Výsledky vyhledávání

Preferential and persistent activation of the STAT1 pathway in rheumatoid synovial fluid cells

Autor: A, Yokota, M, Narazaki, Y, Shima, N, Murata, T, Tanaka, M, Suemura, K, Yoshizaki, H, Fujiwara, I, Tsuyuguchi, T, Kishimoto

Publikováno v: The Journal of rheumatology. 28(9)

Inflammatory cytokines such as interleukin 1 (IL-1), IL-6, and tumor necrosis factor-alpha are produced in great quantities in inflamed rheumatoid joints. However, little is known about the pathogenic significance of each cytokine in the proliferativ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2e0c3c2916cd1c7dfdb0c5b529105b6e
https://pubmed.ncbi.nlm.nih.gov/11550959

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Reduction of atherosclerosis despite hypercholesterolemia in lyn-deficient mice fed a high-fat diet

Autor: S, Miki, K, Horikawa, H, Nishizumi, M, Suemura, B, Sato, M, Yamamoto, K, Takatsu, T, Yamamoto, Y, Miki

Publikováno v: Genes to cells : devoted to molecularcellular mechanisms. 6(1)

Oxidation and other modifications of serum low-density lipoprotein (LDL) are associated with the development of atherosclerosis, and a scavenger receptor and CD40 signalling are also known to play important roles in the process. We previously showed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::53567f9d9b1d4ee4f690e9f527b5983a
https://pubmed.ncbi.nlm.nih.gov/11168595

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Enhanced expression and DNA binding activity of two CCAAT/enhancer-binding protein isoforms, C/EBPbeta and C/EBPdelta, in rheumatoid synovium

Autor: K, Nishioka, S, Ohshima, M, Umeshita-Sasai, N, Yamaguchi, T, Mima, S, Nomura, N, Murata, M, Shimizu, T, Miyake, K, Yoshizaki, M, Suemura, T, Kishimoto, Y, Saeki

Publikováno v: Arthritis and rheumatism. 43(7)

To investigate the activation and expression of CCAAT/enhancer-binding proteins (C/EBP), especially C/EBPbeta and -delta, in rheumatoid synovium, and their pathogenic implications in rheumatoid arthritis (RA).The activation of C/EBPbeta and -delta wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fe56d8db4607d2fffdbe1e4228f8bce4
https://pubmed.ncbi.nlm.nih.gov/10902764

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Long-term follow-up of the changes in circulating cytokines, soluble cytokine receptors, and white blood cell subset counts in patients with rheumatoid arthritis (RA) after monoclonal anti-TNF alpha antibody therapy

Autor: S, Ohshima, Y, Saeki, T, Mima, M, Sasai, K, Nishioka, H, Ishida, M, Shimizu, M, Suemura, R, McCloskey, T, Kishimoto

Publikováno v: Journal of clinical immunology. 19(5)

To investigate the mechanism of the long-lasting efficacy of chimeric monoclonal anti-TNFalpha antibody (cA2) therapy for rheumatoid arthritis (RA), eight patients with refractory RA were treated with a single infusion of cA2 and the changes in circu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::03bb24d3e51f88ad8c0c9492d6ac775e
https://pubmed.ncbi.nlm.nih.gov/10535607

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The absence of IgE antibody-mediated augmentation of immune responses in CD23-deficient mice

Autor: H Fujiwara, H Kikutani, S Suematsu, T Naka, K Yoshida, T Tanaka, M Suemura, N Matsumoto, S Kojima

The CD23 antigen, a low-affinity receptor for IgE (Fc epsilon RII), is a type II membrane-bound glycoprotein expressed on various cells, particularly mature B cells. A number of functions have been ascribed to CD23, including specific regulation of I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f646e73e4188fdc8e249527635eb365f
https://europepmc.org/articles/PMC44292/

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[IgE-mediated allergy and Fc epsilon receptor II]

Autor: M, Suemura

Publikováno v: Nihon Kyobu Shikkan Gakkai zasshi. 30(8)

Two types of IgE receptors, Fc epsilon receptor I (Fc epsilon RI) and Fc epsilon receptor II (Fc epsilon RII), are known to be involved in IgE-mediated allergy. Fc epsilon RI is expressed on mast cells and basophils, and cross-linkage of Fc epsilon R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::83ed02ddadf6b5123a8ae06eccc06728
https://pubmed.ncbi.nlm.nih.gov/1434215

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[Immunologically mediated bronchial asthma]

Autor: M, Aitani, M, Suemura, T, Kishimoto

Publikováno v: Kokyu to junkan. Respirationcirculation. 40(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b9a75bc9cb722d54b292fe7d49c88cb7
https://pubmed.ncbi.nlm.nih.gov/1533050

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Significance of soluble Fc epsilon receptor II (sFc epsilon RII/CD23) in serum and possible application of sFc epsilon RII for the prevention of allergic reactions

Autor: M, Suemura, H, Kikutani, K, Sugiyama, N, Uchibayashi, M, Aitani, T, Kuritani, E L, Barsumian, A, Yamatodani, T, Kishimoto

Publikováno v: Allergy proceedings : the official journal of regional and state allergy societies. 12(3)

The significance of sFc epsilon RII in IgE-mediated allergic disease was examined. sFc epsilon RII in serum was found to decrease following clinical improvement, suggesting sFc epsilon RII in serum may be an indicator of allergic diseases. Significan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6f8c26cc11100d5db962f1ae95921c5d
https://pubmed.ncbi.nlm.nih.gov/1716601

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