Adjuvant nivolumab, capecitabine or the combination in patients with residual triple-negative breast cancer: the OXEL randomized phase II study

Autor: Filipa Lynce, Candace Mainor, Renee N. Donahue, Xue Geng, Greg Jones, Ilana Schlam, Hongkun Wang, Nicole J. Toney, Caroline Jochems, Jeffrey Schlom, Jay Zeck, Christopher Gallagher, Rita Nanda, Deena Graham, Erica M. Stringer-Reasor, Neelima Denduluri, Julie Collins, Ami Chitalia, Shruti Tiwari, Raquel Nunes, Rebecca Kaltman, Katia Khoury, Margaret Gatti-Mays, Paolo Tarantino, Sara M. Tolaney, Sandra M. Swain, Paula Pohlmann, Heather A. Parsons, Claudine Isaacs

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract Chemotherapy and immune checkpoint inhibitors have a role in the post-neoadjuvant setting in patients with triple-negative breast cancer (TNBC). However, the effects of nivolumab, a checkpoint inhibitor, capecitabine, or the combination in c

Externí odkaz: https://doaj.org/article/6ac20f46999d4c22ad7ae1d4db6d5b32

Precision measurement of the specific activity of $$^{39}$$ 39 Ar in atmospheric argon with the DEAP-3600 detector

Autor: P. Adhikari, R. Ajaj, M. Alpízar-Venegas, P.-A. Amaudruz, J. Anstey, G. R. Araujo, D. J. Auty, M. Baldwin, M. Batygov, B. Beltran, H. Benmansour, C. E. Bina, J. Bonatt, W. Bonivento, M. G. Boulay, B. Broerman, J. F. Bueno, P. M. Burghardt, A. Butcher, M. Cadeddu, B. Cai, M. Cárdenas-Montes, S. Cavuoti, M. Chen, Y. Chen, S. Choudhary, B. T. Cleveland, J. M. Corning, R. Crampton, D. Cranshaw, S. Daugherty, P. DelGobbo, K. Dering, P. Di Stefano, J. DiGioseffo, G. Dolganov, L. Doria, F. A. Duncan, M. Dunford, E. Ellingwood, A. Erlandson, S. S. Farahani, N. Fatemighomi, G. Fiorillo, S. Florian, A. Flower, R. J. Ford, R. Gagnon, D. Gallacher, P. García Abia, S. Garg, P. Giampa, A. Giménez-Alcázar, D. Goeldi, V. V. Golovko, P. Gorel, K. Graham, D. R. Grant, A. Grobov, A. L. Hallin, M. Hamstra, P. J. Harvey, S. Haskins, C. Hearns, J. Hu, J. Hucker, T. Hugues, A. Ilyasov, B. Jigmeddorj, C. J. Jillings, A. Joy, O. Kamaev, G. Kaur, A. Kemp, M. Kuźniak, F. La Zia, M. Lai, S. Langrock, B. Lehnert, A. Leonhardt, J. LePage-Bourbonnais, N. Levashko, J. Lidgard, T. Lindner, M. Lissia, J. Lock, L. Luzzi, I. Machulin, P. Majewski, A. Maru, J. Mason, A. B. McDonald, T. McElroy, T. McGinn, J. B. McLaughlin, R. Mehdiyev, C. Mielnichuk, L. Mirasola, J. Monroe, P. Nadeau, C. Nantais, C. Ng, A. J. Noble, E. O’Dwyer, G. Oliviéro, C. Ouellet, S. Pal, D. Papi, P. Pasuthip, S. J. M. Peeters, M. Perry, V. Pesudo, E. Picciau, M.-C. Piro, T. R. Pollmann, F. Rad, E. T. Rand, C. Rethmeier, F. Retière, I. Rodríguez García, L. Roszkowski, J. B. Ruhland, R. Santorelli, F. G. Schuckman II, N. Seeburn, S. Seth, V. Shalamova, K. Singhrao, P. Skensved, N. J. T. Smith, B. Smith, K. Sobotkiewich, T. Sonley, J. Sosiak, J. Soukup, R. Stainforth, C. Stone, V. Strickland, M. Stringer, B. Sur, J. Tang, E. Vázquez-Jáuregui, L. Veloce, S. Viel, B. Vyas, M. Walczak, J. Walding, M. Ward, S. Westerdale, J. Willis, A. Zuñiga-Reyes, DEAP Collaboration

