Výsledky vyhledávání - "Mélanie Kuntz"

Diesel Exhaust Particles Impair Endothelial Progenitor Cells Compromise Endothelial Integrity Reduce Neoangiogenesis and Increase Atherogenesis in Mice

Autor: Ulrich Laufs, Martin Mempel, Francesca Alessandrini, Janine Pöss, Valerie Pavlikova, Thimoteus Speer, Christian Werner, Dominik Lorenz, Mélanie Kuntz, Matthias Endres, Vincent Berezowski, Michael Böhm, Christoph Gensch

Publikováno v: Cardiovascular Toxicology; Vol 13
Cardiovascular Toxicology
Cardiovascular Toxicology, Humana Press, 2013, 13 (3), pp.290-300. ⟨10.1007/s12012-013-9208-0⟩

International audience; The mechanisms of the harmful cardiovascular effects of small particulate matter are incompletely understood. Endothelial progenitor cells (EPCs) predict outcome of patients with vascular disease. The aim of our study was to e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a5b329aa9a091864d30c8ba7079e188

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Bexarotene Promotes Cholesterol Efflux and Restricts Apical-to-Basolateral Transport of Amyloid-β Peptides in an In Vitro Model of the Human Blood-Brain Barrier

Autor: Marie-Christine Boucau, Laurence Fenart, Yordenca Lamartiniere, Julien Saint-Pol, Emmanuel Sevin, Pietra Candela, Mélanie Kuntz, Fabien Gosselet

Publikováno v: Journal of Alzheimer's Disease
Journal of Alzheimer's Disease, IOS Press, 2015, 48 (3), pp.849-862. ⟨10.3233/JAD-150469⟩

International audience; One of the prime features of Alzheimer's disease (AD) is the excessive accumulation of amyloid-β (Aβ) peptides in the brain. Several recent studies suggest that this phenomenon results from the dysregulation of cholesterol h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72635e9f5f60eedc64e8d31a2b229e9f
https://hal-univ-artois.archives-ouvertes.fr/hal-02513306

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Protein kinase C restricts transport of carnitine by amino acid transporter ATB0,+ apically localized in the blood–brain barrier

Autor: Katarzyna A. Nałęcz, Grzegorz M. Wilczynski, Roméo Cecchelli, Mélanie Kuntz, Andrzej A. Szczepankiewicz, Vincent Berezowski, Caroline Mysiorek, Katarzyna Michalec

Publikováno v: Archives of Biochemistry and Biophysics
Archives of Biochemistry and Biophysics, Elsevier, 2014, 554, pp.28-35. ⟨10.1016/j.abb.2014.05.006⟩

International audience; Carnitine (3-hydroxy-4-trimethylammoniobutyrate) is necessary for transfer of fatty acids through the inner mitochondrial membrane. Carnitine, not synthesized in the brain, is delivered there through the strongly polarized blo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe0b515ce21d765ba17fd387aa1e902
https://hal-univ-artois.archives-ouvertes.fr/hal-02515246

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Stroke-Induced Brain Parenchymal Injury Drives Blood–Brain Barrier Early Leakage Kinetics: A Combined in Vivo / in Vitro Study

Autor: Mélanie Kuntz, Rustem Uzbekov, Vincent Berezowski, Olivier Pétrault, Régis Bordet, Laurence Fenart, Roméo Cecchelli, Maud Pétrault, Caroline Mysiorek

Publikováno v: Journal of Cerebral Blood Flow and Metabolism
Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2014, 34 (1), pp.95-107. ⟨10.1038/jcbfm.2013.169⟩
Journal of Cerebral Blood Flow & Metabolism; Vol 34

International audience; The disappointing clinical outcomes of neuroprotectants challenge the relevance of preclinical stroke models and data in defining early cerebrovascular events as potential therapeutic targets. The kinetics of blood–brain bar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1262bbcc8388a7026fec7685ba017ba5
https://hal-univ-artois.archives-ouvertes.fr/hal-02515289

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Transient oxygen–glucose deprivation sensitizes brain capillary endothelial cells to rtPA at 4h of reoxygenation

Autor: Mélanie Kuntz, Caroline Mysiorek, Olivier Pétrault, Rachid Aijjou, Vincent Berezowski, Marie-Christine Boucau, Rustem Uzbekov

Publikováno v: Microvascular Research
Microvascular Research, Elsevier, 2014, 91, pp.44-57. ⟨10.1016/j.mvr.2013.12.002⟩
Microvascular Research; Vol 91

International audience; Thrombolysis treatment of acute ischemic stroke is limited by the pro-edematous and hemorrhagic effects exerted by reperfusion, which disrupts the blood-brain barrier (BBB) capillary endothelium in the infarct core. Most studi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac7f7c53c80a6f131573bef413b3e0df
https://hal-univ-artois.archives-ouvertes.fr/hal-02515279

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Prevention of rt-PA induced blood–brain barrier component degradation by the poly(ADP-ribose)polymerase inhibitor PJ34 after ischemic stroke in mice

Autor: Frédéric Szeremeta, Niamh Slane, Marie Garraud, Isabelle Margaill, Bérard Coqueran, Catherine Marchand-Leroux, Michel Plotkine, Mélanie Kuntz, Clémentine Lesbats, Vincent Berezowski, Virginie Beray-Berthat, Daniel Scherman, Fei Teng, Cyrielle Bedfert, Bich-Thuy Doan, Bruno Palmier, Johan Hachani

Publikováno v: Experimental Neurology
Experimental Neurology, Elsevier, 2013, 248, pp.416-428. ⟨10.1016/j.expneurol.2013.07.007⟩

International audience; Recombinant tissue plasminogen activator (rt-PA) is the only pharmacological treatment approved for thrombolysis in patients suffering from ischemic stroke, but its administration aggravates the risk of hemorrhagic transformat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4006c252fefd62ef67f5ddd473531dd5
https://hal.archives-ouvertes.fr/hal-02070926

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[Dysfunction of the blood-brain barrier during ischaemia: a therapeutic concern]

Autor: Vincent, Bérézowski, Caroline, Mysiorek, Mélanie, Kuntz, Olivier, Pétrault, Roméo, Cecchelli

Publikováno v: Biologie aujourd'hui. 206(3)

Since it was discovered and its brain-protective role characterized, the blood-brain barrier (BBB), through the permeability-restricting action of the brain capillary endothelial cells, has been representing a hurdle for 95% of new medical compounds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1e2071148f211e805bbe78b9505052a1
https://pubmed.ncbi.nlm.nih.gov/23171839

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Interactions between vascular cells and neuron-glial cells in the developing central nervous system under hypoxia in vitro

Autor: Melina Rapacioli, Mélanie Kuntz, Lucie Dehouck, Vincent Berezowski, Vladimir Flores, Alejandra Rodriguez Celin

Publikováno v: Developmental Biology. (1):145-146

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0d3ae041419ba247fb093d6346f2a4

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