Zobrazeno 1 - 10 of 1 452 pro vyhledávání: '"M, Trybus"'
1
Akademický článek
Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug design
Autor: Dihia Moussaoui, James P. Robblee, Julien Robert-Paganin, Daniel Auguin, Fabio Fisher, Patricia M. Fagnant, Jill E. Macfarlane, Julia Schaletzky, Eddie Wehri, Christoph Mueller-Dieckmann, Jake Baum, Kathleen M. Trybus, Anne Houdusse
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Malaria results in more than 500,000 deaths per year and the causative Plasmodium parasites continue to develop resistance to all known agents, including different antimalarial combinations. The class XIV myosin motor PfMyoA is part of a cor
Externí odkaz: https://doaj.org/article/649b74fa0af0445585a6975102ee7c70
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3
Akademický článek
The actomyosin interface contains an evolutionary conserved core and an ancillary interface involved in specificity
Autor: Julien Robert-Paganin, Xiao-Ping Xu, Mark F. Swift, Daniel Auguin, James P. Robblee, Hailong Lu, Patricia M. Fagnant, Elena B. Krementsova, Kathleen M. Trybus, Anne Houdusse, Niels Volkmann, Dorit Hanein
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Plasmodium falciparum moves by an atypical process called gliding motility which comprises of atypical myosin A (PfMyoA) and filaments of the dynamic and divergent PfActin-1 (PfAct1). Here authors present the cryo-EM structure of PfMyoA bound to fila
Externí odkaz: https://doaj.org/article/1e9f084757d3479aa82cffe48fcd9158
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5
Akademický článek
Coil-to-α-helix transition at the Nup358-BicD2 interface activates BicD2 for dynein recruitment
Autor: James M Gibson, Heying Cui, M Yusuf Ali, Xiaoxin Zhao, Erik W Debler, Jing Zhao, Kathleen M Trybus, Sozanne R Solmaz, Chunyu Wang
Publikováno v: eLife, Vol 11 (2022)
Nup358, a protein of the nuclear pore complex, facilitates a nuclear positioning pathway that is essential for many biological processes, including neuromuscular and brain development. Nup358 interacts with the dynein adaptor Bicaudal D2 (BicD2), whi
Externí odkaz: https://doaj.org/article/4a68972630e44150a18ff81e5f7a70b2
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9
Akademický článek
Plasmodium myosin A drives parasite invasion by an atypical force generating mechanism
Autor: Julien Robert-Paganin, James P. Robblee, Daniel Auguin, Thomas C. A. Blake, Carol S. Bookwalter, Elena B. Krementsova, Dihia Moussaoui, Michael J. Previs, Guillaume Jousset, Jake Baum, Kathleen M. Trybus, Anne Houdusse
Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Here, Robert-Paganin et al. show that myosin A from Plasmodium falciparum is critical for red blood cell invasion and that non-canonical interactions and regulated phosphorylation are important for force generation during parasite invasion.
Externí odkaz: https://doaj.org/article/09a7260cc76747dbb13cb2f561bcbfc8
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