Zobrazeno 1 - 10
of 37
pro vyhledávání: '"M, Yhap"'
Publikováno v:
Advances in experimental medicine and biology. 457
New analogues of DNA directed chemotherapy moieties are available for comparative efficacy testing in human neoplastic disease. In addition to MTT testing direct assessment of DNA excision repair activity after direct exposure of marrow cells may pro
Publikováno v:
Advances in experimental medicine and biology. 457
Genomic instability may, especially with DNA directed treatment, be associated with increased therapeutic response; absence may be associated with drug resistance. In childhood MNHL, drug response is variable. At present the degree of presence of mic
Autor:
L M, Ball, C L, Lannon, M, Yhap, A F, Pyesmany, M, Henry, K, Laybolt, D C, Riddell, D, van Velzen
Publikováno v:
Advances in experimental medicine and biology. 457
Drug resistance to DNA directed therapy may depend on proliferative as well as apoptotic cell fraction. PCNA/Ki67 ratio excess, possibly reflecting DNA excision repair, is of additional interest to drug resistance in MTT testing. The cell cycle phase
Publikováno v:
Advances in experimental medicine and biology. 457
Apoptotic cell fraction and presence or degree of aneuploidy may both affect treatment outcome in childhood acute lymphoblastic leukaemia (ALL), which is largely defined by drug resistance. Independence of the variables is at present not established.
Publikováno v:
Advances in experimental medicine and biology. 457
Treatment response/drug resistance in childhood acute lymphoblastic leukaemia (ALL) is related to presenting white cell count. This relationship might be explained by high proliferation fraction or by absence of significant apoptosis, but is presentl
Publikováno v:
Advances in experimental medicine and biology. 457
Assessment of resistance to drug moieties in tissue culture is complicated by limited sample, clonal selection and alteration of cycling fraction and cycle duration in clonally mixed lesions. DNA damage assessment by single cell gel electrophoresis (
Publikováno v:
Advances in experimental medicine and biology. 457
High resolution Confocal Laser Scanning Microscopy (CLSM) may be applied to testing of drug resistance in vitro in clinical setting. Rapid analysis of DNA damage by precise quantitation of excised DNA in bone marrow samples exposed to potential treat
Autor:
L M, Ball, A F, Pyesmany, M, Yhap, C L, Lannon, M, Henry, K, Laybolt, D C, Riddell, D, van Velzen
Publikováno v:
Advances in experimental medicine and biology. 457
Tumour doubling time, a parameter in drug sensitivity testing, reflects both cell proliferation and apoptosis. Variable apoptosis fractions may explain the poor correlation of S-fraction and drug response. DNA aneuploidy (reflecting intrinsic DNA ins
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Akademický článek
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