Zobrazeno 1 - 10
of 12
pro vyhledávání: '"M, Träff"'
Publikováno v:
Journal of pharmaceutical sciences. 111(7)
Stability is fundamental when exploring a drug candidate's potential as a drug product. During the pharmaceutical industry drug development process information regarding stability and degradation are captured in different departments, e.g. from disco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a43498e9f4320f54a8b4baa2fbd80217
https://pubmed.ncbi.nlm.nih.gov/34929157
https://pubmed.ncbi.nlm.nih.gov/34929157
Publikováno v:
Organic Letters. 18:2804-2807
A facile iodination protocol of unactivated alkyl fluorides using catalytic amounts of YbI3(THF)3 in the presence of iodotrimethylsilane as a stoichiometric fluoride trapping agent is presented. (1)H NMR spectroscopy demonstrates a two-step catalytic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2636b06e7cf99609374a94679676d3e0
https://doi.org/10.1021/acs.orglett.6b01022
https://doi.org/10.1021/acs.orglett.6b01022
Publikováno v:
Angewandte Chemie International Edition. 52:12073-12076
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b4cdbc0938e1487a4fdcf37b85bf8b
https://doi.org/10.1002/anie.201306104
https://doi.org/10.1002/anie.201306104
Publikováno v:
Chemical communications (Cambridge, England). 51(68)
A mild and distinct methodology for instantaneous β-amino fluoride substitution mediated by La[N(SiMe3)2]3 has been developed. The reaction proceeds via a reactive aziridinium ion intermediate, which readily reacts with various nucleophiles. This al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd6abcde6dc8738e05ccdd9b224b736e
https://pubmed.ncbi.nlm.nih.gov/26224158
https://pubmed.ncbi.nlm.nih.gov/26224158
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 21(9)
A procedure for chemoselectively manipulating the strong aliphatic C-F bond with direct transformation into a C-N bond under mild conditions is reported. The activation and subsequent substitution of primary alkyl fluorides is mediated by La[N(SiMe3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f3150d396ae224f07ef88889e5aaeb
https://pubmed.ncbi.nlm.nih.gov/25601723
https://pubmed.ncbi.nlm.nih.gov/25601723
Publikováno v:
Angewandte Chemie (International ed. in English). 52(46)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::280fb551682740f7d5d7cc90b30bdd4b
https://pubmed.ncbi.nlm.nih.gov/24115642
https://pubmed.ncbi.nlm.nih.gov/24115642
Publikováno v:
Synfacts. 11:0537-0537
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2154bf3fa6bb7e7e9762fbc4e98d11b
https://doi.org/10.1055/s-0034-1380640
https://doi.org/10.1055/s-0034-1380640
Akademický článek
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Publikováno v:
Chemical Communications. 49:1826
Sm(HMDS)(2) in n-hexane mediates fast cleavage of primary, secondary and tertiary alkyl fluorides in good to excellent yields. In n-hexane Sm(HMDS)(2) exhibits uniquely enhanced reductive ability towards the C-F bond compared to when using THF as sol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c3fd13388482f1dfc9b7eab6c092dc
https://doi.org/10.1039/c3cc37828d
https://doi.org/10.1039/c3cc37828d
Publikováno v:
Lakartidningen. 91(20)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6dbeefedc135727e4dfdbe40b54bf6ee
https://pubmed.ncbi.nlm.nih.gov/8057726
https://pubmed.ncbi.nlm.nih.gov/8057726