Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Méabh B. Brennan"'
Autor:
James A. Lee, Alice M. R. Kennett, Ai M. Fletcher, Marta Brambilla, Paul M. Roberts, James E. Thomson, Stephen G. Davies, Méabh B. Brennan, Kristína Csatayová, Angela J. Russell
Publikováno v:
The Journal of Organic Chemistry. 82:10297-10309
The diastereoselectivities and rates of epoxidation (upon treatment with Cl3CCO2H then m-CPBA) of a range of cis- and trans-4-aminocycloalk-2-en-1-ol derivatives (containing five-, six-, and seven-membered rings) have been investigated. In all cases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa0c43a0d40e06c81a09290b42d579eb
https://doi.org/10.1021/acs.joc.7b01774
https://doi.org/10.1021/acs.joc.7b01774
Publikováno v:
Journal of Chemical Crystallography. 45:401-409
2-Azido-4-aminocyclohexane-1,3-diols 12, 14 and 16 were synthesised and their crystal structures were studied by X-ray diffraction. Compound 12 crystallizes in the monoclinic space group P2 1 /n with cell parameters of a = 13.7059(2) A, b = 10.8861(2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::809491588bae3d8177b57d9baf21951c
https://doi.org/10.1007/s10870-015-0607-x
https://doi.org/10.1007/s10870-015-0607-x
Autor:
Kristína Csatayová, William D. Green, Stephen G. Davies, James A. Lee, James E. Thomson, Ai M. Fletcher, Méabh B. Brennan, Paul M. Roberts, Angela J. Russell
Publikováno v:
The Journal of Organic Chemistry. 80:6609-6618
Diastereoselective syntheses of dihydroconduramines (±)-B-1, (±)-E-1, and (±)-F-1 have been achieved from N-protected 4-aminocyclohex-2-en-1-ols via two complementary procedures for epoxidation as the key step. Treatment of either trans- or cis-4-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a4f5ef7363daa0650ec746f1778b9b
https://doi.org/10.1021/acs.joc.5b00716
https://doi.org/10.1021/acs.joc.5b00716
Autor:
Carole J. R. Bataille, Matthew J. Durbin, Angela J. Russell, Anna Nadali, Méabh B. Brennan, Robert Westwood, Stefan Knapp, Oleg Fedorov, Roderick G. Walker, Kilian Huber, Graham Michael Wynne, Stephen G. Davies, Alan M. Jones, Gu Liu, Camilo E. Quevedo, Simon Byrne
The PIM family of serine/threonine kinases have become an attractive target for anti-cancer drug development, particularly for certain hematological malignancies. Here, we describe the discovery of a series of inhibitors of the PIM kinase family usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dbafee2ae06cfe33f43c280c5e18964
https://ora.ox.ac.uk/objects/uuid:7b0cdcdc-22cb-46f9-9a3a-f3e33a8b468d
https://ora.ox.ac.uk/objects/uuid:7b0cdcdc-22cb-46f9-9a3a-f3e33a8b468d
Autor:
Martin C. Henstridge, Ai M. Fletcher, David S. Hewings, James A. Lee, Paul M. Roberts, Richard G. Compton, Timothy D. W. Claridge, James E. Thomson, Wataru Kurosawa, Méabh B. Brennan, Stephen G. Davies, Anne K. Schoonen
Publikováno v:
The Journal of organic chemistry. 77(17)
The ammonium-directed olefinic epoxidations of a range of differentially N-substituted cyclic allylic and homoallylic amines (derived from cyclopentene, cyclohexene, and cycloheptene) have been investigated, and the reaction kinetics have been analyz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39520e2684d0baf8729b6e122dc6fe41
http://ora.ox.ac.uk/objects/uuid:35642dd6-bc69-4203-9ac9-ace35e5d1b1f
http://ora.ox.ac.uk/objects/uuid:35642dd6-bc69-4203-9ac9-ace35e5d1b1f
Autor:
Paul M. Roberts, James A. Lee, Stephen G. Davies, Angela J. Russell, Méabh B. Brennan, Ai M. Fletcher, James E. Thomson
Publikováno v:
Australian Journal of Chemistry. 68:610
N-Substituted trans-4-aminocyclohex-2-en-1-ols undergo epoxidation upon treatment with Cl3CCO2H followed by meta-chloroperbenzoic acid (m-CPBA) via competitive pathways resulting from hydrogen-bonding delivery by both the hydroxy group and the in sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9018490a387336ce7ed150aad596225a
https://doi.org/10.1071/ch14531
https://doi.org/10.1071/ch14531