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Autor: M. van Heek, H. Davis

Publikováno v: European Heart Journal Supplements. 4:J5-J8

Ezetimibe is the first of the cholesterol absorption inhibitors, a novel class of lipid modifying drugs, which potently inhibit the absorption of biliary and dietary cholesterol from the small intestine without affecting the absorption of fat-soluble

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7657271d4818deb59ba7172e0ce9fc2d
https://doi.org/10.1016/s1520-765x(02)90076-3

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Akademický článek

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Leptin increases energy expenditure and selectively promotes fat metabolism in ob/ob mice

Autor: M. P. Graziano, M. van Heek, M. Rudinski, Edmund J. Sybertz, Ahmad Fawzi, Lorraine Ghibaudi, P. Williams, Joyce J. Hwa, Catherine D. Strader, H. Davis

Publikováno v: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 272:R1204-R1209

Obesity occurs whenever energy intake exceeds energy expenditure. The ob gene product leptin is a potent anorectic agent when administered to ob/ob mice, but its effects on energy expenditure have not been investigated in detail. The present study wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83bf5dd2ae017600c6b8e5863f12353e
https://doi.org/10.1152/ajpregu.1997.272.4.r1204

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The Liptin Haemopoietic Cytokine Fold is Stabilized by an Intrachain Disulfide Bond

Autor: Rock Fl, M. van Heek, J. F. Bazan, Scott W. Altmann, R. A. Kastelein

Publikováno v: Hormone and Metabolic Research. 28:649-652

Structure prediction algorithms have tagged leptin as the newest member of the haemopoietic cytokine family, a diverse class of secreted hormone-like factors with pleiotropic effects in immunity and haemopoietic development. While haemopoietic cytoki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad86fb63e969516d8988f36d8cf43bc8
https://doi.org/10.1055/s-2007-979871

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The Relationship of Tissue Localization, Distribution and Turnover to Feeding After Intraperitoneal125I-Leptin Administration toob/obanddb/dbMice

Autor: M. Van Heek, D. Mullins, M. Wirth, M. Graziano, A. Fawzi, D. Compton, C. France, L. Hoos, R. Casale, E. Sybertz, C. Strader, H. Davis

Publikováno v: Hormone and Metabolic Research. 28:653-658

Brain and whole body localization and distribution of 125I-leptin was determined after intraperitoneal administration to ob/ob and db/db mice, and was compared to inhibition of food intake. Food intake was not significantly inhibited at3 hours post-i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad789729da172219ff3b11618b3bb333
https://doi.org/10.1055/s-2007-979872

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ChemInform Abstract: (-)-SCH 57939: Synthesis and Pharmacological Properties of a Potent, Metabolically Stable Cholesterol Absorption Inhibitor

Autor: Keith Huie, M. van Heek, H. R. Jun. Davis, B. B. Shankar, Douglas S Compton, Sue Ing Lin, Stuart W. McCombie, Andrew T. McPhail, Razia Rizvi, Sundeep Dugar, Yumibe Nathan P, Kirkup Michael P, J. W. Clader

Publikováno v: ChemInform. 27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8cbe1674e18ed323f5a899e941a95bbc
https://doi.org/10.1002/chin.199652130

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ChemInform Abstract: Metabolism and Structure Activity Data Based Drug Design: Discovery of (-)SCH 53079 (Ia), an Analogue of the Potent Cholesterol Absorption Inhibitor (-)SCH 48461 (Ib)

Autor: Yumibe Nathan P, Sundeep Dugar, M. van Heek, J. W. Clader, Douglas S Compton, H. R. Jun. Davis, M. Vizziano, Keith Huie

Publikováno v: ChemInform. 27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::210a99a65646e0851574d691c6e09f36
https://doi.org/10.1002/chin.199642242

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Mechanisms of hypertriglyceridemia in the coconut oil/cholesterol-fed rabbit. Increased secretion and decreased catabolism of very low density lipoprotein

Autor: M Van Heek, Donald B. Zilversmit

Publikováno v: Arteriosclerosis and Thrombosis: A Journal of Vascular Biology. 11:918-927

Rabbits fed a 14% coconut oil/0.5% cholesterol (CNO/Chol) diet develop mild to severe hypertriglyceridemia compared with rabbits fed a 14% olive oil/0.5% cholesterol (OO/Chol) diet. Lipids and apolipoprotein (apo) B were significantly higher in the v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79eaaf0e47bdafb47640b86b6bdea052
https://doi.org/10.1161/01.atv.11.4.918

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Postprandial lipemia and lipoprotein lipase in the rabbit are modified by olive and coconut oil

Autor: M Van Heek, Donald B. Zilversmit

Publikováno v: Arteriosclerosis: An Official Journal of the American Heart Association, Inc.. 10:421-429

Feeding a 14% coconut oil/0.5% cholesterol (CNO/chol) diet to rabbits resulted in plasma triglycerides that were, on average, 15 times higher than basal levels. Plasma triglycerides in rabbits fed a 14% olive oil/0.5% cholesterol (OO/chol) diet were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9280e366a661f8630db0c6c73195ff72
https://doi.org/10.1161/01.atv.10.3.421

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