Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Mélanie Op"'
Autor:
Claire Chavarria, Léa Zaffalon, Sérgio T. Ribeiro, Mélanie Op, Manfredo Quadroni, Maria Sofia Iatrou, Chloé Chapuis, Fabio Martinon
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107777- (2023)
Summary: The transcription factor NRF1 resides in the endoplasmic reticulum (ER) and is constantly transported to the cytosol for proteasomal degradation. However, when the proteasome is defective, NRF1 escapes degradation and undergoes proteolytic c
Externí odkaz:
https://doaj.org/article/87380d337ae94b5ea085be4db259854f
Autor:
Mélanie Op, Sérgio T. Ribeiro, Claire Chavarria, Aude De Gassart, Léa Zaffalon, Fabio Martinon
Publikováno v:
Cell Death and Disease, Vol 13, Iss 5, Pp 1-9 (2022)
Abstract Proteasome inhibitors, such as bortezomib, are first-line therapy against multiple myeloma (MM). Unfortunately, patients frequently become refractory to this treatment. The transcription factor NRF1 has been proposed to initiate an adaptatio
Externí odkaz:
https://doaj.org/article/10309f0b4ce3404ea5315eee0b0d5115
Autor:
Sérgio T. Ribeiro, Aude de Gassart, Sarah Bettigole, Lea Zaffalon, Claire Chavarria, Melanie Op, Kalvin Nugraha, Fabio Martinon
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105227- (2022)
Summary: DNA-damage inducible 1 homolog 2 (DDI2) is a protease that activates the transcription factor NRF1. Cellular models have shown that this pathway contributes to cell-stress adaptation, for example, on proteasome inhibition. However, DDI2 phys
Externí odkaz:
https://doaj.org/article/644a98c71d744459bd626a2b2cd07225