarret, Mariana Spetea, Florine Cavelier, Santo Previti, Charlotte Martin, Linda Kunze, Mélanie Vivancos, Stevany Louis, Louis Gendron, Elke Dewolf, Maria Dumitrascuta, Steven Ballet, Emilie Eiselt, Annalisa Blasiol
Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2020, 63 (21), pp.12929-12941. ⟨10.1021/acs.jmedchem.0c01376⟩
International audience; Fusion of nonopioid pharmacophores, such as neurotensin, with opioid ligands represents an attractive approach for pain treatment. Herein, the μ-/δ-opioid agonist tetrapeptide H-Dmt-D-Arg-Aba-β-Ala-NH 2 (KGOP01) was fused t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d847dbf764c975a594956d0282309fc
https://biblio.vub.ac.be/vubir/optimized-opioidneurotensin-multitarget-peptides-from-design-to-structureactivity-relationship-studies(b5565787-3be0-4e48-8dac-9092ed30584e).html
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4
Metabolically stable neurotensin analogs exert potent and long-acting analgesia without hypothermia
Autor: Martin Resua-Rojas, Magali Chartier, Christine E. Mona, Philippe Sarret, Jean-Michel Longpré, Florine Cavelier, Emmanuelle Rémond, Roberto Fanelli, Élie Besserer-Offroy, Santo Previti, Sabrina Beaulieu, Mélanie Vivancos
Publikováno v: Behavioural Brain Research
Behavioural Brain Research, Elsevier, 2021, 405, pp.113189. ⟨10.1016/j.bbr.2021.113189⟩
The endogenous tridecapeptide neurotensin (NT) has emerged as an important inhibitory modulator of pain transmission, exerting its analgesic action through the activation of the G protein-coupled receptors, NTS1 and NTS2. Whereas both NT receptors me
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed347f68c55b4b7e454ccf95ac1cd132
https://pubmed.ncbi.nlm.nih.gov/33607165
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5
Insightful Backbone Modifications Preventing Proteolytic Degradation of Neurotensin Analogs Improve NTS1-Induced Protective Hypothermia
Autor: Steven Ballet, Sabrina Beaulieu, Jean-Michel Longpré, Mélanie Vivancos, Santo Previti, Florine Cavelier, Philippe Sarret, Emmanuelle Rémond
Publikováno v: Frontiers in Chemistry, Vol 8 (2020)
Frontiers in Chemistry
Frontiers in Chemistry, Frontiers Media, 2020, ⟨10.3389/fchem.2020.00406⟩
Therapeutic hypothermia represents a brain-protective strategy for multiple emergency situations, such as stroke or traumatic injury. Neurotensin (NT), which exerts its effects through activation of two G protein-coupled receptors, namely NTS1 and NT
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::425b8c982afc663b3cf9a5898a60b884
https://www.frontiersin.org/article/10.3389/fchem.2020.00406/full
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7
Structural Optimization and Characterization of Potent Analgesic Macrocyclic Analogues of Neurotensin (8–13)
Autor: Marc Sousbie, Philippe Sarret, Rebecca L. Brouillette, Eric Marsault, Élie Besserer-Offroy, Jean-Michel Longpré, Mélanie Vivancos, Richard Leduc
Publikováno v: Journal of Medicinal Chemistry. 61:7103-7115
The neurotensin receptors are attractive targets for the development of new analgesic compounds. They represent potential alternatives or adjuvants to opioids. Herein, we report the structural optimization of our recently reported macrocyclic peptide
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a42c74d03c2c87ef1de80c1a0ef88f73
https://doi.org/10.1021/acs.jmedchem.8b00175
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9
Use of Molecular Modeling to Design Selective NTS2 Neurotensin Analogues
Autor: Mélanie Vivancos, Jean-Michel Longpré, Jean Martinez, Bartholomé Delort, Philippe Sarret, Florine Cavelier, Roberto Fanelli, Élie Besserer-Offroy, Nicolas Floquet, Pedro Renault
Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2017, 60 (8), pp.3303-3313. ⟨10.1021/acs.jmedchem.6b01848⟩
Neurotensin exerts potent analgesia by acting at both NTS1 and NTS2 receptors, whereas NTS1 activation also results in other physiological effects such as hypotension and hypothermia. Here, we used molecular modeling approach to design highly selecti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b35e41d32c7d9229a7fa1dee6445d9
https://hal.archives-ouvertes.fr/hal-02322191
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