Zobrazeno 1 - 10
of 962
pro vyhledávání: '"M, Wunderlich"'
Autor:
Lennart Höfs, David Geißler-Lösch, Kristof M. Wunderlich, Eva M. Szegö, Chris Van den Haute, Veerle Baekelandt, Wolfgang Hoyer, Björn H. Falkenburger
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 756 (2024)
Aggregation of the protein α-Synuclein (αSyn) is a hallmark of Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple systems atrophy, and alleviating the extent of αSyn pathology is an attractive strategy against neurodegenerati
Externí odkaz:
https://doaj.org/article/56e384f27b224c169fcf2c4f39ceedc3
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Treatment of chronic lower back pain (CLBP) should be stratified for best medical and economic outcome. To improve the targeting of potential participants for exclusive therapy offers from payers, Freytag et al. developed a tool to classify
Externí odkaz:
https://doaj.org/article/80be10e38c4341b787783df447f31d1d
Publikováno v:
BMC Musculoskeletal Disorders, Vol 23, Iss 1, Pp 1-18 (2022)
Abstract Background Nonspecific chronic low back pain (CLBP) is a complex symptom with numerous possible causes and influencing factors. Understanding how modifiable factors affect the course of CLBP is important for preventing progression. As the CO
Externí odkaz:
https://doaj.org/article/634ba71315174463a00509e1fff82ef5
Autor:
Camila F. de Souza, Larissa Rugila S. Stopa, Andressa B. Martins, Ana Luiza M. Wunderlich, Gabriela Mendicelli Lopes, Flaviane de Fatima Silva, Ayumi Cristina Medeiros Komino, Dimas A. M. Zaia, Cassia Thaïs B. V. Zaia, Fabio Bessa Lima, Ernane Torres Uchoa
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Introduction: Lactation overnutrition is a programming agent of energy metabolism, and litter size reduction leads to the early development of obesity, which persists until adulthood. Liver metabolism is disrupted by obesity, and increased levels of
Externí odkaz:
https://doaj.org/article/03a3df945a3941eca5b8195c4da3aa3b
Autor:
R. C. Nayak, K. H. Chang, A. K. Singh, M. Kotliar, M. Desai, A. M. Wellendorf, M. Wunderlich, J. Bartram, B. Mizukawa, M. Cuadrado, P. Dexheimer, A. Barski, X. R. Bustelo, N. N. Nassar, J. A. Cancelas
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Ph+ and Ph-like B-ALL remain poor prognosis leukemias. VAV3, a guanine nucleotide exchange factor, is activated and overexpressed in these leukemias. Here the authors reveal that leukemic VAV3 is predominantly nuclear. Nuclear VAV3, through its guani
Externí odkaz:
https://doaj.org/article/986c9d722e04481799558dc5c6550d69
Publikováno v:
BMC Health Services Research, Vol 21, Iss 1, Pp 1-20 (2021)
Abstract Background Multidisciplinary biopsychosocial rehabilitation (MBR) is highly recommended for chronic lower back pain (CLBP) treatment, but its economic benefit remains to be clearly demonstrated. The purpose of this study is to analyse the ef
Externí odkaz:
https://doaj.org/article/4cd9d04cdb974036b494a1f5269ef719
Publikováno v:
BMC Health Services Research, Vol 19, Iss 1, Pp 1-13 (2019)
Abstract Background To facilitate access to evidence-based care for back pain, a German private medical insurance offered a health program proactively to their members. Feasibility and long-term efficacy of this approach were evaluated. Methods Using
Externí odkaz:
https://doaj.org/article/94afc597f7c84bc4b6d254d1c1c9ed40
Publikováno v:
International Soil and Water Conservation Research, Vol 6, Iss 4, Pp 331-339 (2018)
Globally, attention has been drawn to the increasingly alarming rates of food loss and waste (FLW) along the food supply chain (FSC) and its contributions to the depletion of the natural resources and rise in greenhouse gas emissions. Within the past
Externí odkaz:
https://doaj.org/article/1befc4ecfbe348d8961ef76e641ffc6a
Autor:
Melanie J. Mittenbühler, Hans-Georg Sprenger, Sabine Gruber, Claudia M. Wunderlich, Lara Kern, Jens C. Brüning, F. Thomas Wunderlich
Publikováno v:
Molecular Metabolism, Vol 17, Iss , Pp 122-133 (2018)
Objective: The current obesity pandemic represents a major health burden, given that it predisposes to the development of numerous obesity-associated disorders. The obesity-derived adipokines not only impair systemic insulin action but also increase
Externí odkaz:
https://doaj.org/article/774ace42901d46259223257b2842c3ed
Autor:
Heiko Löhr, Simon Hess, Mafalda M.A. Pereira, Philip Reinoß, Sandra Leibold, Christel Schenkel, Claudia M. Wunderlich, Peter Kloppenburg, Jens C. Brüning, Matthias Hammerschmidt
Publikováno v:
Cell Reports, Vol 23, Iss 6, Pp 1728-1741 (2018)
Summary: Anorexigenic pro-opiomelanocortin (Pomc)/alpha-melanocyte stimulating hormone (αMSH) neurons of the hypothalamic melanocortin system function as key regulators of energy homeostasis, also controlling somatic growth across different species.
Externí odkaz:
https://doaj.org/article/546212ab9c514f11989028ecbac57074