Zobrazeno 1 - 10
of 383
pro vyhledávání: '"M, Whitley"'
Autor:
Lauren S. Kelly, Jennifer A. Munley, Erick E. Pons, Kolenkode B. Kannan, Elizabeth M. Whitley, Letitia E. Bible, Philip A. Efron, Alicia M. Mohr
Publikováno v:
Animal Models and Experimental Medicine, Vol 7, Iss 3, Pp 367-376 (2024)
Abstract Background Severe trauma is associated with systemic inflammation and organ dysfunction. Preclinical rodent trauma models are the mainstay of postinjury research but have been criticized for not fully replicating severe human trauma. The aim
Externí odkaz:
https://doaj.org/article/89b941a61a2944e1adf0e4f2fda1475d
Autor:
Sharon A. Andreason, Petrina McKenzie-Reynolds, Kaitlyn M. Whitley, John Coffey, Alvin M. Simmons, Phillip A. Wadl
Publikováno v:
Plants, Vol 13, Iss 9, p 1267 (2024)
Sweet potato leaf curl virus (SPLCV) is a whitefly-transmitted begomovirus infecting sweetpotato and other morning glory (Convolvulaceae) species worldwide. The virus is widespread at the USDA, ARS, U.S. Vegetable Laboratory (USVL), and testing of ge
Externí odkaz:
https://doaj.org/article/3c3b6afa5b374202a3ed84b593686721
Autor:
Chang Sun, Jeannelyn S. Estrella, Elizabeth M. Whitley, Gilda P. Chau, Guillermina Lozano, Amanda R. Wasylishen
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 8 (2022)
Genome sequencing has revealed the importance of epigenetic regulators in tumorigenesis. The genes encoding the chromatin remodeling complex DAXX:ATRX are frequently mutated in pancreatic neuroendocrine tumors; however, the underlying mechanisms of h
Externí odkaz:
https://doaj.org/article/1d796c1cc30249a89d86ee96573ada87
Autor:
Deepavali Chakravarti, Baoli Hu, Xizeng Mao, Asif Rashid, Jiexi Li, Jun Li, Wen-ting Liao, Elizabeth M. Whitley, Prasenjit Dey, Pingping Hou, Kyle A. LaBella, Andrew Chang, Guocan Wang, Denise J. Spring, Pingna Deng, Di Zhao, Xin Liang, Zhengdao Lan, Yiyun Lin, Sharmistha Sarkar, Christopher Terranova, Yonathan Lissanu Deribe, Sarah E. Blutt, Pablo Okhuysen, Jianhua Zhang, Eduardo Vilar, Ole Haagen Nielsen, Andrew Dupont, Mamoun Younes, Kalyani R. Patel, Noah F. Shroyer, Kunal Rai, Mary K. Estes, Y. Alan Wang, Alison A. Bertuch, Ronald A. DePinho
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
How telomere dysfunction is directly linked to inflammation in humans is currently unclear. Here the authors reveal that telomere dysfunction drives activation of the YAP1 transcription factor, up-regulating the pro inflammatory factor, pro-IL-18 thu
Externí odkaz:
https://doaj.org/article/b5a35bee98a746039f8bae5793248657
Autor:
Rahul A. Sheth, Xiaoxia Wen, Junjie Li, Marites P. Melancon, Xin Ji, Y. Andrew Wang, Cheng-Hui Hsiao, Diana S.-L. Chow, Elizabeth M. Whitley, Chun Li, Sanjay Gupta
Publikováno v:
Cancer Nanotechnology, Vol 11, Iss 1, Pp 1-16 (2020)
Abstract Background Doxorubicin-loaded hollow gold nanospheres (Dox@HAuNS) are a promising technology for simultaneous trans-arterial tumor-targeted chemotherapy delivery and thermal ablation. We evaluated the efficacy of intra-arterial delivery of D
Externí odkaz:
https://doaj.org/article/fc608bb790744ab18ce8eb0c052fa93d
Autor:
Jovanka Gencel-Augusto, Xiaoping Su, Yuan Qi, Elizabeth M. Whitley, Vinod Pant, Shunbin Xiong, Vrutant Shah, Jerome Lin, Encarnacion Perez, Marta L. Fiorotto, Iqbal Mahmud, Abhinav K. Jain, Philip L. Lorenzi, Nicholas E. Navin, Ellen R. Richie, Guillermina Lozano
Publikováno v:
Cancer Discovery. 13:1230-1249
Cancer-related alterations of the p53 tetramerization domain (TD) abrogate wild-type (WT) p53 function. They result in a protein that preferentially forms monomers or dimers, which are also normal p53 states under basal cellular conditions. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec38a26d586b90444ae5702d92d18536
https://doi.org/10.1158/2159-8290.cd-22-0872
https://doi.org/10.1158/2159-8290.cd-22-0872
Autor:
Jennifer A. Munley, Lauren S. Kelly, Erick E. Pons, Kolenkode B. Kannan, Preston S. Coldwell, Elizabeth M. Whitley, Gwendolyn S. Gillies, Philip A. Efron, Ravinder Nagpal, Alicia M. Mohr
Publikováno v:
Journal of Trauma and Acute Care Surgery. 94:15-22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c706e462a9e0878bdcb56e658be73da9
https://doi.org/10.1097/ta.0000000000003803
https://doi.org/10.1097/ta.0000000000003803
Autor:
Matthew D. Howell, Eric W. Ottesen, Natalia N. Singh, Rachel L. Anderson, Joonbae Seo, Senthilkumar Sivanesan, Elizabeth M. Whitley, Ravindra N. Singh
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-18 (2017)
Abstract Spinal muscular atrophy (SMA) is caused by deletions or mutations of Survival Motor Neuron 1 (SMN1) gene. The nearly identical SMN2 cannot compensate for SMN1 loss due to exon 7 skipping. The allele C (C +/+) mouse recapitulates a mild SMA-l
Externí odkaz:
https://doaj.org/article/52d3ab15d6f44118a9db9e9a35596a5b
Autor:
Dhruv Chachad, Lalit R. Patel, Carlos Vera. Recio, Rasoul Pourebrahim, Elizabeth M. Whitley, Wenyi Wang, Xiaoping Su, An Xu, Dung-Fang Lee, Guillermina Lozano
Publikováno v:
Cancer Research.
Missense mutations in the DNA binding domain of p53 are characterized as structural or contact mutations based on their effect on the conformation of the protein. These mutations show gain-of-function activities, such as promoting increased metastati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a88bad43552017794455c0d2b09226e2
https://doi.org/10.1158/0008-5472.can-22-3464
https://doi.org/10.1158/0008-5472.can-22-3464
Autor:
Guillermina Lozano, Ellen R. Richie, Nicholas E. Navin, Philip L. Lorenzi, Abhinav K. Jain, Iqbal Mahmud, Marta L. Fiorotto, Encarnacion Perez, Jerome Lin, Vrutant Shah, Shunbin Xiong, Vinod Pant, Elizabeth M. Whitley, Yuan Qi, Xiaoping Su, Jovanka Gencel-Augusto
Cancer-related alterations of the p53 tetramerization domain (TD) abrogate wild-type (WT) p53 function. They result in a protein that preferentially forms monomers or dimers, which are also normal p53 states under basal cellular conditions. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d9976fcab245f95317df38198617cf8
https://doi.org/10.1158/2159-8290.c.6603197.v2
https://doi.org/10.1158/2159-8290.c.6603197.v2
