Zobrazeno 1 - 10
of 251
pro vyhledávání: '"M, Symann"'
Publikováno v:
European Journal of Clinical Investigation. 28:138-144
Megakaryocyte polyploidization is an advantageous and regulated mechanism that leads to an increase in platelet production. In megakaryocytic cell lines, polyploidization can be obtained by using colchicine, an inhibitor of the tubulin spindle. The n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b05be91f011e07739012909d144ca7
https://doi.org/10.1046/j.1365-2362.1998.00250.x
https://doi.org/10.1046/j.1365-2362.1998.00250.x
Autor:
P.A. Palmer, J. Vinke, T. Philip, S. Negrier, J. Atzpodien, H. Kirchner, R. Oskam, C.R. Franks, H. Von der Maase, N. Thatcher, C. Jasmin, S. Fossa, M. Symann, L. Israel, G. Nagel, G. Stoter, C. Rugarli, O. Eremin, A. Iacone, F. Cleton, J. Janssens, null Willems, L. Bergmann, W. West, R. Oldham, R. Dillman, P. Wiernik, C. Coltman, A. Raynor, J. Doroshow, D. Parkinson, E. Gallignoni, P. Guillou, M. Gore, C. Keen, T. Roberts, A. Harris, M. Fordham, P. Harper, M. Cornbleet, P. Selby, B. Hancock, N. Bleehan, S. Harland, C. Rowland, M. Ostrowski, T. Hamblin, P. Veitch, M. Sokal, P. Abrams, R. Oliver, H. Bodenstein, P. Czygan, P. de Mulder, J. Wils
Publikováno v:
Annals of Oncology. 3:475-480
A database of 327 patients with advanced Renal Cell Carcinoma (RCC) has been analyzed in order to identify potential baseline prognostic factors predicting for survival, following recombinant Interleukin-2 treatment (rIL-2). All patients received a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdbd45ff089389e10b19c003a746f7d7
https://doi.org/10.1093/oxfordjournals.annonc.a058239
https://doi.org/10.1093/oxfordjournals.annonc.a058239
Autor:
F. C. Monette, P Quesenberry, Kevin A. Rickard, Donald Howard, Alec Morley, Frederick Stohlman, William S. Tyler, M. Symann, Eero Niskanen
Publikováno v:
Ciba Foundation Symposium 13-Haemopoietic Stem Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af5be7827d955cb0b7c6d1f12bb458c0
https://doi.org/10.1002/9780470719961.ch9
https://doi.org/10.1002/9780470719961.ch9
Publikováno v:
European Respiratory Journal. 3:699-714
Despite disappointing results in the treatment of small cell lung cancer (SCLC), major progress in our understanding of SCLC biology has occurred in the past decade. Advances in the technique for culturing SCLC tumours in vitro have greatly facilitat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0792d1ab265e668076da7798fdbfb71
https://doi.org/10.1183/09031936.93.03060699
https://doi.org/10.1183/09031936.93.03060699
Publikováno v:
Anticancer research. 19(6B)
Megakaryocytes are platelet forming cells and are characterized by polyploidization, a phenomenon by which nuclear division occurs without corresponding cytoplasmic separation. Among the markers allowing to identify megakaryocytes, glycoprotein (GP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::971a42b5f1e0d4d979c69628b65ec266
https://pubmed.ncbi.nlm.nih.gov/10697532
https://pubmed.ncbi.nlm.nih.gov/10697532
Publikováno v:
Anticancer research. 19(4B)
Megakaryocyte polyploidization responds to platelet demand and results from the lack of cytoplasmic separation while the nucleus keeps dividing. In order to investigate the role of actin in the megakaryocyte polyploidization, phorbol myristate acetat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::55bf61ebb8f9982d668ca7b6d38ec5c0
https://pubmed.ncbi.nlm.nih.gov/10652621
https://pubmed.ncbi.nlm.nih.gov/10652621
Publikováno v:
Anticancer research. 19(4B)
In order to investigate the protein synthesis in megakaryocyte polyploidization, phorbol myristate acetate (PMA, 5 x 10(-9) M), a differentiation marker known to induce megakaryocyte polyploidization, was added to human megakaryocytic cell lines (DAM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::674be079ad7fd58469f7ae6ee4703371
https://pubmed.ncbi.nlm.nih.gov/10652616
https://pubmed.ncbi.nlm.nih.gov/10652616
Publikováno v:
Anticancer research. 19(5B)
Megakaryocytes undergo a peculiar and irreversible program by which they become polyploid through repeated cycles of DNA synthesis without concomitant cell division. In order to study the possible concomitant role of protein kinase C and actin in meg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::54c8846237d3d00cdec6c84d75ae8c54
https://pubmed.ncbi.nlm.nih.gov/10628374
https://pubmed.ncbi.nlm.nih.gov/10628374
Publikováno v:
Haematologia. 29(3)
A flow cytofluorometric measurement of megakaryocyte ploidy has been adapted from Tomer's method. Briefly, bone marrow is aspirated through a medium containing theophyllin, prostaglandin-E1 and other antiaggregant agents. Megakaryocytes-enriched buff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fdab7a0a8b089e3a4a5a30c979855c9e
https://pubmed.ncbi.nlm.nih.gov/10069447
https://pubmed.ncbi.nlm.nih.gov/10069447
Publikováno v:
Anticancer research. 18(5A)
Platelet production is a regulated phenomenon. Indeed, megakaryocyte volume is inversely correlated to the platelet count not only in normal individuals and immune thrombocytopenic purpura patients, but also, and surprisingly, in chronic myeloid leuk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7d63a5fff1eed9767a0b14c79ef1f180
https://pubmed.ncbi.nlm.nih.gov/9858907
https://pubmed.ncbi.nlm.nih.gov/9858907