Zobrazeno 1 - 10
of 2 269
pro vyhledávání: '"M, Watt"'
Autor:
J. Porter Hunt, Samuel Dubinsky, Autumn M. McKnite, Kit Wun Kathy Cheung, Bianca D. vanGroen, Kathleen M. Giacomini, Saskia N. deWildt, Andrea N. Edginton, Kevin M. Watt
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 4, Pp 576-588 (2024)
Abstract Optimal treatment of infants with many renally cleared drugs must account for maturational differences in renal transporter (RT) activity. Pediatric physiologically‐based pharmacokinetic (PBPK) models may incorporate RT activity, but this
Externí odkaz:
https://doaj.org/article/7ff55455941a418ca3f7d873a040d3c9
Publikováno v:
FACETS, Vol 9, Iss , Pp 1-9 (2024)
Reintroduction is an important tool in the conservation and recovery of aquatic species at risk. However, components of the reintroduction process such as transportation have the potential to induce physiological stress and the extent to which prepar
Externí odkaz:
https://doaj.org/article/5f26b548424648339e00468c729097ad
Autor:
Jae-Seung Moon, Chun-Chang Ho, Jong-Hyun Park, Kyungsoo Park, Bo-Young Shin, Su-Hyeon Lee, Ines Sequeira, Chin Hee Mun, Jin-Su Shin, Jung-Ho Kim, Beom Seok Kim, Jin-Wook Noh, Eui-Seon Lee, Ji Young Son, Yuna Kim, Yeji lee, Hee Cho, SunHyeon So, Jiyoon Park, Eunsu Choi, Jong-Won Oh, Sang-Won Lee, Tomohiro Morio, Fiona M. Watt, Rho Hyun Seong, Sang-Kyou Lee
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Regulatory T cells (Treg) are CD4+ T cells with immune-suppressive function, which is defined by Foxp3 expression. However, the molecular determinants defining the suppressive population of T cells have yet to be discovered. Here we report t
Externí odkaz:
https://doaj.org/article/30fe99c8dc81417bb8c86c7001ea37c0
Autor:
Michele Avissar-Whiting, Frédérique Belliard, Stefano M Bertozzi, Amy Brand, Katherine Brown, Géraldine Clément-Stoneham, Stephanie Dawson, Gautam Dey, Daniel Ecer, Scott C Edmunds, Ashley Farley, Tara D Fischer, Maryrose Franko, James S Fraser, Kathryn Funk, Clarisse Ganier, Melissa Harrison, Anna Hatch, Haley Hazlett, Samantha Hindle, Daniel W Hook, Phil Hurst, Sophien Kamoun, Robert Kiley, Michael M Lacy, Marcel LaFlamme, Rebecca Lawrence, Thomas Lemberger, Maria Leptin, Elliott Lumb, Catriona J MacCallum, Christopher Steven Marcum, Gabriele Marinello, Alex Mendonça, Sara Monaco, Kleber Neves, Damian Pattinson, Jessica K Polka, Iratxe Puebla, Martyn Rittman, Stephen J Royle, Daniela Saderi, Richard Sever, Kathleen Shearer, John E Spiro, Bodo Stern, Dario Taraborelli, Ron Vale, Claudia G Vasquez, Ludo Waltman, Fiona M Watt, Zara Y Weinberg, Mark Williams
Publikováno v:
PLoS Biology, Vol 22, Iss 2, p e3002502 (2024)
Peer review is an important part of the scientific process, but traditional peer review at journals is coming under increased scrutiny for its inefficiency and lack of transparency. As preprints become more widely used and accepted, they raise the po
Externí odkaz:
https://doaj.org/article/f7671182619f4d25a357cd58e213eba8
Autor:
Samuel D.J. Dubinsky, PharmD, Kevin M. Watt, MD, PhD, Carina E. Imburgia, BSc, Autumn M. Mcknite, BSc, J. Porter Hunt, PhD, Cassandra Rice, PhD, Joseph E. Rower, PhD, DABCP, Andrea N. Edginton, PhD
Publikováno v:
Critical Care Explorations, Vol 5, Iss 12, p e1010 (2023)
OBJECTIVES:. Patients with sepsis are at significant risk for multiple organ dysfunction, including the lungs and kidneys. To manage the morbidity associated with kidney impairment, continuous renal replacement therapy (CRRT) may be required. The ext
Externí odkaz:
https://doaj.org/article/594b1e7149d64ebb8c4dc94f0d2a2b8c
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 4 (2023)
ABSTRACT The stringent response enables bacteria to survive nutrient starvation, antibiotic challenge, and other threats to cellular survival. Two alarmone (magic spot) second messengers, guanosine pentaphosphate (pppGpp) and guanosine tetraphosphate
Externí odkaz:
https://doaj.org/article/45bf52a7fb7042a2bca0966c2adaa1f8
Autor:
James Williams, Chloe Hurling, Sabrina Munir, Peter Harley, Carolina Barcellos Machado, Ana-Maria Cujba, Mario Alvarez-Fallas, Davide Danovi, Ivo Lieberam, Rocio Sancho, Philip Beales, Fiona M. Watt
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Bardet-Biedl syndrome (BBS) is a ciliopathy with pleiotropic effects on multiple tissues, including the kidney. Here we have compared renal differentiation of iPS cells from healthy and BBS donors. High content image analysis of WT1-expressing kidney
Externí odkaz:
https://doaj.org/article/d171a7913adc46668842c8c82971940f
Autor:
Anna Pató, Kata Bölcskei, Ágnes Donkó, Diána Kaszás, Melinda Boros, Lilla Bodrogi, György Várady, Veronika F.S. Pape, Benoit T. Roux, Balázs Enyedi, Zsuzsanna Helyes, Fiona M. Watt, Gábor Sirokmány, Miklós Geiszt
Publikováno v:
Redox Biology, Vol 62, Iss , Pp 102670- (2023)
Keratinocytes of the mammalian skin provide not only mechanical protection for the tissues, but also transmit mechanical, chemical, and thermal stimuli from the external environment to the sensory nerve terminals. Sensory nerve fibers penetrate the e
Externí odkaz:
https://doaj.org/article/1c2265ef3af44926b8a13f251ef3f07b
Autor:
Jacqueline G. Gerhart, Fernando O. Carreño, Jennifer L. Ford, Andrea N. Edginton, Eliana M. Perrin, Kevin M. Watt, William J. Muller, Andrew M. Atz, Amira Al‐Uzri, Paula Delmore, Daniel Gonzalez, Best Pharmaceuticals for Children Act–Pediatric Trials Network Steering Committee
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 6, Pp 778-791 (2022)
Abstract Obesity is an increasingly alarming public health threat, with nearly 20% of children classified as obese in the United States today. Children with obesity are commonly prescribed the opioids fentanyl and methadone, and accurate dosing is cr
Externí odkaz:
https://doaj.org/article/dd4ab2e51fa44b86a239b72f4ea91718
Autor:
Jonathan E Constance, Mary M McFarland, Tallie Casucci, Michael W Deininger, Elena Y Enioutina, Kathleen Job, Richard S Lemons, Carol S Lim, Robert M Ward, Venkata Yellepeddi, Kevin M Watt
Publikováno v:
JMIR Research Protocols, Vol 12, p e38167 (2023)
BackgroundNumerous reports contend opioids can augment or inhibit malignancy. At present, there is no consensus on the risk or benefit posed by opioids on malignancy or chemotherapeutic activity. Distinguishing the consequences of opioid use from pai
Externí odkaz:
https://doaj.org/article/01de88bf0bb141f3bfea67eaff1c11ed