Zobrazeno 1 - 10
of 328
pro vyhledávání: '"M, Tomasiak"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Yeast Cadmium Factor 1 (Ycf1) sequesters glutathione and glutathione-heavy metal conjugates into yeast vacuoles as a cellular detoxification mechanism. Ycf1 belongs to the C subfamily of ATP Binding Cassette (ABC) transporters characterized
Externí odkaz:
https://doaj.org/article/6821288c06054450bec9a5b11d854742
Autor:
Nitesh Kumar Khandelwal, Cinthia R. Millan, Samantha I. Zangari, Samantha Avila, Dewight Williams, Tarjani M. Thaker, Thomas M. Tomasiak
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Ycf1, a C-family member ATP Binding Cassette (ABC) transporter, transports glutathione and glutathione-metal complexes in yeast. Here the authors use cryo-EM and biochemical analysis to show how an intrinsically-disordered regulatory domain (R-domain
Externí odkaz:
https://doaj.org/article/1b1ddd945c58459bbc161a3c5f0f4886
Autor:
John N. Galgiani, Lisa F. Shubitz, Marc J. Orbach, M. Alejandra Mandel, Daniel A. Powell, Bruce S. Klein, Edward J. Robb, Mana Ohkura, Devin J. Seka, Thomas M. Tomasiak, Thomas P. Monath
Publikováno v:
Journal of Fungi, Vol 8, Iss 8, p 838 (2022)
Coccidioidomycosis is an endemic fungal infection that is reported in up to 20,000 persons per year and has an economic impact close to $1.5 billion. Natural infection virtually always confers protection from future exposure, and this suggests that a
Externí odkaz:
https://doaj.org/article/3ddd8dab5dcf4a8ebd3af2a0e07f0366
Autor:
Tarjani M. Thaker, Smriti Mishra, Wenchang Zhou, Michael Mohan, Qingyu Tang, José D. Faraldo-Goméz, Hassane S. Mchaourab, Thomas M. Tomasiak
Publikováno v:
Nat Chem Biol
Substrate efflux by ATP-binding cassette (ABC) transporters, which play a major role in multidrug resistance, entails the ATP-powered interconversion between transporter intermediates. Despite recent progress in structure elucidation, a number of int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d746f68b777796d20ad39ab71eacfeb
https://doi.org/10.1038/s41589-021-00936-x
https://doi.org/10.1038/s41589-021-00936-x
Autor:
Tarjani M. Thaker, Chyi Chyi Chong, Asmaa S. AbuMaziad, Maureen K. Galindo, H. Eugene Hoyme, Thomas M. Tomasiak
Publikováno v:
American Journal of Medical Genetics Part A. 185:60-67
Background and objectives Glomerulopathies affect kidney glomeruli and can lead to end-stage renal disease if untreated. Clinical and experimental evidence have identified numerous (>20) genetic mutations in the mitochondrial coenzyme Q8B protein (CO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054a8ba6623e3f9418db9f4a30afda36
https://doi.org/10.1002/ajmg.a.61909
https://doi.org/10.1002/ajmg.a.61909
Autor:
Ewa Chabielska, M. M. Tomasiak-Lozowska, Agata Golaszewska, Tomasz Rusak, Marta Iwanicka, Agnieszka Leszczynska, Natalia Marcinczyk, Tomasz Misztal
Publikováno v:
Free Radical Biology and Medicine. 141:426-437
Hypochlorite (HOCl), a strong oxidant and antimicrobial agent, has been proposed to be associated with hemostatic abnormalities during inflammatory response. However, its complex impact on hemostasis is not completely understood. In this report we st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf8f373a4041b2c21c98c336552489c
https://doi.org/10.1016/j.freeradbiomed.2019.07.003
https://doi.org/10.1016/j.freeradbiomed.2019.07.003
Autor:
Thomas M. Tomasiak, Dewight Williams, Zangari Si, Tarjani M. Thaker, Avila S, Cinthia R. Millan, Nitesh Kumar Khandelwal
Yeast Cadmium Factor-1 (Ycf1) sequesters heavy metals and glutathione into the vacuole to counter cell stress. Ycf1 belongs to the ATP binding cassette C-subfamily (ABCC) of transporters, many of which are regulated by phosphorylation on intrinsicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f2cdfb9fe6e89f0f41f24221157947e
https://doi.org/10.1101/2021.06.18.449046
https://doi.org/10.1101/2021.06.18.449046
Autor:
Nitesh Kumar, Khandelwal, Cinthia R, Millan, Samantha I, Zangari, Samantha, Avila, Dewight, Williams, Tarjani M, Thaker, Thomas M, Tomasiak
Publikováno v:
Nature communications. 13(1)
Yeast Cadmium Factor 1 (Ycf1) sequesters heavy metals and glutathione into the vacuole to counter cell stress. Ycf1 belongs to the ATP binding cassette C-subfamily (ABCC) of transporters, many of which are regulated by phosphorylation on intrinsicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7399638b23aaca6559339f7751c27783
https://pubmed.ncbi.nlm.nih.gov/35277487
https://pubmed.ncbi.nlm.nih.gov/35277487
Autor:
José D. Faraldo-Gómez, Tarjani M. Thaker, Thomas M. Tomasiak, Sanjay Mishra, Hassane S. Mchaourab, Weiyin Zhou
Vectorial substrate efflux by ATP binding cassette (ABC) transporters, which play a major role in multidrug resistance, entails the ATP-powered interconversion of the transporter between stable intermediates. Despite recent progress in structure eluc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d2f868360cb62277a4b7c02cef87ad4
https://doi.org/10.1101/2021.03.13.435271
https://doi.org/10.1101/2021.03.13.435271
Autor:
Valery F. Thompson, Tarjani M. Thaker, Martina Francis, Thomas M. Tomasiak, Cinthia R. Millan
The ATP binding cassette (ABC) family of transporters move diverse small molecules across membranes in nearly all organisms. Transport activity requires conformational switching between inward-facing and outward-facing states driven by ATP-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd831d2c17c88211651702cafcce1698
https://doi.org/10.1101/2020.01.12.903617
https://doi.org/10.1101/2020.01.12.903617