Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mátyás Pajkos"'
Autor:
Tamás Szaniszló, Máté Fülöp, Mátyás Pajkos, Gábor Erdős, Réka Ágnes Kovács, Henrietta Vadászi, József Kardos, Zsuzsanna Dosztányi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Dynein light chain LC8 is a small dimeric hub protein that recognizes its partners through short linear motifs and is commonly assumed to drive their dimerization. It has more than 100 known binding partners involved in a wide range of cellu
Externí odkaz:
https://doaj.org/article/49d83ae47f5e4b64ab62ad0cf6eb3be4
The Origin of Discrepancies between Predictions and Annotations in Intrinsically Disordered Proteins
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1442 (2023)
Disorder prediction methods that can discriminate between ordered and disordered regions have contributed fundamentally to our understanding of the properties and prevalence of intrinsically disordered proteins (IDPs) in proteomes as well as their fu
Externí odkaz:
https://doaj.org/article/51cbffcf289941769fb068a1cf1fc15f
Publikováno v:
Biomolecules, Vol 10, Iss 8, p 1115 (2020)
Cancer is a heterogeneous genetic disease that alters the proper functioning of proteins involved in key regulatory processes such as cell cycle, DNA repair, survival, or apoptosis. Mutations often accumulate in hot-spots regions, highlighting critic
Externí odkaz:
https://doaj.org/article/a800e83f2a8f4e39bce9c5042e7a7885
Autor:
Gábor Erdős, Tamás Szaniszló, Mátyás Pajkos, Borbála Hajdu-Soltész, Bence Kiss, Gábor Pál, László Nyitray, Zsuzsanna Dosztányi
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 12, p e1005885 (2017)
Protein-protein interactions (PPIs) formed between short linear motifs and globular domains play important roles in many regulatory and signaling processes but are highly underrepresented in current protein-protein interaction databases. These types
Externí odkaz:
https://doaj.org/article/9f72bfccb1c34b449303a0b6a11bca49
Publikováno v:
Protein Science. 32
Intrinsically disordered proteins (IDPs) play important roles in a wide range of biological processes and have been associated with various diseases, including cancer. In the last few years, cancer genome projects have systematically collected geneti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d178dfafdba9007999c509587cec47
https://doi.org/10.1002/pro.4522
https://doi.org/10.1002/pro.4522
Autor:
Elizabeth Martínez-Pérez, Mátyás Pajkos, Silvio C.E. Tosatto, Toby J. Gibson, Zsuzsanna Dosztanyi, Cristina Marino-Buslje
BackgroundDisProt is the primary repository of Intrinsically Disordered Proteins. This database is manually curated and the annotations there have strong experimental support. Currently DisProt contains a relatively small number of proteins highlight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f17e53bf9fef6ef6c132b5596eed6818
https://doi.org/10.1101/2022.11.08.515674
https://doi.org/10.1101/2022.11.08.515674
Publikováno v:
Nucleic Acids Research
Intrinsically disordered proteins and protein regions (IDPs/IDRs) exist without a single well-defined conformation. They carry out important biological functions with multifaceted roles which is also reflected in their evolutionary behavior. Computat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b95440339007e82af5a0664967e389
https://pubmed.ncbi.nlm.nih.gov/34048569
https://pubmed.ncbi.nlm.nih.gov/34048569
Autor:
Boglarka Zambo, Evelina Edelweiss, Bastien Morlet, Luc Negroni, Matyas Pajkos, Zsuzsanna Dosztanyi, Soren Ostergaard, Gilles Trave, Jocelyn Laporte, Gergo Gogl
Publikováno v:
eLife, Vol 13 (2024)
Truncation of the protein-protein interaction SH3 domain of the membrane remodeling Bridging Integrator 1 (BIN1, Amphiphysin 2) protein leads to centronuclear myopathy. Here, we assessed the impact of a set of naturally observed, previously uncharact
Externí odkaz:
https://doaj.org/article/f5c33ef1efd744989b95c329d4a4ad45
Autor:
Zsuzsanna Dosztányi, Mátyás Pajkos
Publikováno v:
Progress in Molecular Biology and Translational Science ISBN: 9780323852999
Protein sequences are the result of an evolutionary process that involves the balancing act of experimenting with novel mutations and selecting out those that have an undesirable functional outcome. In the case of globular proteins, the function reli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11b6d5bb9337c0e475df029fb8cd14f8
https://doi.org/10.1016/bs.pmbts.2021.06.017
https://doi.org/10.1016/bs.pmbts.2021.06.017
Publikováno v:
Biomolecules
Volume 10
Issue 8
Biomolecules, Vol 10, Iss 1115, p 1115 (2020)
Volume 10
Issue 8
Biomolecules, Vol 10, Iss 1115, p 1115 (2020)
Cancer is a heterogeneous genetic disease that alters the proper functioning of proteins involved in key regulatory processes such as cell cycle, DNA repair, survival or apoptosis. Mutations often accumulate in hot-spots regions, highlighting critica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cb3405e985e6fb1c4f66875d9f93d60
https://doi.org/10.3390/biom10081115
https://doi.org/10.3390/biom10081115