Integration and Validation of the Genome-Scale Metabolic Models of Pichia pastoris: A Comprehensive Update of Protein Glycosylation Pathways, Lipid and Energy Metabolism.

Autor: Màrius Tomàs-Gamisans, Pau Ferrer, Joan Albiol

Publikováno v: PLoS ONE, Vol 11, Iss 1, p e0148031 (2016)

MOTIVATION:Genome-scale metabolic models (GEMs) are tools that allow predicting a phenotype from a genotype under certain environmental conditions. GEMs have been developed in the last ten years for a broad range of organisms, and are used for multip

Externí odkaz: https://doaj.org/article/47a8877f95c043be8f4b7e33e56ed77a

Redox Engineering by Ectopic Overexpression of NADH Kinase in Recombinant Pichia pastoris ( Komagataella phaffii ): Impact on Cell Physiology and Recombinant Production of Secreted Proteins

Autor: Francisco Maresca, Màrius Tomàs-Gamisans, Joan Albiol, Cristiane Conte Paim de Andrade, Pau Ferrer, Sergi Monforte

Publikováno v: Applied and Environmental Microbiology. 86

High-level expression and secretion of heterologous proteins in yeast causes an increased energy demand, which may result in altered metabolic flux distributions. Moreover, recombinant protein overproduction often results in ER-stress and oxidative s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f46109331067d1d1ac0c29e646e4162
https://doi.org/10.1128/aem.02038-19

Glycerol metabolism of Pichia pastoris (Komagataella spp.) characterised by

Autor: Màrius, Tomàs-Gamisans, Anders Sebastian Rosenkrans, Ødum, Mhairi, Workman, Pau, Ferrer, Joan, Albiol

Publikováno v: New biotechnology. 50

Metabolic flux analysis based on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::84724230cfed94db3c8b6b5dddd625a2
https://pubmed.ncbi.nlm.nih.gov/30659933

Integration and Validation of the Genome-Scale Metabolic Models of Pichia pastoris: A Comprehensive Update of Protein Glycosylation Pathways, Lipid and Energy Metabolism

Autor: Joan Albiol, Pau Ferrer, Màrius Tomàs-Gamisans

Publikováno v: PLoS ONE, Vol 11, Iss 1, p e0148031 (2016)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
PLoS ONE
Recercat. Dipósit de la Recerca de Catalunya
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Motivation Genome-scale metabolic models (GEMs) are tools that allow predicting a phenotype from a genotype under certain environmental conditions. GEMs have been developed in the last ten years for a broad range of organisms, and are used for multip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::868c95c928991b6cb1645bf1df4f45d0
http://europepmc.org/articles/PMC4734642?pdf=render