Effect of Metformin on T2D-Induced MAM Ca2+ Uncoupling and Contractile Dysfunction in an Early Mouse Model of Diabetic HFpEF

Autor: Mélanie Paillard, MAYA DIA, Stéphanie Chanon, Helene Thibault, Nadia BENDRIDI, Jennifer Rieusset, Christelle Leon, Team2 Carmen, Ludovic Gomez, Carmen Lab, Team3 Carmen

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2022, 23 (7), pp.3569. ⟨10.3390/ijms23073569⟩

International audience; Diabetic cardiomyopathy (DCM) is a leading complication in type 2 diabetes patients. Recently, we have shown that the reticulum-mitochondria Ca2+ uncoupling is an early and reversible trigger of the cardiac dysfunction in a di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78be34a423cb8ac5a5c13af9f28d3c38
https://hal.inrae.fr/hal-03651077

Abstract 3563: Postconditioning Inhibits Mitochondrial Permeability Transition Pore Opening Independently of any Modification of the Oxidative Phosphorylation and of the Inner Membrane Potential at Reperfusion

Autor: Mélanie Paillard, Ludovic Gomez, Lionel Augeul, Joseph Loufouat, Michel Ovize

Publikováno v: Circulation. 118

Mitochondrial permeability transition pore (mPTP) inhibition plays a crucial role in postconditioning (PostC). We sought to determine whether oxidative phosphorylation and mitochondrial membrane potential (ΔΨ m ), which both modulate mPTP opening,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d438f6e0df4944b3053653f8b9538357
https://doi.org/10.1161/circ.118.suppl_18.s_445-a