Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Mélanie Gaignage"'
1
Akademický článek
Selective inhibition of TGF-β1 produced by GARP-expressing Tregs overcomes resistance to PD-1/PD-L1 blockade in cancer
Autor: Grégoire de Streel, Charlotte Bertrand, Nicolas Chalon, Stéphanie Liénart, Orian Bricard, Sara Lecomte, Julien Devreux, Mélanie Gaignage, Gitte De Boeck, Lore Mariën, Inge Van De Walle, Bas van der Woning, Michael Saunders, Hans de Haard, Elien Vermeersch, Wim Maes, Hans Deckmyn, Pierre G. Coulie, Nicolas van Baren, Sophie Lucas
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Inhibiting TGF-β1 to increase immune responses against tumors bears the risk of tumor-promoting toxicity. Here the authors show that selectively blocking TGF-β1 produced by immunosuppressive cells is feasible with anti-GARP:TGF-β1 antibodies and i
Externí odkaz: https://doaj.org/article/8a55d3ad04c940c5ae3df3fd9a81d1dc
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2
Akademický článek
The TLR7 ligand R848 prevents mouse graft-versus-host disease and cooperates with anti-interleukin-27 antibody for maximal protection and regulatory T-cell upregulation
Autor: Mélanie Gaignage, Reece G. Marillier, Perrine M. Cochez, Laure Dumoutier, Catherine Uyttenhove, Jean-Paul Coutelier, Jacques Van Snick
Publikováno v: Haematologica, Vol 104, Iss 2 (2019)
In spite of considerable therapeutic progress, acute graft-versus-host disease still limits allogeneic hematopoietic cell transplantation. We recently reported that mouse infection with nidovirus lactate dehydrogenase elevating virus impairs disease
Externí odkaz: https://doaj.org/article/422fcf45535c43e9a8ec9212d0bb09f3
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3
Blocking GARP-mediated activation of TGF-β1 did not alter innate or adaptive immune responses to bacterial infection or protein immunization in mice
Autor: Mélanie Gaignage, Xuhao Zhang, Julie Stockis, Olivier Dedobbeleer, Camille Michiels, Perrine Cochez, Laure Dumoutier, Pierre G. Coulie, Sophie Lucas
Publikováno v: Cancer immunology, immunotherapy : CII, Vol. 00, no.00, p. 00 (2022)
Transmembrane protein GARP binds latent TGF-β1 to form GARP:(latent)TGF-β1 complexes on the surface of several cell types including Tregs, B-cells, and platelets. Upon stimulation, these cells release active TGF-β1. Blocking TGF-β1 activation by
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65823b2185ada761050520ef685d8b53
https://hdl.handle.net/2078.1/258446
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4
Involvement of virus-induced interferon production in IgG autoantibody-mediated anemia
Autor: Shozo Izui, Dan Su, Cor Breukel, J. Sjef Verbeek, Jill W. C. Claassens, Mélanie Gaignage, Conny Brouwers, Jean-Paul Coutelier, Margot M. Linssen, Sarah Legrain
Publikováno v: International Journal of Molecular Sciences, 22(16). MDPI
International Journal of Molecular Sciences
Volume 22
Issue 16
International Journal of Molecular Sciences, Vol 22, Iss 9027, p 9027 (2021)
Infection with viruses, such as the lactate dehydrogenase-elevating virus (LDV), is known to trigger the onset of autoimmune anemia through the enhancement of the phagocytosis of autoantibody-opsonized erythrocytes by activated macrophages. Type I in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aebe3f03de742beeb5288e00b271c01
https://hdl.handle.net/1887/3213013
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5
Novel antibodies that selectively block mouse IL-12 enable the re-evaluation of the role of IL-12 in immune protection and pathology
Autor: Christophe Bourdeaux, Paméla Chéou, Mohamed F. Mandour, Mélanie Gaignage, Jacques Van Snick, Lindsay L. Jones, Catherine Uyttenhove, Dario A. A. Vignali, Jean-Paul Coutelier
Publikováno v: European Journal of Immunolgy, Vol. 51, no.6, p. 1482-1493 (2021)
