Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Máté Gyimesi"'
Autor:
Gábor M. Harami, János Pálinkás, Yeonee Seol, Zoltán J. Kovács, Máté Gyimesi, Hajnalka Harami-Papp, Keir C. Neuman, Mihály Kovács
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Human Bloom’s syndrome (BLM) helicase has a role in DNA repair, and BLM deficiency in humans is associated with chromosomal abnormalities. Here the authors employ solution biophysical assays to show BLM maintains a balance for disruption and stabil
Externí odkaz:
https://doaj.org/article/9573787d49d34870aed73bd8e8268d4c
Autor:
Zsolt Borhegyi, Kinga Oravecz, László Kornya, Sharad Kumar Suthar, Ádám Kiss, Máté Déri, Suman Nag, Jacob L. Krans, Katalin Monostory, Máté Gyimesi, Kamirán Á. Hamow, András Málnási-Csizmadia, Ivan Tomasic, István Lőrincz, Patrick J. Tierney, Anna Á. Rauscher, Mihály Kovács, Pál Szabó
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 376:358-373
Blebbistatin, para-nitroblebbistatin (NBleb), and para-aminoblebbistatin (AmBleb) are highly useful tool compounds as they selectively inhibit the ATPase activity of myosin-2 family proteins. Despite the medical importance of the myosin-2 family as d
Autor:
András Málnási-Csizmadia, Ivan Ivic, Demeter Túrós, Domokos Máthé, Anna Á. Rauscher, Gabriella Pál, Peter Toth, Máté Pénzes, Árpád Dobolyi, Nikolett Hegedűs, Krisztián Szigeti, Parasuraman Padmanabhan, Máté Gyimesi
Publikováno v:
Theranostics
Acute ischemic stroke treatment faces an unresolved obstacle as capillary reperfusion remains insufficient after thrombolysis and thrombectomy causing neuronal damage and poor prognosis. Hypoxia-induced capillary constriction is mediated by actomyosi
Autor:
Domokos Máthé, Ivan Ivic, Anna Á. Rauscher, Peter Toth, András Málnási-Csizmadia, Arpad Doboi, Máté Gyimesi, Máté Pénzes, Demeter Túrós
Publikováno v:
Stroke. 52
Inefficient cerebral reperfusion is a major unresolved problem in ischemic stroke treatment because hypoxia-induced constriction of capillaries remains persistent even after recanalization by thrombolysis or thrombectomy. Capillary constriction is me
Autor:
Demeter Túrós, Mihály Kovács, Csilla Kurdi, Ádám I. Horváth, Máté Pénzes, Máté Gyimesi, András Málnási-Csizmadia
Publikováno v:
Stroke. 52
Post-stroke muscle spasticity affects 37% of stroke survivors and disables self-supporting life management. There is a high unmet medical need for an efficient antispastic drug because current muscle relaxants are often of limited efficacy and cause
Autor:
Máté Gyimesi, Gábor Szegvári, György Hegyi, Miklós Képiró, István Lőrincz, András Málnási-Csizmadia, Boglárka H. Várkuti, Mihály Kovács, Ádám I. Horváth
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Subcellular dynamics of non-muscle myosin 2 (NM2) is crucial for a broad-array of cellular functions. To unveil mechanisms of NM2 pharmacological control, we determined how the dynamics of NM2 diffusion is affected by NM2′s allosteric inhibitors, i
Publikováno v:
Trends in Biochemical Sciences. 43:700-713
Blebbistatin is a widely used inhibitor of myosin 2 that enables the study of a broad range of cytoskeleton-related processes. However, blebbistatin has several limitations hindering its applicability: it is fluorescent, poorly water soluble, cytotox
Publikováno v:
Applied Sciences
Volume 9
Issue 23
Volume 9
Issue 23
Fault Detection and Diagnosis of electrical machine and drive systems are of utmost importance in modern industrial automation. The widespread use of Machine Learning techniques has made it possible to replace traditional motor fault detection techni
Autor:
Jiri Novacek, Mihály Kovács, Lumir Krejci, Máté Gyimesi, Jarmila Mlcouskova, Eszter Molnár, Ondrej Beláň, Mário Špírek, Gábor M. Harami
Publikováno v:
Nucleic Acids Research
Formation of RAD51 filaments on single-stranded DNA is an essential event during homologous recombination, which is required for homology search, strand exchange and protection of replication forks. Formation of nucleoprotein filaments (NF) is requir
Autor:
Mate Winternitz, András Málnási-Csizmadia, Sharad Kumar Suthar, Máté Gyimesi, Anna Á. Rauscher
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 204:114246
Simple and consistent chiral HPLC methods for the efficient separation of enantiomeric blebbistatin derivatives, namely parent compound blebbistatin and derivatives 4-nitroblebbistatin, 4-aminoblebbistatin, 4-dimethylaminoblebbistatin, and 4-t-butylb