Publikováno v: European Physical Journal C: Particles and Fields, Vol 83, Iss 7, Pp 1-10 (2023)

Abstract The specific activity of the $$\beta $$ β decay of $$^{39}$$ 39 Ar in atmospheric argon is measured using the DEAP-3600 detector. DEAP-3600, located 2 km underground at SNOLAB, uses a total of (3269 ± 24) kg of liquid argon distilled from

Externí odkaz: https://doaj.org/article/bbbf6102079d43389ed22d1b2303d782

Measurement of isotopic separation of argon with the prototype of the cryogenic distillation plant Aria for dark matter searches

Autor: E. Aaron, P. Agnes, I. Ahmad, S. Albergo, I. F. M. Albuquerque, T. Alexander, A. K. Alton, P. Amaudruz, M. Atzori Corona, M. Ave, I. Ch. Avetisov, O. Azzolini, H. O. Back, Z. Balmforth, A. Barrado, P. Barrillon, A. Basco, G. Batignani, V. Bocci, W. M. Bonivento, B. Bottino, M. G. Boulay, J. Busto, M. Cadeddu, A. Caminata, N. Canci, A. Capra, S. Caprioli, M. Caravati, N. Cargioli, M. Carlini, P. Castello, P. Cavalcante, S. Cavuoti, S. Cebrian, J. M. Cela Ruiz, S. Chashin, A. Chepurnov, E. Chyhyrynets, L. Cifarelli, D. Cintas, M. Citterio, B. Cleveland, V. Cocco, E. Conde Vilda, L. Consiglio, S. Copello, G. Covone, M. Czubak, M. D’Aniello, S. D’Auria, M. D. Da Rocha Rolo, S. Davini, S. De Cecco, G. De Guido, D. De Gruttola, S. De Pasquale, G. De Rosa, G. Dellacasa, A. V. Derbin, A. Devoto, F. Di Capua, L. Di Noto, P. Di Stefano, G. Dolganov, F. Dordei, E. Ellingwood, T. Erjavec, S. Farenzena, M. Fernandez Diaz, G. Fiorillo, P. Franchini, D. Franco, N. Funicello, F. Gabriele, D. Gahan, C. Galbiati, G. Gallina, G. Gallus, M. Garbini, P. Garcia Abia, A. Gendotti, C. Ghiano, C. Giganti, G. K. Giovanetti, V. Goicoechea Casanueva, A. Gola, G. Grauso, G. Grilli di Cortona, A. Grobov, M. Gromov, M. Guan, M. Guerzoni, M. Gulino, C. Guo, B. R. Hackett, A. L. Hallin, A. Hamer, M. Haranczyk, T. Hessel, S. Hill, S. Horikawa, F. Hubaut, J. Hucker, T. Hugues, An. Ianni, V. Ippolito, C. Jillings, S. Jois, P. Kachru, A. A. Kemp, C. L. Kendziora, M. Kimura, I. Kochanek, K. Kondo, G. Korga, S. Koulosousas, A. Kubankin, M. Kuss, M. Kuźniak, M. La Commara, M. Lai, N. Lami, E. Le Guirriec, E. Leason, A. Leoni, L. Lidey, F. Lippi, M. Lissia, L. Luzzi, O. Lychagina, N. Maccioni, O. Macfadyen, I. N. Machulin, S. Manecki, I. Manthos, L. Mapelli, A. Margotti, S. M. Mari, C. Mariani, J. Maricic, A. Marini, M. Martínez, C. J. Martoff, M. Mascia, A. Masoni, G. Matteucci, K. Mavrokoridis, C. Maxia, A. B. McDonald, A. Messina, R. Milincic, A. Mitra, A. Moharana, S. Moioli, J. Monroe, E. Moretti, M. Morrocchi, T. Mróz, V. N. Muratova, C. Muscas, P. Musico, R. Nania, M. Nessi, K. Nikolopoulos, J. Nowak, K. Olchansky, A. Oleinik, V. Oleynikov, P. Organtini, A. Ortiz de Solórzano, L. Pagani, M. Pallavicini, L. Pandola, E. Pantic, E. Paoloni, G. Paternoster, P. A. Pegoraro, K. Pelczar, L. A. Pellegrini, C. Pellegrino, V. Pesudo, S. Piacentini, L. Pietrofaccia, N. Pino, A. Pocar, D. M. Poehlmann, S. Pordes, P. Pralavorio, D. Price, F. Ragusa, Y. Ramachers, M. Razeti, A. L. Renshaw, M. Rescigno, F. Retiere, L. P. Rignanese, C. Ripoli, A. Rivetti, A. Roberts, C. Roberts, J. Rode, G. Rogers, L. Romero, M. Rossi, A. Rubbia, M. A. Sabia, G. M. Sabiu, P. Salomone, E. Sandford, S. Sanfilippo, D. Santone, R. Santorelli, C. Savarese, E. Scapparone, G. Schillaci, F. Schukman, G. Scioli, M. Simeone, P. Skensved, M. D. Skorokhvatov, O. Smirnov, T. Smirnova, B. Smith, F. Spadoni, M. Spangenberg, R. Stefanizzi, A. Steri, V. Stornelli, S. Stracka, M. Stringer, S. Sulis, A. Sung, Y. Suvorov, A. M. Szelc, R. Tartaglia, A. Taylor, J. Taylor, S. Tedesco, G. Testera, K. Thieme, T. N. Thorpe, A. Tonazzo, A. Tricomi, E. V. Unzhakov, T. Vallivilayil John, M. Van Uffelen, T. Viant, S. Viel, R. B. Vogelaar, J. Vossebeld, M. Wada, M. B. Walczak, H. Wang, Y. Wang, S. Westerdale, L. Williams, I. Wingerter-Seez, R. Wojaczyński, Ma. M. Wojcik, T. Wright, Y. Xie, C. Yang, A. Zabihi, P. Zakhary, A. Zani, A. Zichichi, G. Zuzel, M. P. Zykova, DarkSide-20k Collaboration

