Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Mélanie A C Ikeh"'
Autor:
Marienela Y Heredia, Mélanie A C Ikeh, Deepika Gunasekaran, Karen A Conrad, Sviatlana Filimonava, Dawn H Marotta, Clarissa J Nobile, Jason M Rauceo
Publikováno v:
PLoS Genetics, Vol 16, Iss 7, p e1008908 (2020)
The human fungal pathogen Candida albicans is constantly exposed to environmental challenges impacting the cell wall. Signaling pathways coordinate stress adaptation and are essential for commensalism and virulence. The transcription factors Sko1, Ca
Externí odkaz:
https://doaj.org/article/b3dc606061cc4324a278f8362bdbb4ef
Autor:
Alison M Day, Deborah A Smith, Mélanie A C Ikeh, Mohammed Haider, Carmen M Herrero-de-Dios, Alistair J P Brown, Brian A Morgan, Lars P Erwig, Donna M MacCallum, Janet Quinn
Publikováno v:
PLoS Pathogens, Vol 13, Iss 1, p e1006131 (2017)
The Ypd1 phosphorelay protein is a central constituent of fungal two-component signal transduction pathways. Inhibition of Ypd1 in Saccharomyces cerevisiae and Cryptococcus neoformans is lethal due to the sustained activation of the 'p38-related' Hog
Externí odkaz:
https://doaj.org/article/8363b7374d17493281fa75d5ffc25161
Autor:
Yasmin Ahmed, Mélanie A. C. Ikeh, Donna M. MacCallum, Alison M. Day, Kevin Waldron, Janet Quinn
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT The ability of pathogenic fungi to obtain essential nutrients from the host is vital for virulence. In Candida albicans, acquisition of the macronutrient phosphate is regulated by the Pho4 transcription factor and is important for both virul
Externí odkaz:
https://doaj.org/article/705e6bf7868e48a98baa465733475fa2
Publikováno v:
mSphere, Vol 5, Iss 6 (2020)
mSphere
mSphere, vol 5, iss 6
mSphere
mSphere, vol 5, iss 6
Candida albicans is one of the most common pathogens of humans. One important virulence factor of C. albicans is its ability to form elongated hyphae that can invade host tissues and cause disseminated infections. Here, we show the effect of differen
Autor:
Jason M. Rauceo, Deepika Gunasekaran, Clarissa J. Nobile, Mélanie A. C. Ikeh, Marienela Y. Heredia
Publikováno v:
Curr Genet
Current genetics, vol 66, iss 6
Current genetics, vol 66, iss 6
The human fungal pathogen Candida albicans maintains pathogenic and commensal states primarily through cell wall functions. The echinocandin antifungal drug caspofungin inhibits cell wall synthesis and is widely used in treating disseminated candidia
Autor:
Yulong Zhang, Jun Wu, Jiao Gong, Mélanie A. C. Ikeh, Jian Bing, Clarissa J. Nobile, Li Tao, Guanghua Huang
Publikováno v:
Antimicrobial agents and chemotherapy, vol 64, iss 1
Mammalian serum amyloid A (SAA) is a major acute phase protein that shows a massive increase in plasma concentration during inflammation. In the present study, we demonstrate that the expression of mouse SAA1 in serum was increased when infected with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90178f08f85aa3a0c63030d4a33629ad
https://escholarship.org/uc/item/7d00j0tt
https://escholarship.org/uc/item/7d00j0tt
Autor:
Sviatlana Filimonava, Deepika Gunasekaran, Marienela Y. Heredia, Mélanie A. C. Ikeh, Jason M. Rauceo, Karen A. Conrad, Dawn H. Marotta, Clarissa J. Nobile
Publikováno v:
PLoS Genetics, Vol 16, Iss 7, p e1008908 (2020)
PLoS Genetics
PLoS Genetics
The human fungal pathogen Candida albicans is constantly exposed to environmental challenges impacting the cell wall. Signaling pathways coordinate stress adaptation and are essential for commensalism and virulence. The transcription factors Sko1, Ca
Publikováno v:
Biophysical Journal. 118:619a
Publikováno v:
Infection and Immunity. 86
Polymicrobial intra-abdominal infections (IAIs) are a significant cause of morbidity and mortality, particularly when fungal pathogens are involved. Our experimental murine model of IAI involving intraperitoneal inoculation of Candida albicans and St
Polymicrobial intra-abdominal infections (IAI) involving Candida albicans and Staphylococcus aureus are associated with severe morbidity and mortality (∼80%). Our laboratory discovered that the immunomodulatory eicosanoid prostaglandin E 2 (PGE 2 )
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9971886dd2c1203c754077f411fe0993
https://europepmc.org/articles/PMC5826135/
https://europepmc.org/articles/PMC5826135/