Zobrazeno 1 - 10 of 24 pro vyhledávání: '"Máire F. Quigley"'
1
Akademický článek
Single-cell multiplexed cytokine profiling of CD19 CAR-T cells reveals a diverse landscape of polyfunctional antigen-specific response
Autor: Qiong Xue, Emily Bettini, Patrick Paczkowski, Colin Ng, Alaina Kaiser, Timothy McConnell, Olja Kodrasi, Máire F. Quigley, James Heath, Rong Fan, Sean Mackay, Mark E. Dudley, Sadik H. Kassim, Jing Zhou
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 5, Iss 1, Pp 1-16 (2017)
Abstract Background It remains challenging to characterize the functional attributes of chimeric antigen receptor (CAR)-engineered T cell product targeting CD19 related to potency and immunotoxicity ex vivo, despite promising in vivo efficacy in pati
Externí odkaz: https://doaj.org/article/ad391b0cd0634de0af9c0fb1b8b1b2e4
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2
Akademický článek
Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection.
Autor: Edwin Leeansyah, Jenny Svärd, Joana Dias, Marcus Buggert, Jessica Nyström, Máire F Quigley, Markus Moll, Anders Sönnerborg, Piotr Nowak, Johan K Sandberg
Publikováno v: PLoS Pathogens, Vol 11, Iss 8, p e1005072 (2015)
Mucosa-associated invariant T (MAIT) cells represent a large innate-like evolutionarily conserved antimicrobial T-cell subset in humans. MAIT cells recognize microbial riboflavin metabolites from a range of microbes presented by MR1 molecules. MAIT c
Externí odkaz: https://doaj.org/article/7f527c6195cb4b9397fe48033f417edd
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4
Single-cell multiplexed cytokine profiling of CD19 CAR-T cells reveals a diverse landscape of polyfunctional antigen-specific response
Autor: Jing Zhou, Patrick Paczkowski, Bettini Emily, Mark E. Dudley, Alaina Kaiser, Sean Mackay, Máire F. Quigley, Rong Fan, Qiong Xue, James R. Heath, Colin Ng, Olja Kodrasi, Timothy McConnell, Sadik H. Kassim
Publikováno v: Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 5, Iss 1, Pp 1-16 (2017)
Background It remains challenging to characterize the functional attributes of chimeric antigen receptor (CAR)-engineered T cell product targeting CD19 related to potency and immunotoxicity ex vivo, despite promising in vivo efficacy in patients with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e045fc193dd2f8e6502041aa9c43fb
https://pubmed.ncbi.nlm.nih.gov/29157295
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5
Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection
Autor: Johan K. Sandberg, Ma Somsouk, Steven G. Deeks, Markus Moll, Anupama Ganesh, Barbara L. Shacklett, Máire F. Quigley, Anders Sönnerborg, Jan Andersson, Peter W. Hunt, Edwin Leeansyah, Jeffrey N. Martin
Publikováno v: Blood. 121:1124-1135
Mucosal-associated invariant T (MAIT) cells are an evolutionarily conserved antimicrobial MR1-restricted T-cell subset. MAIT cells are CD161(+), express a V7.2 TCR, are primarily CD8(+) and numerous in blood and mucosal tissues. However, their role i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406799a9441d85d310cea758e3ebb109
https://doi.org/10.1182/blood-2012-07-445429
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6
A human memory T-cell subset with stem cell-like properties
Autor: Nicholas P. Restifo, Luca Gattinoni, Emma Gostick, Ena Wang, David Price, Carl H. June, Yun Ji, Carmine Carpenito, Mario Roederer, Chrystal M. Paulos, Zhiya Yu, Jorge R. Almeida, Zoltan Pos, Daniel C. Douek, Enrico Lugli, Máire F. Quigley, Francesco M. Marincola
Publikováno v: Nature medicine
Immunological memory is thought to depend on a stem cell-like, self-renewing population of lymphocytes capable of differentiating into effector cells in response to antigen re-exposure. Here we describe a long-lived human memory T cell population tha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::475312b4c0ed7ba3495b48edd4f21ebb
http://europepmc.org/articles/PMC3192229
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7
A Mechanism for TCR Sharing between T Cell Subsets and Individuals Revealed by Pyrosequencing
Autor: Jorge R. Almeida, Hui Yee Greenaway, Pauline C. Ng, Daniel C. Douek, Máire F. Quigley, Vanessa Venturi, David Price, Tedi E. Asher, Zachary Ende, Miles P. Davenport, Tina C McIntosh, Samuel Levy
Publikováno v: The Journal of Immunology. 186:4285-4294
The human naive T cell repertoire is the repository of a vast array of TCRs. However, the factors that shape their hierarchical distribution and relationship with the memory repertoire remain poorly understood. In this study, we used polychromatic fl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a107c14f0f06d1aa5749d3143fa8c7d
https://doi.org/10.4049/jimmunol.1003898
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9
IL-10 Restricts Memory T Cell Inflation during Cytomegalovirus Infection
Autor: Maria A. Stacey, Emma Gostick, Ian R. Humphreys, David Price, Morgan Jones, Kristin Ladell, Máire F. Quigley, Katherine K Wynn
Publikováno v: The Journal of Immunology. 185:3583-3592
The β-herpesvirus CMV induces a substantial and progressive expansion of virus-specific memory CD8 T cells, which protect the host against viral reactivation from latency. In this paper, we report that this expansion, or “inflation,” of memory T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a948473e364d58763c782ec89397e877
https://doi.org/10.4049/jimmunol.1001535
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