Evidence for post-translational processing of vascular endothelial (VE)-cadherin in brain tumors: towards a candidate biomarker.

Autor: Isabelle Vilgrain, Adama Sidibé, Helena Polena, Francine Cand, Tiphaine Mannic, Mélanie Arboleas, Sandra Boccard, Antoine Baudet, Danielle Gulino-Debrac, Laurence Bouillet, Jean-Louis Quesada, Christophe Mendoza, Jean-François Lebas, Laurent Pelletier, François Berger

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e80056 (2013)

Vessel abnormalities are among the most important features in malignant glioma. Vascular endothelial (VE)-cadherin is of major importance for vascular integrity. Upon cytokine challenge, VE-cadherin structural modifications have been described includ

Externí odkaz: https://doaj.org/article/1c5bc8f9a8524eca9fa79d831dfd711f

An easy method for the determination of active concentrations of cholinesterase reactivators in blood samples: Application to the efficacy assessment of non quaternary reactivators compared to HI-6 and pralidoxime in VX-poisoned mice

Autor: Guillaume Mercey, José A. Dias, Ludovic Jean, Mélanie Touvrey-Loiodice, Florian Nachon, André-Guilhem Calas, Catherine Rousseau, Pierre-Yves Renard, Mélanie Arboléas

Publikováno v: Chemico-Biological Interactions
Chemico-Biological Interactions, Elsevier, 2017, 267 (1), pp.11-16. ⟨10.1016/j.cbi.2016.03.009⟩

International audience; Organophosphorus nerve agents, like VX, are highly toxic due to their strong inhibition potency against acetylcholinesterase (AChE). AChE inhibited by VX can be reactivated using powerful nucleophilic molecules, most commonly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b480e67326f0d7d8ba71a7a68f209494
https://doi.org/10.1016/j.cbi.2016.03.009

Targeting CD44 receptor-positive lung tumors using polysaccharide-based nanocarriers: Influence of nanoparticle size and administration route

Autor: Christophe Schatz, Amandine Hurbin, Jonathan Lavaud, Laetitia Vanwonterghem, Sébastien Lecommandoux, Silvia Mazzaferro, Mélanie Arboléas, Véronique Josserand, Victor Jeannot, Maxime Henry, Jean-Luc Coll, Julien Vollaire

Publikováno v: Nanomedicine: Nanotechnology, Biology and Medicine
Nanomedicine: Nanotechnology, Biology and Medicine, 2016, 12 (4), pp.921-932. ⟨10.1016/j.nano.2015.11.018⟩
Nanomedicine: Nanotechnology, Biology and Medicine, Elsevier, 2016, 12 (4), pp.921-932. ⟨10.1016/j.nano.2015.11.018⟩

International audience; New approaches that are more efficient and able to specifically reach lung tumors are needed. We developed new hyaluronan-based nanoparticles targeting CD44 receptors of two different sizes and compared their lung cancer cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add7a20098e194e0e443dbd2a7429285
https://pubmed.ncbi.nlm.nih.gov/26724540

Phenyltetrahydroisoquinoline-pyridinaldoxime conjugates as efficient uncharged reactivators for the dephosphylation of inhibited human acetylcholinesterase

Autor: Emilie Gillon, Tristan Verdelet, Mélanie Loiodice, Florian Nachon, Ludovic Jean, Maria Kliachyna, Guillaume Mercey, Rachid Baati, Julien Renou, Pierre-Yves Renard, Mélanie Arboléas

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2012, 55 (23), pp.10791-10795. ⟨10.1021/jm3015519⟩

International audience; Pyridinium and bis-pyridinium aldoximes are used as antidotes to reactivate acetylcholinesterase (AChE) inhibited by organophosphorus nerve agents. Herein, we described a series of nine nonquaternary phenyltetrahydroisoquinoli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297989f0230722f691d4234226e6de19
https://hal.archives-ouvertes.fr/hal-00996512