Zobrazeno 1 - 10
of 105
pro vyhledávání: '"M, Tyc"'
Autor:
Quinn T. Easter, Bruno Fernandes Matuck, Germán Beldorati Stark, Catherine L. Worth, Alexander V. Predeus, Brayon Fremin, Khoa Huynh, Vaishnavi Ranganathan, Zhi Ren, Diana Pereira, Brittany T. Rupp, Theresa Weaver, Kathryn Miller, Paola Perez, Akira Hasuike, Zhaoxu Chen, Mandy Bush, Xufeng Qu, Janice Lee, Scott H. Randell, Shannon M. Wallet, Inês Sequeira, Hyun Koo, Katarzyna M. Tyc, Jinze Liu, Kang I. Ko, Sarah A. Teichmann, Kevin M. Byrd
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Periodontitis affects billions of people worldwide. To address relationships of periodontal niche cell types and microbes in periodontitis, we generated an integrated single-cell RNA sequencing (scRNAseq) atlas of human periodontium (34-samp
Externí odkaz:
https://doaj.org/article/e25d449cf5024f9e90cca5df87ff4c19
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106082- (2023)
Summary: KRAS mutations are prevalent in pancreatic and lung cancers, but not all mutant (mt) KRAS tumors are addicted to mt KRAS. Here, we discovered a 30-gene transcriptome signature “KDS30” that encodes a novel EGFR/ERBB2-driven signaling netw
Externí odkaz:
https://doaj.org/article/d36dcf12c3fb495b80f4008e28cd2572
Autor:
Victor M. Tan, Shengkan Jin, Katarzyna M. Tyc, Melany Ruiz-Urigüen, Jennifer A. Harbottle, Ceri M. Wiggins, Juan Collantes, Jinchuan Xing, John J. Lambourne, Hanlin Tao, Chi Su, Amer Alasadi, Jingjing Guo, Huiting Xu, Tommaso Selmi, Jesse Stombaugh
Publikováno v:
CRISPR J
Conventional CRISPR approaches for precision genome editing rely on the introduction of DNA double-strand breaks (DSB) and activation of homology-directed repair (HDR), which is inherently genotoxic and inefficient in somatic cells. The development o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b22b5ff1417128252b11da8202ac8a
https://doi.org/10.1089/crispr.2020.0035
https://doi.org/10.1089/crispr.2020.0035
Autor:
J. Landis, Nathan R. Treff, Jinchuan Xing, Aishee Bag, Richard T. Scott, Yiping Zhan, Katarzyna M. Tyc, Warif El Yakoubi, Karen Schindler, Xin Tao
Publikováno v:
Hum Reprod
STUDY QUESTION What are the genetic factors that increase the risk of aneuploid egg production? SUMMARY ANSWER A non-synonymous variant rs2303720 within centrosomal protein 120 (CEP120) disrupts female meiosis in vitro in mouse. WHAT IS KNOWN ALREADY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cffded38d68341947a6a719302405344
https://doi.org/10.1093/humrep/deaa148
https://doi.org/10.1093/humrep/deaa148
Publikováno v:
Frontiers in Microbiology, Vol 5 (2014)
A range of attributes determines the virulence of human pathogens. During interactions with their hosts, pathogenic microbes often undergo transitions between distinct stages, and the ability to switch between these can be directly related to the dis
Externí odkaz:
https://doaj.org/article/4b1cb6afbc5f4afe9714859d304ecbf6
Autor:
Jeff Dupree, Tomasz Kordula, Karli Mockenhaupt, Katarzyna M. Tyc, Debolina D. Biswas, Michael R. Waters, Angela S. Gupta, Sandeep Singh, Adam Rory McQuiston, Mikhail G. Dozmorov, Avani Hariprashad, Amy L. Olex
Diverse subpopulations of astrocytes tile different brain regions to accommodate local requirements of neurons and associated neuronal circuits. Nevertheless, molecular mechanisms governing astrocyte diversity remain mostly unknown. We explored the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c07568efd313ecb60ec47070c370742
https://doi.org/10.1101/2021.05.14.444129
https://doi.org/10.1101/2021.05.14.444129
Autor:
Katarzyna M. Tyc, Amy L. Olex, J. Chuck Harrell, Mikhail G. Dozmorov, Nathan C. Sheffield, Jason Reed, David C. Boyd
Publikováno v:
Gigascience
Background Sequencing of patient-derived xenograft (PDX) mouse models allows investigation of the molecular mechanisms of human tumor samples engrafted in a mouse host. Thus, both human and mouse genetic material is sequenced. Several methods have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f48f2ac6f45eb2e60736920e0dfec5c
https://pubmed.ncbi.nlm.nih.gov/33880552
https://pubmed.ncbi.nlm.nih.gov/33880552
Autor:
Leelabati Biswas, Katarzyna M. Tyc, Katie Morgan, Warif El Yakoubi, Karen Schindler, Jinchuan Xing
Publikováno v:
Reproduction
Idiopathic or ‘unexplained’ infertility represents as many as 30% of infertility cases worldwide. Conception, implantation, and term delivery of developmentally healthy infants require chromosomally normal (euploid) eggs and sperm. The crux of eu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd93cf7cd9f95c3ef7c219daf3807583
https://pubmed.ncbi.nlm.nih.gov/33170803
https://pubmed.ncbi.nlm.nih.gov/33170803
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology
Early human embryogenesis relies on maternal gene products accumulated during oocyte growth and maturation, until around day-3 post-fertilization when human zygotic genome activation occurs. The maternal-to-zygotic transition (MZT) is a tightly coord
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1d2921b09db985be0b3ffefa97ac2db
https://pubmed.ncbi.nlm.nih.gov/33070169
https://pubmed.ncbi.nlm.nih.gov/33070169
Publikováno v:
Proc Natl Acad Sci U S A
Aneuploidy is the leading contributor to pregnancy loss, congenital anomalies, and in vitro fertilization (IVF) failure in humans. Although most aneuploid conceptions are thought to originate from meiotic division errors in the female germline, quant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1299d6a68ee27873ff7690178e3b76fe
https://europepmc.org/articles/PMC7229693/
https://europepmc.org/articles/PMC7229693/