Publikováno v: European Physical Journal C: Particles and Fields, Vol 83, Iss 5, Pp 1-13 (2023)

Abstract The Aria cryogenic distillation plant, located in Sardinia, Italy, is a key component of the DarkSide-20k experimental program for WIMP dark matter searches at the INFN Laboratori Nazionali del Gran Sasso, Italy. Aria is designed to purify t

Externí odkaz: https://doaj.org/article/9b1250617cec4d2a9ab7851ef92aaaa7

Xrcc5/KU80 is not required for the survival or activation of prophase-arrested oocytes in primordial follicles

Autor: Natasha D. Ratnayaka-Gamage, Lauren R. Alesi, Nadeen Zerafa, Jessica M. Stringer, Karla J. Hutt

Publikováno v: Frontiers in Endocrinology, Vol 14 (2023)

IntroductionThe non-growing, meiotically-arrested oocytes housed within primordial follicles are exquisitely sensitive to genotoxic insults from endogenous and exogenous sources. Even a single DNA double-strand break (DSB) can trigger oocyte apoptosi

Externí odkaz: https://doaj.org/article/5f5fb79aac544827af9939d421f1dc2e

The simulation of mineral dust in the United Kingdom Earth System Model UKESM1

Autor: S. Woodward, A. A. Sellar, Y. Tang, M. Stringer, A. Yool, E. Robertson, A. Wiltshire

Publikováno v: Atmospheric Chemistry and Physics, Vol 22, Pp 14503-14528 (2022)

Mineral dust plays an important role in Earth system models and is linked to many components, including atmospheric wind speed, precipitation and radiation, surface vegetation cover and soil properties and oceanic biogeochemical systems. In this pape

Externí odkaz: https://doaj.org/article/5912fd239fe24f3f88d32e93b816eb1a