Zobrazeno 1 - 10 of 125 pro vyhledávání: '"M, Zurini"'
1
Measurement of Cdk4 Kinase Activity Using an Affinity Peptide-Tagging Technology
Autor: J J, Wu, D R, Yarwood, M A, Sills, B, Chaudhuri, L, Muller, M, Zurini
Publikováno v: Combinatorial Chemistry & High Throughput Screening. 3:27-36
Cyclin dependent kinases such as Cdk4 are involved in the control of cell cycle progression, and misregulation of Cdk4 has been implicated in many types of cancers. In the present study, we report the development of a novel homogeneous assay using an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a0861a69513547f266a0a4250de860
https://doi.org/10.2174/1386207003327774
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2
Cyclization reactions of IMM-125 and oxidation of cyclosporin A amino-acid 1 in theαposition of the double bond lead to the loss ofin vitroimmunosuppressive activity
Autor: Nicole Maton, M. Zurini, Reiner Dieden, A. Aubry, D. Latinne, Georges Lhoëst, C Baldari, R. K. Verbeeck
Publikováno v: Scopus-Elsevier
Cyclosporin A (CsA) and IMM-125, a hydroxyethyl derivative of D-serine CsA, are cyclic undecapeptides of molecular weight 1201.8 and 1261.8, respectively. The main metabolites still possessing the undecapeptide structure were found to be compounds re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::132f068cef7676f80ee235a8bf667725
https://doi.org/10.1155/2000/491283
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3
Isolation, identification and immunosuppressive activity of a new IMM-125 metabolite from human liver microsomes. identification of its cyclophilin A-IMM-125 metabolite complex by nanospray tandem mass spectrometry
Autor: A. P. J. M. de Jong, M. Zurini, Dominique Latinne, H. D. Meiring, Roger K. Verbeeck, Georges Lhoëst, J. B. Otte, Nicole Maton
Publikováno v: Journal of Mass Spectrometry. 33:936-942
The isolation from human liver microsomes and identification by electrospray mass spectrometry and tandem mass spectrometry of a new metabolite of IMM-125 resulting from the biotransformation of the amino acid 1 vinylic methyl group to a carboxylic a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::673ac3faa4a4905376ee11000ff6f73e
https://doi.org/10.1002/(sici)1096-9888(1998100)33:10<936::aid-jms702>3.0.co
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4
Leflunomide's Bioactive Metabolite Has the Minimal Structural Requirements for the Efficient Inhibition of Human Dihydroorotate Dehydrogenase
Autor: Christos Papageorgiou, M. Zurini, Hans Peter Weber, Xaver Borer
Publikováno v: Bioorganic Chemistry. 25:233-238
The α-cyano-β-hydroxy enamide 1 is an inhibitor of human dihydroorotate dehydrogenase (IC 50 = 0.26 μM), the rate-limiting enzyme in the de novo pyrimidine biosynthesis. A structure–activity analysis based on selected derivatives of 1 demonstrat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08671e5e1194fb4eeafeb24cd30d1df6
https://doi.org/10.1006/bioo.1997.1072
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5
In vitro and in vivo characterization of a neutral boron-containing thrombin inhibitor
Autor: Rainer Metternich, S R Stone, C Tapparelli, Michael F. Scully, C Ehrhardt, M Zurini, G. Claeson
Publikováno v: Journal of Biological Chemistry. 268:4734-4741
Peptide boronic acid derivatives have proven to be very potent inhibitors of serine proteases with boroarginine derivatives being particularly potent thrombin inhibitors. The importance of the charged side chain of arginine has been investigated by s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f96b4f8eba2118f8eef79a013724214
https://doi.org/10.1016/s0021-9258(18)53458-x
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7
Structure of human cyclophilin and its binding site for cyclosporin A determined by X-ray crystallography and NMR spectroscopy
Autor: Kurt Wüthrich, Malcolm D. Walkinshaw, Jörg Kallen, Gerhard Wider, Mauro G. M. Zurini, Hans Widmer, Claus Spitzfaden
Publikováno v: Nature. 353:276-279
THE protein cyclophilin is the major intracellular receptor for the immunosuppressive drug cyclosporin A (ref. 1). Cyclosporin A acts as an inhibitor of T-cell activation and can prevent graft rejection in organ and bone marrow transplantation2. Cycl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1522689c475e1578239504b1a7fda4c5
https://doi.org/10.1038/353276a0
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8
Configuration of a Simple Dialysis Membrane Bioreactor Suitable for Large-Scale Application
Autor: M. Stenz, B. Straubhaar, B. Kleuser, M. Zurini, K. Memmert, Hans P. Kocher
Publikováno v: Animal Cell Technology: Products from Cells, Cells as Products ISBN: 9780792360759
We have developed a prototype dialysis reactor of 10L working volume, which combines the advantages of batch and of continuous fermentation processes and allows further scalability. Batch fermentations with and without an integrated dialysis membrane
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5273576b0d89aa1a1fc3434971cabde
https://doi.org/10.1007/0-306-46875-1_67
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9
Crystallisation and preliminary X-ray diffraction studies of cyclophilin-tetrapeptide and cyclophilin-cyclosporin complexes
Autor: Johan N. Jansonius, Gaston Pfluegl, Joerg Kallen, Malcolm D. Walkinshaw, Vincent Mikol, Mauro G. M. Zurini
Publikováno v: FEBS Letters. 276:63-66
Recombinant human cyclophilin has been co-crystallised with a number of peptides to give crystals suitable for X-ray analysis. The crystal complexes for which heavy-atom derivatives have been prepared and X-ray data collected are: cyclophilin with N-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9524cbc23ae159e6d6a04d0e7dd81cc9
https://doi.org/10.1016/0014-5793(90)80507-f
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10
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