The dimeric cytokine IL-12 is important in the control of various infections but also contributes to the pathology of certain diseases making it a potential target for therapy. However, its specific inhibition with antibodies is complicated by the fa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2edb6e6d82cf064498184496b7f1e8aa
https://pubmed.ncbi.nlm.nih.gov/33788263
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7
Selective inhibition of TGF-β1 produced by GARP-expressing Tregs overcomes resistance to PD-1/PD-L1 blockade in cancer
Autor: Nicolas van Baren, Bas van der Woning, Grégoire de Streel, Gitte De Boeck, Hans Deckmyn, Sara Lecomte, Nicolas Chalon, Elien Vermeersch, Julien Devreux, Inge Van de Walle, Pierre Coulie, Hans de Haard, Mélanie Gaignage, Lore Mariën, Sophie Lucas, Wim Maes, Michael A. Saunders, Stéphanie Liénart, Charlotte Bertrand, Orian Bricard
Publikováno v: Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature communications, Vol. 11, no.1, p. 4545 (2020)
TGF-β1, β2 and β3 bind a common receptor to exert vastly diverse effects in cancer, supporting either tumor progression by favoring metastases and inhibiting anti-tumor immunity, or tumor suppression by inhibiting malignant cell proliferation. Glo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa2005dc0e4b4cc34d21601ace80f2b
https://pubmed.ncbi.nlm.nih.gov/32917858
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8
Prophylactic treatment against GM-CSF, but not IL-17, abolishes relapses in a chronic murine model of multiple sclerosis
Autor: Dominique Donckers, Vincent Van Pesch, Catherine Uyttenhove, Paméla Chéou, Ludovic D'Auria, Zakia Nasr, Mélanie Gaignage, Jacques Van Snick
Publikováno v: European journal of immunology, (2018)
The pathogenic role of IL-17 and GM-CSF has been unravelled in experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). However, in most models, EAE is characterised by a monophasic attack which is not representativ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e15428dbd6223db07101c03d6d6cb620
https://doi.org/10.1002/eji.201847580
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9
Mouse nidovirus LDV infection alleviates graft versus host disease and induces type I IFN-dependent inhibition of dendritic cells and allo-responsive T cells
Autor: Nicolas Dauguet, Thomas Michiels, Mélanie Gaignage, Bernard Ryffel, Reece Gerrad Marillier, Jacques Van Snick, Jean-Paul Coutelier, Catherine Uyttenhove, Anubha Saxena
Publikováno v: Immunity, Inflammation and Disease. 5:200-213
Introduction Viruses have developed multiple mechanisms to alter immune reactions. In 1969, it was reported that lactate dehydrogenase-elevating virus (LDV), a single stranded positive sense mouse nidovirus, delays skin allograft rejection and inhibi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e009fcf80d5352f1646a0de9cc096cb
https://doi.org/10.1002/iid3.157
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10
Blockade of interleukin-27 signaling reduces GVHD in mice by augmenting Treg reconstitution and stabilizing Foxp3 expression
Autor: Daniel Eastwood, Calvin B. Williams, Cheng Yin-Yuan, Jacques Van Snick, Nico Ghilardi, Kimberle A. Agle, Vivian Zhou, Reece G Marillier, Richard A. Komorowski, Ludovic Belle, Daniel J. Cua, Jie Sun, Brent R. Logan, William R. Drobyski, Mélanie Gaignage
Publikováno v: Blood. 128:2068-2082
Reestablishment of competent regulatory pathways has emerged as a strategy to reduce the severity of graft-versus-host disease (GVHD), and recalibrate the effector and regulatory arms of the immune system. However, clinically feasible, cost-effective
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e391d90a3f159ff8f555464dd9aa76
https://doi.org/10.1182/blood-2016-02-698241
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