B-cell antigen receptor stimulation activates the human Bruton's tyrosine kinase, which is deficient in X-linked agammaglobulinemia

Autor: Ruud K. B. Schuurman, Rudolf W. Hendriks, Gaby S. Brouns, Christine Kinnon, Jannie Borst, S. Hinshelwood, M. De Weers

Publikováno v: Journal of Biological Chemistry. 269:23857-23860

X-linked agammaglobulinemia (XLA) is an inherited human immunodeficiency disease, characterized by an arrest in B-cell development, which results in a dramatic decrease in immunoglobulin production. The gene product defective in XLA has been identifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::716294953e837619f9c1e616182b70f4
https://doi.org/10.1016/s0021-9258(19)51014-6

The therapeutic human CD38 antibody daratumumab improves the anti-myeloma effect of newly emerging multi-drug therapies

Autor: Paul W. H. I. Parren, Shulamiet Wittebol, Joost M. Bakker, H M Lokhorst, M de Weers, Tuna Mutis, M S van der Veer, B van Kessel

Publikováno v: Blood cancer journal, 1(10):e41. Nature Publishing Group
Van Der Veer, M S, De Weers, M, Van Kessel, B, Bakker, J M, Wittebol, S, Parren, P W H I, Lokhorst, H M & Mutis, T 2011, ' The therapeutic human CD38 antibody daratumumab improves the anti-myeloma effect of newly emerging multi-drug therapies ', Blood cancer journal, vol. 1, no. 10, e41 . https://doi.org/10.1038/bcj.2011.42
Blood Cancer Journal

Multiple myeloma (MM) is an incurable malignancy of antibody-producing clonal plasma cells. The mean life expectancy of patients has remained at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362c3343e92cc1c4b33187fcea0b73e7
https://research.vumc.nl/en/publications/c4aa3507-e860-4e03-b425-a07b3deb058f

Expression of Bruton's tyrosine kinase in B lymphoblastoid cell lines from X-linked agammaglobulinaemia patients

Autor: Ruth C. Lovering, Rob G.J. Mensink, Gaby S. Brouns, M. De Weers, Ruud K. B. Schuurman, Margriet E. M. Kraakman, Rudolf W. Hendriks, Jannie Borst, G. M. Dingjan

Publikováno v: Clinical and experimental immunology. 107(2)

SUMMARY X-linked agammaglobulinaemia (XLA) is an immunodeficiency caused by mutations in Bruton's tyrosine kinase (Btk) and is characterized by an almost complete arrest of B cell development. We analysed expression of Btk in B lymphoblastoid cell li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd6569f889b51c140ca0b7fb9ee685e5
https://pubmed.ncbi.nlm.nih.gov/9030858

Mutation analysis of the Bruton's tyrosine kinase gene in X-linked agammaglobulinemia: identification of a mutation which affects the same codon as is altered in immunodeficient xid mice

Autor: Rob G.J. Mensink, M. De Weers, Ruud K. B. Schuurman, Margriet E. M. Kraakman, Rudolf W. Hendriks

Publikováno v: Human molecular genetics. 3(1)

X-linked agammaglobulinemia (XLA) is an inherited immunodeficiency disease in man, reflecting an arrest in differentiation of pre-B cells to mature B cell stages. The gene defective in XLA has been identified as a cytoplasmic protein tyrosine kinase,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d5602aa6722f52aa10544f8f9096c6
https://pubmed.ncbi.nlm.nih.gov/8162018

Mhc-DRB and -DQA1 nucleotide sequences of three lowland gorillas. Implications for the evolution of primate Mhc class II haplotypes

Autor: M, Kenter, N, Otting, M, de Weers, J, Anholts, C, Reiter, M, Jonker, R E, Bontrop

Publikováno v: Human immunology. 36(4)

Mhc-DRB and -DQA1 second-exon and -DRB 3'-untranslated-region nucleotide sequences of three lowland gorillas with no known family relationship with each other and of two HLA homozygous typing cell lines were determined and compared with published pri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c2da86614b65f0874f0627b204061494
https://pubmed.ncbi.nlm.nih.gov/8340229