Výsledky vyhledávání - "Máire C. Timoney"

The Molecular Basis of Celmer's Rules: The Stereochemistry of the Condensation Step in Chain Extension on the Erythromycin Polyketide Synthase

Autor: Ulf Hanefeld, James Staunton, Kira J. Weissman, Peter F. Leadlay, Matthew Bycroft, Peter Grice, Máire C. Timoney

Publikováno v: Biochemistry. 36:13849-13855

Modular polyketide synthases (PKSs), for example, the 6-deoxyerythronolide B synthase (DEBS) responsible for synthesis of the aglycone core of the macrolide antibiotic erythromycin, generate an impressive diversity of asymmetric centers in their poly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ffca678619a97133d4200347d18fc46
https://doi.org/10.1021/bi971566b

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Heterologous expression in Saccharopolyspora erythraea of a pentaketide synthase derived from the spinosyn polyketide synthase

Autor: Christine J, Martin, Máire C, Timoney, Rose M, Sheridan, Steven G, Kendrew, Barrie, Wilkinson, James C, Staunton, Peter F, Leadlay

Publikováno v: Organicbiomolecular chemistry. 1(23)

A truncated version of the spinosyn polyketide synthase comprising the loading module and the first four extension modules fused to the erythromycin thioesterase domain was expressed in Saccharopolyspora erythraea. A novel pentaketide lactone product

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::acb6447db67bd9e2d76fea1da54eb5da
https://pubmed.ncbi.nlm.nih.gov/14685317

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Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues

Autor: Anand Ranganathan, Matthew Bycroft, Ian S. Galloway, Iain P Thomas, Laurenz Kellenberger, Jesus Cortes, Barrie Wilkinson, Ulf Hanefeld, Peter F. Leadlay, Máire C. Timoney, James Staunton

Publikováno v: Chemistrybiology. 6(10)

Background: Polyketides are structurally diverse natural products that have a range of medically useful activities. Nonaromatic bacterial polyketides are synthesised on modular polyketide synthase (PKS) multienzymes, in which each cycle of chain exte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94cdf45ae2e6da33403a9a7af390bc5f
https://pubmed.ncbi.nlm.nih.gov/10508677

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Heterologous expression in Saccharopolyspora erythraea of a pentaketide synthase derived from the spinosyn polyketide synthaseElectronic supplementary information (ESI) available: Further details of the construction of pCJR308, the fermentation of BIOT-0966 and the isolation of pentaketide lactone, 3, and figures showing the13C NMR and 1H COSY spectra of 3. See http://www.rsc.org/suppdata/ob/b3/b310740j

Autor: Barrie Wilkinson, Rose Mary Sheridan, Peter F. Leadlay, Christine Martin, Steven G. Kendrew, Máire C. Timoney, James Staunton

Publikováno v: Organic & Biomolecular Chemistry. 1:4144

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f2167a30e618cf0c94af1d0fc7f4d06
https://doi.org/10.1039/b310740j

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Evaluating precursor-directed biosynthesis towards novel erythromycins through in vitro studies on a bimodular polyketide synthase

Autor: Sandeep Handa, James Staunton, Kira J. Weissman, Peter F. Leadlay, Matthew Bycroft, Ulf Hanefeld, Marc Roddis, Elizabeth J. Frost, Máire C. Timoney, Annabel L. Cutter, Rebecca Harris

Publikováno v: Chemistry & Biology. (12):743-754

Background: Modular polyketide synthases (PKSs) catalyse the biosynthesis of complex polyketides using a different set of enzymes for each successive cycle of chain extension. Directed biosynthesis starting from synthetic diketides is a potentially v

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