Zobrazeno 1 - 10
of 188
pro vyhledávání: '"M, Welford"'
Autor:
Chris Montoya, Benjamin Spieler, Scott M. Welford, Deukwoo Kwon, Alan Dal Pra, Gilberto Lopes, Ivaylo B. Mihaylov
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundImmune checkpoint inhibitor (ICI) therapy is first-line treatment for many advanced non-small cell lung cancer (aNSCLC) patients. Predicting response could help guide selection of intensified or alternative anti-cancer regimens. We hypothes
Externí odkaz:
https://doaj.org/article/b33eb55dc7334ed2b35aa09f0c109adb
Publikováno v:
Current Research in Pharmacology and Drug Discovery, Vol 3, Iss , Pp 100076- (2022)
The imidazolium compound Sepantronium Bromide (YM155) successfully promotes tumor regression in various pre-clinical models but has shown modest responses in human clinical trials. We provide evidence to support that the hypoxic milieu of tumors may
Externí odkaz:
https://doaj.org/article/c61beb927faf4a148126db38e9c55b90
Autor:
David Danielpour, Zhaofeng Gao, Patrick M. Zmina, Eswar Shankar, Benjamin C. Shultes, Raul Jobava, Scott M. Welford, Maria Hatzoglou
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Abstract The imidazolium compound YM155, first discovered as a potent inhibitor of Survivin, effectively kills many carcinomas in preclinical models. However, the upstream signaling mechanism triggered by YM155 remains unclear. Here we studied early
Externí odkaz:
https://doaj.org/article/413a98d689b543009470d4c60ab64d4b
Autor:
Vijay S Thakur, Scott M Welford
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240256 (2020)
Modulation of gene activity by creating mutations has contributed significantly to the understanding of protein functions. Oftentimes, however, mutational analyses use overexpression studies, in which proteins are taken out of their normal contexts a
Externí odkaz:
https://doaj.org/article/9abfbd65bad740018114e165cc60570e
Publikováno v:
Nature Reviews Urology. 20:48-60
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f90d4d09b4a227886f42eee464c8928
https://doi.org/10.1038/s41585-022-00654-6
https://doi.org/10.1038/s41585-022-00654-6
Autor:
Weinan Du, Luchang Zhang, Adina Brett-Morris, Brittany Aguila, Janos Kerner, Charles L. Hoppel, Michelle Puchowicz, Dolors Serra, Laura Herrero, Brian I. Rini, Steven Campbell, Scott M. Welford
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Clear cell renal cancers (ccRCC) display elevated intracellular lipid storage. Here the authors show that such lipid accumulation is due to the repression of carnitine palmitoyltransferase 1A (CPT1A) enzyme that impairs fatty acid (FA) transport into
Externí odkaz:
https://doaj.org/article/cc5068c04902403e806e57ccd56d51a2
Autor:
Scott M. Welford, Timothy J. Garrett, J. Mark Brown, Mark L. Gonzalgo, Hamzah H. Ahmed, Marco Dispagna, Rutulkumar Patel, Anthony J. Griswold, Chase K.A. Neumann, Michelle Puchowicz, Flavia Fontanesi, Iqbal Mahmud, Sze Kiat Tan
Clear cell renal cell carcinoma (ccRCC) is characterized by accumulation of neutral lipids and adipogenic transdifferentiation. We assessed adipokine expression in ccRCC and found that tumor tissues and patient plasma exhibit obesity-dependent elevat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d8beb65534517c82e48e504f1d88b35
https://doi.org/10.1158/2159-8290.c.6549287
https://doi.org/10.1158/2159-8290.c.6549287
Autor:
Scott M. Welford, Timothy J. Garrett, J. Mark Brown, Mark L. Gonzalgo, Hamzah H. Ahmed, Marco Dispagna, Rutulkumar Patel, Anthony J. Griswold, Chase K.A. Neumann, Michelle Puchowicz, Flavia Fontanesi, Iqbal Mahmud, Sze Kiat Tan
Differential expression of genes between ccRCC cluster and normal cluster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78fe703c1bdfd36f7e46a45f9feae3a4
https://doi.org/10.1158/2159-8290.22540118
https://doi.org/10.1158/2159-8290.22540118
Autor:
Scott M. Welford, Timothy J. Garrett, J. Mark Brown, Mark L. Gonzalgo, Hamzah H. Ahmed, Marco Dispagna, Rutulkumar Patel, Anthony J. Griswold, Chase K.A. Neumann, Michelle Puchowicz, Flavia Fontanesi, Iqbal Mahmud, Sze Kiat Tan
Supplementary data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a81c3092a6b6aa42722a4b7ee555959c
https://doi.org/10.1158/2159-8290.22540124.v1
https://doi.org/10.1158/2159-8290.22540124.v1
Autor:
Scott M. Welford, Zheng-Rong Lu, Rebecca Schur, Maneesh Gujrati, Eli E. Bar, Raffaella Spina, Jun Lu, Junran Zhang, Vinay Pasupuleti, Yuji Seo, Bradley M. Wright, Adina Brett-Morris
Supplementary table and figures 1-3. Table 1: combined list of screen data identifying 10 genes that commonly sensitize cells to radiation when knocked down. S1: Western blot confirming knockdown of SAT1. S2: Expression of SAT1 in control and shSAT1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90da0dc0de212e9e5c9791811a629fd8
https://doi.org/10.1158/0008-5472.22404219
https://doi.org/10.1158/0008-5472.22404219