Zobrazeno 1 - 10
of 323
pro vyhledávání: '"Mário A. Barbosa"'
Autor:
Cláudia Ribeiro-Machado, Susana G. Santos, Inês A. Amaral, Joana Caldeira, Paulo Pereira, Mário A. Barbosa, Carla Cunha
Publikováno v:
npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-12 (2023)
Abstract Intervertebral disc (IVD) degeneration and herniation is a leading cause of disability globally and a large unmet clinical need. No efficient non-surgical therapy is available, and there is an urgency for minimally invasive therapies capable
Externí odkaz:
https://doaj.org/article/d8f4272e1e434cf680137be435dd28c3
Publikováno v:
Materials Today Advances, Vol 15, Iss , Pp 100252- (2022)
Cancer-related immunosuppression is one of the most challenging aspects of cancer therapy, being one of the principal causes of disease relapse. Most recent immunotherapeutic strategies have been at the forefront of therapies to overcome this problem
Externí odkaz:
https://doaj.org/article/a38dba89a3b04ddba59a7f222632c48f
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-9 (2018)
Abstract Lumbar disc herniation (LDH) is highly associated with inflammation in the context of low back pain. Currently, inflammation is associated with adverse symptoms related to the stimulation of nerve fibers that may lead to pain. However, infla
Externí odkaz:
https://doaj.org/article/6bcd4950d1d74ec497cf2f2fea9c5e49
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-33 (2017)
Abstract In recent years, evidence supporting a link between inflammation and neuropsychiatric disorders has been mounting. Autism spectrum disorders (ASD) and schizophrenia share some clinical similarities which we hypothesize might reflect the same
Externí odkaz:
https://doaj.org/article/4fec2906b5714d14a21da5f382796784
Autor:
Ana Henriques Lourenço, Nuno Neves, Cláudia Ribeiro-Machado, Susana R. Sousa, Meriem Lamghari, Cristina C. Barrias, Abel Trigo Cabral, Mário A. Barbosa, Cristina C. Ribeiro
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Strontium (Sr) has been described as having beneficial influence in bone strength and architecture. However, negative systemic effects have been reported on oral administration of Sr ranelate, leading to strict restrictions in clinical appli
Externí odkaz:
https://doaj.org/article/d89b51d6e53e424f8af93ef4f6927665
Autor:
Andreia M. Silva, Maria I. Almeida, José H. Teixeira, André F. Maia, George A. Calin, Mário A. Barbosa, Susana G. Santos
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Orchestration of bone repair processes requires crosstalk between different cell populations, including immune cells and mesenchymal stem/stromal cells (MSC). Extracellular vesicles (EV) as mediators of these interactions remain vastly unexp
Externí odkaz:
https://doaj.org/article/ee1bd1d9864744f281340bc5184ca1d6
Autor:
Marta L. Pinto, Elisabete Rios, Cecília Durães, Ricardo Ribeiro, José C. Machado, Alberto Mantovani, Mário A. Barbosa, Fatima Carneiro, Maria J. Oliveira
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Macrophages are one of the immune populations frequently found in colorectal tumors and high macrophage infiltration has been associated with both better and worst prognosis. Importantly, according to microenvironment stimuli, macrophages may adopt d
Externí odkaz:
https://doaj.org/article/bb3b7982ba06454d8b492b37876784a4
Autor:
Joana R. Ferreira, Graciosa Q. Teixeira, Susana G. Santos, Mário A. Barbosa, Graça Almeida-Porada, Raquel M. Gonçalves
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Mesenchymal stromal cells (MSCs) are self-renewing, culture-expandable adult stem cells that have been isolated from a variety of tissues, and possess multipotent differentiation capacity, immunomodulatory properties, and are relatively non-immunogen
Externí odkaz:
https://doaj.org/article/42ff91bed4174780a337cffb32199d0a
Publikováno v:
Stem Cell Reports, Vol 6, Iss 4, Pp 466-473 (2016)
Strategies for improved homing of mesenchymal stem cells (MSCs) to a place of injury are being sought and it has been shown that natural killer (NK) cells can stimulate MSC recruitment. Here, we studied the chemokines behind this recruitment. Assays
Externí odkaz:
https://doaj.org/article/86abca1b1132414f8304b5398608389b
Autor:
Carla Cunha, Graciosa Q. Teixeira, Cláudia Ribeiro-Machado, Catarina L. Pereira, Joana R. Ferreira, Maria Molinos, Susana G. Santos, Mário A. Barbosa, Raquel M. Goncalves
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1730 (2020)
Inflammation is central in intervertebral disc (IVD) degeneration/regeneration mechanisms, and its balance is crucial to maintain tissue homeostasis. This work investigates the modulation of local and systemic inflammatory response associated with IV
Externí odkaz:
https://doaj.org/article/d66504f7a73b424ea2866daef20425a6