Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mário N Laço"'
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e43563 (2012)
Alterations in the ubiquitin-proteasome system (UPS) have been reported in several neurodegenerative disorders characterized by protein misfolding and aggregation, including the polylgutamine diseases. Machado-Joseph disease (MJD) or Spinocerebellar
Externí odkaz:
https://doaj.org/article/953a45f3f77a47878c368799e837f737
Autor:
Carla Lopes, I. Luísa Ferreira, Carina Maranga, Margarida Beatriz, Sandra I. Mota, José Sereno, João Castelhano, Antero Abrunhosa, Francisco Oliveira, Maura De Rosa, Michael Hayden, Mário N. Laço, Cristina Januário, Miguel Castelo Branco, A. Cristina Rego
Publikováno v:
Redox Biology, Vol 56, Iss , Pp 102424- (2022)
Deficits in mitochondrial function and redox deregulation have been attributed to Huntington's disease (HD), a genetic neurodegenerative disorder largely affecting the striatum. However, whether these changes occur in early stages of the disease and
Externí odkaz:
https://doaj.org/article/41a596c6e228444184c1c9a70b5c8a8a
Publikováno v:
Neurochemical Research. 42:1430-1437
Neurodegenerative diseases are considered to be distinct clinical entities, although they share the formation of proteinaceous aggregates and several neuropathological mechanisms. Increasing evidence suggest a possible interaction between proteins th
Autor:
Michael R. Hayden, Mário N. Laço, Gladys L. Caldeira, A. Cristina Rego, Luana Naia, Ana Oliveira, Tatiana R. Rosenstock, Sofia I. Oliveira-Sousa, Catarina Carmo, Catarina R. Oliveira
Publikováno v:
Molecular Neurobiology. 54:5385-5399
Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent lysine deacetylase that regulates longevity and enhances mitochondrial metabolism. Both activation and inhibition of SIRT1 were previously shown to ameliorate neuropathological
Autor:
Sandrine Humbert, Frédéric Saudou, Teresa Cunha-Oliveira, Mário N. Laço, Luana Naia, Tatiana R. Rosenstock, I. Luísa Ferreira, Márcio Ribeiro, Catarina R. Oliveira, Maria J. Ribeiro, Ana I. Duarte, A. Cristina Rego
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Huntington's disease (HD) is an inherited neurodegenerative disease caused by a polyglutamine repeat expansion in the huntingtin protein. Mitochondrial dysfunction associated with energy failure plays an important role in this untreated pathology. In
Autor:
Ana Silva, A. Cristina Rego, Sandra Aparecida de Almeida, Ana I. Duarte, Cristina Januário, Catarina R. Oliveira, Mário N. Laço, Joana Domingues
Publikováno v:
Mitochondrion. 13:801-809
Mitochondrial dysfunction has been implicated in Huntington's disease (HD) pathogenesis. We analyzed the activity of mitochondrial complexes (Cx) I–IV, protein levels of selected Cx subunits and adenine nucleotides in platelet mitochondria from pre
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1822(2):139-149
Machado–Joseph disease (MJD), also known as Spinocerebellar Ataxia type 3, is an inherited dominant autosomal neurodegenerative disorder. An expansion of Cytosine-Adenine-Guanine (CAG) repeats in the ATXN3 gene is translated as an expanded polyglut
Autor:
Sandra Aparecida de Almeida, Teresa Cunha-Oliveira, A. Cristina Rego, Catarina R. Oliveira, Mário N. Laço
Publikováno v:
Neurobiology of Disease, Vol 35, Iss 3, Pp 448-456 (2009)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
3-Nitropropionic acid (3-NP) is an irreversible inhibitor of succinate dehydrogenase that has been used to explore the primary mechanisms of cell death associated with mitochondrial dysfunction and neurodegeneration in Huntington's disease. In this s
Autor:
A. Cristina Rego, Teresa Cunha-Oliveira, Catarina R. Oliveira, Mário N. Laço, Sandra Aparecida de Almeida
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
3-Nitropropionic acid (3-NP), an inhibitor of mitochondrial complex II, leads to metabolic impairment and neurodegeneration. In this study, we investigated the roles of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the dys
Autor:
Sue M. Travis, Sokol V. Todi, Hsiang M. Wen, Mário N. Laço, Henry L. Paulson, Brett J. Winborn
Publikováno v:
The Journal of biological chemistry. 282(40)
Ataxin-3, a deubiquitinating enzyme, is the disease protein in spinocerebellar ataxia type 3, one of many neurodegenerative disorders caused by polyglutamine expansion. Little is known about the cellular regulation of ataxin-3. This is an important i