Zobrazeno 1 - 10
of 94
pro vyhledávání: '"M, Unkila"'
Publikováno v:
Regulatory Toxicology and Pharmacology, 1, 40, 1-8
Plant lignan 7-hydromatairesinol, a novel precursor of the mammalian lignan enterolactone was evaluated in a prenatal developmental toxicity study conducted in the Wistar rat. Mated female rats were fed diets containing 0, 0.25, 1, and 4% (w/w) of 7-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbfa844a2547c7145bffc7dbffe85790
https://doi.org/10.1016/j.yrtph.2004.04.001
https://doi.org/10.1016/j.yrtph.2004.04.001
Autor:
Elin Torvaldson, Thomas Holmbom, H Stykki, Emilia Peuhu, Rainer Sjöholm, M Unkila, Adolfo Rivero-Müller, Patrik Eklund, John E. Eriksson
Publikováno v:
Oncogene. 29(6)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to be selectively pro-apoptotic in cancer cells, with minimal toxicity to normal tissues. Although this feature makes TRAIL a promising anticancer agent, not all cancer ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9ee744ceb3db602fd30c78b02af1f1
https://pubmed.ncbi.nlm.nih.gov/19935713
https://pubmed.ncbi.nlm.nih.gov/19935713
Autor:
Diego Di Lorenzo, Luigi Caimi, M. Jeremic, M. Unkila, Giovanna Mazzoleni, Claudia Montani, M. Penza
Publikováno v:
Università degli Studi di Brescia-IRIS
Alternatives to animal testing and the identification of reliable methods that may decrease the need for animals are currently the subject of intense investigation worldwide. Alternative testing procedures are particularly important for synthetic and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12fb71666b0ac6312980380705f8ce3a
http://hdl.handle.net/11379/32325
http://hdl.handle.net/11379/32325
Autor:
H Uusitalo, Tuomas Ryhänen, Jari Hyttinen, Antero Salminen, Johanna Viiri, M Unkila, Kai Kaarniranta, Tuomas Paimela
Publikováno v:
Acta Ophthalmologica. 86
Purpose Recent findings reveal that Toll-like receptors (TLRs) and innate immunity participate in the pathology of age-related macular degeneration (AMD). Many studies indicate that estrogens and selective estrogen modulators (SERMs) modulate inflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51261ca646a35b2d7dca9d7f6a79e7d0
https://doi.org/10.1111/j.1755-3768.2008.410.x
https://doi.org/10.1111/j.1755-3768.2008.410.x
Publikováno v:
Regulatory Toxicology and Pharmacology, 1, 41, 28-38
Plant lignan 7-hydroxymatairesinol (7-HMR) is a novel precursor of the mammalian lignan enterolactone. A 13 week toxicity study at dietary levels of 0, 0.25, 1, and 4% (w/w) of potassium acetate complex of 7-HMR (HMRlignan) was conducted in the Wista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a99604705458c09198f72d9c859c69e8
https://pubmed.ncbi.nlm.nih.gov/15649825
https://pubmed.ncbi.nlm.nih.gov/15649825
Publikováno v:
Advances in experimental medicine and biology. 467
Polychlorinated dioxins (PCDD) are widespread environmental contaminants. The most potent and the general model compound for dioxins is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Our laboratory has developed a new model for studies of dioxin toxicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::048c2e2118e8eb712180251d538e0cb2
https://pubmed.ncbi.nlm.nih.gov/10721086
https://pubmed.ncbi.nlm.nih.gov/10721086
Publikováno v:
Pharmacology, biochemistry, and behavior. 62(4)
Interactions of diet and diet-induced obesity, and the characteristic wasting syndrome caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) were studied in TCDD-resistant Han/Wistar and TCDD-sensitive Long-Evans rats. The rats were made obese by feed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e91be620bf5ea4a21aecb722261d395d
https://pubmed.ncbi.nlm.nih.gov/10208380
https://pubmed.ncbi.nlm.nih.gov/10208380
Publikováno v:
Biochemical pharmacology. 46(4)
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a potent inducer of ethoxyresorufin O-deethylase (EROD) and aldehyde dehydrogenase (EC 1.2.1.3., ALDH3) enzyme activities in the liver. Little is known about their inducibility by TCDD in the brain, altho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2098bbb225d87768f0926369526645e4
https://pubmed.ncbi.nlm.nih.gov/8363638
https://pubmed.ncbi.nlm.nih.gov/8363638
Publikováno v:
Agents and actions. 33(1-2)
Histaminergic neurones may be involved in the regulation of feed intake. Since TCDD causes anorexia in rats, histamine concentrations were measured in several hypothalamic nuclei involved in feeding regulation. Histamine concentrations were not chang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d47aaec2d73c698a1de2152c0e26a78
https://pubmed.ncbi.nlm.nih.gov/1897433
https://pubmed.ncbi.nlm.nih.gov/1897433
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