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Retour d’expérience des attentats du 13 novembre 2015. Prise en charge psychologique hospitalière des impliqués

Autor: M. Wohl, D. Cantin, N. Dantchev, S. Ben Younes, R. Wallaert, J. Mullner

Publikováno v: Annales françaises de médecine d'urgence. 6:55-61

Lors des attentats du 13 novembre 2015 a Paris, un dispositif de prise en charge hospitaliere des impliques a ete mis en place a l’hopital Hotel-Dieu, complementaire a celui qui a ete assure par les cellules d’urgence medicopsychologique (CUMP).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd405b4bbb5c81fd3728000449ef4e8f
https://doi.org/10.1007/s13341-016-0604-5

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Macromolecular (pro)drugs with concurrent direct activity against the hepatitis C virus and inflammation

Autor: Bettina E. B. Jensen, Alexander N. Zelikin, Benjamin M. Wohl, Anton A. A. Smith

Publikováno v: Wohl, B, Smith, A A A, Jensen, B E B & Zelikin, A N 2014, ' Macromolecular (pro)drugs with concurrent direct activity against the hepatitis C virus and inflammation ', Journal of Controlled Release, vol. 196, pp. 197–207 . https://doi.org/10.1016/j.jconrel.2014.09.032

Macromolecular prodrugs (MPs) are a powerful tool to alleviate side-effects and improve the efficacy of the broad-spectrum antiviral agent ribavirin. In this work, we sought an understanding of what makes an optimal formulation within the macromolecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbcd40167316281ff32b5696633edfd6
https://doi.org/10.1016/j.jconrel.2014.09.032

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Highly Active Macromolecular Prodrugs Inhibit Expression of the Hepatitis C Virus Genome in the Host Cells

Autor: Benjamin M. Wohl, Kaja Zuwala, Jesper Melchjorsen, Anton A. A. Smith, Alexander N. Zelikin, Martin Tolstrup, Pau Ruiz-Sanchis

Publikováno v: Ruiz-Sanchis, P, Wohl, B M, Smith, A A A, Zuwala, K, Melchjorsen, J, Tolstrup, M & Zelikin, A N 2015, ' Highly active macromolecular prodrugs inhibit expression of the hepatitis c virus genome in the host cells ', Advanced Healthcare Materials, vol. 4, no. 1, pp. 65-68 . https://doi.org/10.1002/adhm.201400307

Efficacious, potent, and at the same time nontoxic macromolecular prodrugs of ribavirin are designed taking advantage over prodrug activation by the intracellular milieu. Activity of these prodrugs is illustrated in the cells hosting hepatitis C viru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b75269334e182b85acd609baf8af2ea
https://doi.org/10.1002/adhm.201400307

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Macromolecular (pro)drugs in antiviral research

Autor: Mille B. L. Kryger, Anton A. A. Smith, Alexander N. Zelikin, Martin Tolstrup, Benjamin M. Wohl, Kaja Zuwala, Pau Ruiz-Sanchis

Publikováno v: Smith, A A A, Kryger, M, Wohl, B, Ruiz Sanchis, P, Zuwala, K, Tolstrup, M & Zelikin, A N 2014, ' Macromolecular (pro)Drugs in antiviral research ', Polymer Chemistry, vol. 5, no. 22, pp. 6407-6425 . https://doi.org/10.1039/C4PY00624K

Macromolecular (pro)drugs are a sub-discipline of medicinal and polymer chemistries aiming to optimize the delivery of drugs to their site of action. In recent decades, this field of science has undergone a tremendous development, with the soundest a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c4fee3fee3b02e21a96835439800c8c
https://doi.org/10.1039/c4py00624k

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Macromolecular Prodrugs of Ribavirin: Concerted Efforts of the Carrier and the Drug

Autor: Mille B. L. Kryger, Almar Postma, Benjamin M. Wohl, Natasha Hedemann, Carlos Guerrero-Sanchez, Anton A. A. Smith, Alexander N. Zelikin

Publikováno v: Smith, A A A, Wohl, B M, Kryger, M B L, Hedemann, N, Guerrero-Sanchez, C, Postma, A & Zelikin, A N 2014, ' Macromolecular Prodrugs of Ribavirin: Concerted Efforts of the Carrier and the Drug ', Advanced Healthcare Materials, vol. 3, no. 9, pp. 1404-1407 . https://doi.org/10.1002/adhm.201300637

Polymers in tune. Automated parallel polymer synthesis is developed to obtain libraries of macromolecular prodrugs of ribavirin, a broad-spectrum antiviral agent. As many as 10 identified lead polymer conjugates exhibit therapeutic efficacy matching

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0682ffdc6440bf5840b965226ad093e8
https://doi.org/10.1002/adhm.201300637

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Macromolecular Prodrugs for Controlled Delivery of Ribavirin

Autor: Anton A. A. Smith, Benjamin M. Wohl, Mille B. L. Kryger, Alexander N. Zelikin

Publikováno v: Macromolecular Bioscience. 14:173-185

Ribavirin (RBV)-containing polymers are synthesized based on poly(N-vinylpyrrolidone) and poly(acrylic acid), two polymers with extensive characterization in biomedicine. The copolymers are shown to exhibit a minor to negligible degree of association

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a072adcf398cfcd1986aa8c593793f9
https://doi.org/10.1002/mabi.201300244

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