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Ruxolitinib Cream in the Treatment of Cutaneous Lichen Planus: A Prospective, Open-Label Study

Autor: Caitlin M. Brumfiel, Meera H. Patel, Kevin J. Severson, Nan Zhang, Xing Li, Jaxon K. Quillen, Samantha M. Zunich, Emily L. Branch, Steven A. Nelson, Mark R. Pittelkow, Aaron R. Mangold

Publikováno v: Journal of Investigative Dermatology. 142:2109-2116.e4

Ruxolitinib is a Janus kinase 1/2 inhibitor that blocks signal transduction of interferon-gamma, a critical cytokine involved in the pathogenesis of cutaneous lichen planus (LP). In this prospective phase II study, we investigated the efficacy of top

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a51db6dc8e898318ef058f765a28297f
https://doi.org/10.1016/j.jid.2022.01.015

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Insulin-like growth factor-I enhances the biological activity of brain-derived neurotrophic factor on cerebrocortical neurons

Autor: Keith W. Kelley, Katherine McCrea, Rodney W. Johnson, Robert Dantzer, Robert H. McCusker, Samantha M. Zunich, Suzanne R. Broussard

Publikováno v: Journal of Neuroimmunology. 179:186-190

Insulin-like growth factor (IGF)-I and brain-derived neurotrophic factor (BDNF) act within the brain to enhance neuronal survival and plasticity. We extend these findings by showing that the presence of both neurotrophins is required to depress the r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2cf40f04b1562a3eb70c31cdbff54c
https://doi.org/10.1016/j.jneuroim.2006.06.014

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Mild stretch-induced injury increases susceptibility to interleukin-1β-induced release of matrix metalloproteinase-9 from astrocytes

Autor: Mark S. Wainwright, Hantamalala Ralay Ranaivo, Samantha M. Zunich, Nicole Choi, Jessica N. Hodge

Publikováno v: Journal of neurotrauma. 28(9)

Traumatic brain injury (TBI) results in the activation of glia and the release of proinflammatory cytokines, including interleukin (IL)-1β. The response of astrocytes to mild TBI has not been well studied. We used an in vitro model of cell stretch t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9658ea330a7a7060a6162aebafd006cd
https://pubmed.ncbi.nlm.nih.gov/21732764

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Paracrine sonic hedgehog signalling by prostate cancer cells induces osteoblast differentiation

Autor: Samantha M. Zunich, Taneka Douglas, Tiffany Chang, Maria Valdovinos, Wade Bushman, David O. Walterhouse, Marilyn L. G. Lamm, Philip M. Iannaccone

Publikováno v: Molecular Cancer, Vol 8, Iss 1, p 12 (2009)
Molecular Cancer

Background Sonic hedgehog (Shh) and components of its signalling pathway have been identified in human prostate carcinoma and increased levels of their expression appear to correlate with disease progression and metastasis. The mechanism through whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a287b7a241e45eb64501cd21cc3fbbc6
http://www.molecular-cancer.com/content/8/1/12

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A Phase I/II Trial of Zidovudine, Interferon- , and Granulocyte-Macrophage Colony-Stimulating Factor in the Treatment of Human Immunodeficiency Virus Type 1 Infection

Autor: John Zurlo, Kathryn M. Zunich, Victoria J. Davey, Michael A. Polis, Julia A. Metcalf, H. Clifford Lane, Judith Falloon, Henry Masur, Joseph A. Kovacs, Richard T. Davey

Publikováno v: Journal of Infectious Diseases. 164:43-52

Twenty-four patients infected with human immunodeficiency virus type 1 (HIV-1) who had CD4+ counts of 0.2-0.5 x 10(9) cells/l received granulocyte-macrophage colony-stimulating factor (GM-CSF) in combination with zidovudine plus escalating doses of d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::762c1ad3beb371f8ca126cb8ae69775b
https://doi.org/10.1093/infdis/164.1.43

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Immunologic Abnormalities in HIV Infection

Autor: H. C. Lane, K. M. Zunich

Publikováno v: Hematology/Oncology Clinics of North America. 5:215-228

A variety of immunologic abnormalities have been reported in human immunodeficiency virus (HIV) infection, the most characteristic being a progressive decline in the number and function of circulating CD4 + T lymphocytes. Other defects in the immune

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::524e1fe0e805a067120b466a652fb9ba
https://doi.org/10.1016/s0889-8588(18)30437-4

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Prototypical anti-inflammatory cytokine IL-10 prevents loss of IGF-I-induced myogenin protein expression caused by IL-1beta

Autor: Robert H. McCusker, Keith W. Kelley, Robert Dantzer, Rodney W. Johnson, Klemen Strle, Samantha M. Zunich

Publikováno v: American journal of physiology. Endocrinology and metabolism. 294(4)

Prolonged and excessive inflammation is implicated in resistance to the biological actions of IGF-I and contributes to the pathophysiology of neurodegenerative, metabolic, and muscle-wasting disorders. IL-10 is a critical anti-inflammatory cytokine t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::840d908022111da8e8bbc78a174107d9
https://pubmed.ncbi.nlm.nih.gov/18270299

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