Zobrazeno 1 - 10
of 81
pro vyhledávání: '"M, Suffness"'
Autor:
G. Johnson, G. G. Cragg, M. Wolpert, M. Suffness, M. M. Grever, J. A. R. Mead, F. F. Grifo, J. J. Venditti, S. S. Schepartz
Publikováno v:
International Journal of Pharmacognosy. 33:5-16
The high interest in natural products as sources of pharmaceutical products led to the creation of the National Cooperative Natural Products Drug Discovery Group (NCNPDDG) Program by the National Cancer Institute with the goal of bringing together sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ca73ce12fb358a1da4e2a11a42a735e
https://doi.org/10.3109/13880209509067083
https://doi.org/10.3109/13880209509067083
Autor:
S. A. Schepartz, John H. Cardellina, Michael R. Grever, M. Suffness, Michael R. Boyd, C. M. Cragg, Kenneth M. Snader
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02f30430972b31450cf967a3f7bfeae5
https://doi.org/10.1002/chin.199420317
https://doi.org/10.1002/chin.199420317
Publikováno v:
Phytochemical Analysis. 2:107-111
Simple bench-top bioassays involving brine shrimp lethality, Lemna frond proliferation, and the inhibition of crown gall tumours on potato discs, as well as the human tumour cell lines A-549 lung carcinoma, MCF-7 breast carcinoma and HT-29 colon aden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7397ce7a9d7f3e977ed921144a55de5d
https://doi.org/10.1002/pca.2800020303
https://doi.org/10.1002/pca.2800020303
Autor:
M, Suffness
Publikováno v:
In vivo (Athens, Greece). 8(5)
Taxol is well recognized as an antitumor agent and a biochemical tool for studies of microtubules. A proposal is made that taxol is a surrogate for a key endogenous regulator of microtubules, which has the particular function of stabilizing the mitot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e082bfb834f89338d254661023d888d1
https://pubmed.ncbi.nlm.nih.gov/7727737
https://pubmed.ncbi.nlm.nih.gov/7727737
Publikováno v:
Cancer research. 54(3)
Aphidicolin, an inhibitor of DNA polymerases alpha and delta, is cytotoxic in vitro against tumor cells. The poor solubility of aphidicolin has led to the development of aphidicolin glycinate (AG; NSC 303812), a water soluble ester currently in early
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ccba997c2ea84246f1b2701ac6628420
https://pubmed.ncbi.nlm.nih.gov/8306334
https://pubmed.ncbi.nlm.nih.gov/8306334
Autor:
S G, Arbuck, M C, Christian, J S, Fisherman, L A, Cazenave, G, Sarosy, M, Suffness, J, Adams, R, Canetta, K E, Cole, M A, Friedman
Publikováno v:
Journal of the National Cancer Institute. Monographs. (15)
Taxol is the first of a novel class of anticancer drugs, the taxanes. Taxol's unique effects include its ability to polymerize tubulin into stable microtubules in the absence of cofactors and to induce the formation of stable microtubule bundles. Dur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cc36a1ca9ef2918023e7cfcf97271a72
https://pubmed.ncbi.nlm.nih.gov/7912517
https://pubmed.ncbi.nlm.nih.gov/7912517
Autor:
S G, Arbuck, H, Strauss, E, Rowinsky, M, Christian, M, Suffness, J, Adams, M, Oakes, W, McGuire, E, Reed, H, Gibbs
Publikováno v:
Journal of the National Cancer Institute. Monographs. (15)
Cardiac toxicity was first noted in patients receiving Taxol during continuous cardiac monitoring, which was performed because of the high incidence of serious hypersensitivity reactions noted early in phase I trials. After cardiac events were docume
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f1c0b37982bb8420c252200d114d9ca1
https://pubmed.ncbi.nlm.nih.gov/7912518
https://pubmed.ncbi.nlm.nih.gov/7912518
Publikováno v:
Antimicrobial agents and chemotherapy. 22(2)
Bruceantin, purified from an Ethiopian plant used to treat dysentery, killed Entamoeba histolytica in vitro (IC50 [the concentration of drug which decreased the number of colonies to half that of controls] = 0.018 microgram/ml). Six related quassinoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91103dc0d6349d3784a5c34b915f5400
https://pubmed.ncbi.nlm.nih.gov/6100431
https://pubmed.ncbi.nlm.nih.gov/6100431
Publikováno v:
Cancer treatment reports. 71(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e517d4aae0acacdcdb9534acb4a7b0eb
https://pubmed.ncbi.nlm.nih.gov/3552221
https://pubmed.ncbi.nlm.nih.gov/3552221
Autor:
J. Douros, M. Suffness
Publikováno v:
New Drugs in Cancer Chemotherapy ISBN: 9783642815676
Twenty-six new agents of natural products origin which are under preclinical development as potential antitumor agents at the National Cancer Institute are discussed with reference to their sources, structures, antitumor activity, current status, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1b38f5807be9ee090f00698aa15d2e4
https://doi.org/10.1007/978-3-642-81565-2_14
https://doi.org/10.1007/978-3-642-81565-2_14
