Zobrazeno 1 - 10
of 100
pro vyhledávání: '"M, Tumolo"'
Publikováno v:
eLife, Vol 9 (2020)
Ubiquitination regulates many different cellular processes, including protein quality control, membrane trafficking, and stress responses. The diversity of ubiquitin functions in the cell is partly due to its ability to form chains with distinct link
Externí odkaz:
https://doaj.org/article/9ee6ebe9c5704e8283ef288fb9d2227b
Publikováno v:
PLoS Genetics, Vol 16, Iss 3, p e1008677 (2020)
Endocytosis is regulated in response to changing environmental conditions to adjust plasma membrane (PM) protein composition for optimal cell growth. Protein networks involved in cargo capture and sorting, membrane sculpting and deformation, and vesi
Externí odkaz:
https://doaj.org/article/60b609c2984c4393928320121e845d85
Akademický článek
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Autor:
Sora Lee, Jessica M Tumolo, Aaron C Ehlinger, Kristin K Jernigan, Susan J Qualls-Histed, Pi-Chiang Hsu, W Hayes McDonald, Walter J Chazin, Jason A MacGurn
Publikováno v:
eLife, Vol 6 (2017)
Despite its central role in protein degradation little is known about the molecular mechanisms that sense, maintain, and regulate steady state concentration of ubiquitin in the cell. Here, we describe a novel mechanism for regulation of ubiquitin hom
Externí odkaz:
https://doaj.org/article/c7cb9526e5f849d39368b53828016751
Publikováno v:
The Journal of Cell Biology
Lee et al. show that methionine triggers Ppz phosphatase-dependent dephosphorylation of the E3 ubiquitin ligase adaptor Art1. Art1 dephosphorylation promotes its interaction with the methionine transporter Mup1, as well as subsequent endocytosis and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9633463ae4ca7e9e71828f247dc229c9
http://europepmc.org/articles/PMC6400557
http://europepmc.org/articles/PMC6400557
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105830 (2014)
Acid sphingomyelinase (aSMase) is a human enzyme that catalyzes the hydrolysis of sphingomyelin to generate the bioactive lipid ceramide and phosphocholine. ASMase deficiency is the underlying cause of the genetic diseases Niemann-Pick Type A and B a
Externí odkaz:
https://doaj.org/article/ba6bc47a9ad34c81bd6fbaad32556011
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Ubiquitination regulates many different cellular processes, including protein quality control, membrane trafficking, and stress responses. The diversity of ubiquitin functions in the cell is partly due to its ability to form chains with distinct link
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1e51d1588d288f5bef47e020a28d5c1
https://pubmed.ncbi.nlm.nih.gov/33074099
https://pubmed.ncbi.nlm.nih.gov/33074099
Autor:
Thomas J. Gould, David A. Connor, Courtney Cann, Munir Gunes Kutlu, Brendan Garrett, Jessica M. Tumolo
Publikováno v:
Neuropharmacology. 141:192-200
Numerous studies have attributed the psychopathology of anxiety and stress disorders to maladaptive behavioral responses such as an inability to extinguish fear. Therefore, understanding neural substrates of fear extinction is imperative for developi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfcd46b592b542b77eb1f7c66f3418eb
https://doi.org/10.1016/j.neuropharm.2018.08.019
https://doi.org/10.1016/j.neuropharm.2018.08.019
Publikováno v:
Behavioural Brain Research. 341:176-180
Post-traumatic stress disorder (PTSD) is a devastating disorder with symptoms such as flashbacks, hyperarousal, and avoidance of reminders of the traumatic event. Exposure therapy, which attempts to extinguish fear responses, is a commonly used treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed48e2540e7544bdd07ae1ee167a89c7
https://doi.org/10.1016/j.bbr.2018.01.002
https://doi.org/10.1016/j.bbr.2018.01.002